Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body Pathway

Autor: Mahsa Ebrahimi, Lukas Habernig, Filomena Broeskamp, Andreas Aufschnaiter, Jutta Diessl, Isabel Atienza, Steffen Matz, Felix A. Ruiz, Sabrina Büttner

Publikováno v: Cells, Vol 10, Iss 11, p 3161 (2021)

Nutrient limitation results in an activation of autophagy in organisms ranging from yeast, nematodes and flies to mammals. Several evolutionary conserved nutrient-sensing kinases are critical for efficient adaptation of yeast cells to glucose, nitrog

Externí odkaz: https://doaj.org/article/66272d53b3b0473b863a7fdb23b8b284

Polyphosphate Activates von Willebrand Factor Interaction with Glycoprotein Ib in the Absence of Factor VIII In Vitro

Autor: Marcela Montilla, Isabel Atienza-Navarro, Francisco Jose García-Cozar, Carmen Castro, Francisco Javier Rodríguez-Martorell, Felix A. Ruiz

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14118

Polyphosphate (polyP), a phosphate polymer released by activated platelets, may modulate various stages of hemostasis by binding to blood proteins. In this context, we previously reported that polyP binds to the von Willebrand factor (VWF). One of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e014d21c83e617b42ea2f1c65d69f4
https://doi.org/10.3390/ijms232214118

Targeting Protein Kinase C in Glioblastoma Treatment

Autor: Irene Iglesias-Lozano, Felix A. Ruiz, Ricardo Pardillo-Díaz, Noelia Geribaldi-Doldán, José L. Gil-Salú, Ricardo Gómez-Oliva, Livia Carrascal, Pedro Nunez-Abades, Luis M. Valor, Irati Hervás-Corpión, Carmen Castro, Samuel Domínguez-García

Publikováno v: Biomedicines, Vol 9, Iss 381, p 381 (2021)
Biomedicines 2021, 9(4), 381
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Biomedicines

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58253d4d5f7a519ca955bdc58d3f1f8
https://www.mdpi.com/2227-9059/9/4/381

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries

Autor: Felix A. Ruiz, Pedro Nunez-Abades, Carmen Castro, Monica Garcia-Alloza, Antonio J. Macías-Sánchez, Livia Carrascal, Noelia Geribaldi-Doldán, Cristina Verástegui, Samuel Domínguez-García, Ricardo Gómez-Oliva, Rosario Hernández-Galán, Jorge Bolivar

Publikováno v: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Cell Death & Disease
Cell Death and Disease (2020) 11:262
Cell Death and Disease, Vol 11, Iss 4, Pp 1-19 (2020)
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b12008c06e9ad084f1fc9facf301050

Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome

Autor: Henning J. Jessen, Alexandre Hofer, Tanya Singh, Jyoti Singh, Adolfo Saiardi, Nicole Steck, Cristina Azevedo, Felix A. Ruiz

Publikováno v: ACS Chemical Biology. 13:1958-1963

Phenotypes are established by tight regulation on protein functions. This regulation can be mediated allosterically, through protein binding, and covalently, through post-translational modification (PTM). The integration of an ever-increasing number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c597f44240d7c3d069501a3e816823d
https://doi.org/10.1021/acschembio.8b00357