Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Felix, Nikels"'
Autor:
Klaus Wuchner, Linda Yi, Cyrille Chery, Felix Nikels, Friederike Junge, George Crotts, Gianluca Rinaldi, Jason A. Starkey, Karoline Bechtold-Peters, Melissa Shuman, Michael Leiss, Michael Jahn, Patrick Garidel, Rien de Ruiter, Sarah M. Richer, Shawn Cao, Sebastian Peuker, Sylvain Huille, Tingting Wang, Virginie Le Brun
Publikováno v:
Journal of Pharmaceutical Sciences. 111:2955-2967
Polysorbate (PS) 20 and 80 are the main surfactants used to stabilize biopharmaceutical products. Industry practices on various aspects of PS based on a confidential survey and following discussions by 16 globally acting major biotechnology companies
Autor:
Cornelia Hiemenz, Anabel Pacios-Michelena, Constanze Helbig, Valerija Vezočnik, Michael Strebl, Felix Nikels, Andrea Hawe, Patrick Garidel, Tim Menzen
Publikováno v:
Journal of Pharmaceutical Sciences.
Autor:
Srivalli N, Telikepalli, Michael J, Carrier, Dean C, Ripple, Greg, Barnett, Ashwinkumar, Bhirde, Donna, Bolton, George M, Bou-Assaf, Erica, Ferrari, Scott, Leigh, Sophia, Levitskaya-Seaman, Tim, Menzen, Felix, Nikels, Anna, Riley, Miguel, Saggu, Neha, Sahni, Eric, Vernooij, Klaus, Wuchner
Publikováno v:
AAPS PharmSciTech. 24
Visible protein-like particle standards may improve visual inspection and/or appearance testing practices used in the biotechnology industry. They may improve assay performance resulting in better alignment and more standardized training among differ
Autor:
Patrick Garidel, Andrea Hawe, Marina Gühlke, Armin Böhrer, Tim Menzen, Felix Nikels, Johanna Hecht
Publikováno v:
Journal of Pharmaceutical Sciences. 109:505-514
Subvisible particles are a critical quality attribute of pharmaceutical products. The reliability of particle quantitation increases with the number of particles in the analyzed sample volume. However, for analyses of low-volume drug products, such a
Autor:
Klaus Wuchner, Linda Yi, Cyrille Chery, Felix Nikels, Friederike Junge, George Crotts, Gianluca Rinaldi, Jason A. Starkey, Karoline Bechtold-Peters, Melissa Shuman, Michael Leiss, Michael Jahn, Patrick Garidel, Rien de Ruiter, Sarah M Richer, Shawn Cao, Sebastian Peuker, Sylvain Huille, Tingting Wang, Virginie Le Brun
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
Polysorbates (PS) are widely used as a stabilizer in biopharmaceutical products. Industry practices on various aspects of PS are presented in this part 1 survey report based on a confidential survey and following discussions by 16 globally acting maj
Autor:
Nils Krause, Sebastian Kuhn, Patrick Garidel, Andrea Hawe, Erik Frotscher, Tim Menzen, Felix Nikels
Publikováno v:
The AAPS Journal. 23
Flow imaging microscopy (FIM) is widely used to analyze subvisible particles starting from 2 μm in biopharmaceuticals. Recently, an oil-immersion FIM system emerged, the FlowCam Nano, designed to enable the characterization of particle sizes even be
Autor:
Andreas Koeberle, Christina Weinigel, Martin Raasch, Stefan Zahler, Jana Ziereisen, Rolf Müller, Olga Scherer, Angelika M. Vollmar, Katrin Schubert, Alexander S. Mosig, Silke Rummler, Felix Nikels, Carlo Pergola, Simona Pace, Oliver Werz, Stephan Hüttel
Publikováno v:
Scientific Reports
Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or reprogramming of M2 may represent an innovative anti-cancer strategy. The actin cyt
Autor:
Oliver Werz, Antonio Macchiarulo, Felix Nikels, Abdurrahman Olğaç, Burcu Çalışkan, Andrea Carotti, Serkan Levent, Erden Banoglu, Jana Gerstmeier, Ulrike Garscha
Publikováno v:
European journal of medicinal chemistry. 122
Pharmacological intervention with 5-lipoxygenase (5-LO) pathway leading to suppression of leukotriene (LT) biosynthesis is a clinically validated strategy for treatment of respiratory and cardiovascular diseases such as asthma and atherosclerosis. He
Publikováno v:
Pharmacological research. 94
5-Lipoxygenase (5-LO), the key enzyme in the biosynthesis of pro-inflammatory leukotrienes (LTs) from arachidonic acid, is regulated by androgens in human neutrophils and monocytes accounting for sex differences in LT formation. Here we show that pro