Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Felix Epie"'
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b67169430f8d7544a01fb0b95c703d
https://doi.org/10.1021/acs.jmedchem.5b00961
https://doi.org/10.1021/acs.jmedchem.5b00961
Autor:
Michael W. Wood, Jan Antoinette C. Romero, Yugui Gu, Yanzhi Zhang, Scott Coleman, Chester A. Metcalf, Ian Parr, Ajit Chavan, M. Dominic Ryan, Jason Kwong, Cassandra Abel, Jason B. Cross, Tongchuan Li, Jonathan F. Lawrence, Ole A. Andersen, Ryan Heney, Katherine M. Poutsiaka, Robert K. Y. Cheng, Felix Epie, Ning Yin, Liu Christopher Matthew, Audrey Chan, Cynthia Clark, Prudencio S. Herradura, Azard Mahamoon, Mary Conrad, Kien T. Nguyen, Jennifer Goss, Mark A. Brooks, Edward Clark, Jing Zhang, John M. Barker, Lippa Blaise S
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(8)
The emergence and spread of multidrug-resistant (MDR) Gram negative bacteria presents a serious threat for public health. Novel antimicrobials that could overcome the resistance problems are urgently needed. UDP-3-O-(R-3-hydroxymyristol)-N-acetylgluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08658c3019db1758d8d5c0ab1429532
https://pubmed.ncbi.nlm.nih.gov/28302397
https://pubmed.ncbi.nlm.nih.gov/28302397
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Autor:
Jan Antoinette C. Romero, Michael F. Mesleh, Douglas Bevan, Joseph Shotwell, Ole A. Andersen, Kien T. Nguyen, Bin Wang, Jing Zhang, Katherine M. Poutsiaka, Qingyi Yang, Anu Daniel, Brian Chamberlain, Lippa Blaise S, Nicole M. Carter, Roland E. Dolle, Terence Moy, Chester A. Metcalf, Jason B. Cross, John J. Barker, M. Dominic Ryan, Jared Silverman, Felix Epie
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461bdfd2f15b29c8a0f1afd5fa1ba2d4
https://europepmc.org/articles/PMC4834655/
https://europepmc.org/articles/PMC4834655/
Autor:
Anu Daniel, Chester A. Metcalf, Qingyi Yang, Roland E. Dolle, Jared Silverman, Felix Epie, Anu Arya, Jan Antoinette C. Romero, Kien T. Nguyen, Lippa Blaise S, Terence Moy, Yuchuan Wu, Jason B. Cross, Dominic Ryan, Joseph Shotwell, Douglas Bevan, Brian Chamberlain, Jing Zhang, Nicole M. Carter, Vipul Kumar, Bin Wang, Katherine M. Poutsiaka
Publikováno v:
ACS medicinal chemistry letters. 6(10)
Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52605f8eb4df90c1087a81076555cf21
https://pubmed.ncbi.nlm.nih.gov/26487916
https://pubmed.ncbi.nlm.nih.gov/26487916
Autor:
Jing Zhang, Qingyi Yang, Jason B. Cross, Jan AntoinetteC. Romero, Katherine M. Poutsiaka, Felix Epie, Douglas Bevan, Bin Wang, Yanzhi Zhang, Ajit Chavan, Xin Zhang, Terence Moy, Anu Daniel, Kien Nguyen, Brian Chamberlain, Nicole Carter, Joseph Shotwell, Jared Silverman, Chester A. Metcalf, Dominic Ryan
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8503-8512, 10p