Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Felix, Mor"'
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4026 (2008)
The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60
Externí odkaz:
https://doaj.org/article/ed4ba018a2eb4db2b02ee47e0e99af8e
Autor:
Ilan Volovitz, Ofir Goldberger, Zvi Ram, Meir Azulay, Arthur Machlenkin, Shimon Slavin, Irun R. Cohen, Yotvat Marmor, Lea Eisenbach, Felix Mor
Publikováno v:
The Journal of Immunology. 187:5452-5462
Gliomas that grow uninhibited in the brain almost never metastasize outside the CNS. The rare occurrences of extracranial metastasis are usually associated with a suppressed immune system. This observation raises the possibility that some gliomas mig
Publikováno v:
Journal of Neuroimmunology. 208:19-29
Accumulating evidence suggests that autoimmunity against neuronal proteins is important for MS pathogenesis. We have characterized T- and B-cell responses associated with experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with reco
Autor:
Alon Monsonego, Felix Mor
Publikováno v:
Expert Review of Neurotherapeutics. 6:653-659
Alzheimer's disease (AD) is a common and devastating neurodegenerative disease. The incidence of AD is increasing in Western societies. The current treatment of AD is mostly symptomatic and ineffective in stopping or reversing the cognitive impairmen
Autor:
Felix Mor, Irun R. Cohen
Publikováno v:
Journal of Neuroimmunology. 174:3-11
Recent work has shown neuro-protective effects of immunization with self-CNS antigens in animal models of Alzheimer's disease, prion diseases and CNS trauma. The major concern with such an approach is the inadvertent induction of autoimmune disease.
Publikováno v:
Drug Discovery Today: Disease Models. 3:11-14
Behcet's disease (BD) is a chronic systemic inflammatory disease of unknown etiology. Its prevalence has a unique geographic distribution from the Far East to the Mediterranean basin. In addition, the majority of patients carry the class I HLA-B51 ge
Publikováno v:
The Journal of Nutrition. 134:1964-1969
Probiotic bacteria have beneficial effects in infectious and inflammatory diseases, principally in bowel disorders. In the case of chronic progressive autoimmune arthritides, a major goal of treatment is to reduce inflammation. We hypothesized that p
Publikováno v:
The Journal of Immunology. 172:4618-4623
Vascular endothelial growth factor (VEGF) and its receptors are critical in angiogenesis. The main player in the secretion and response to VEGF is the endothelial cell. We initiated this study to test whether T cells can secrete VEGF and are able to
Publikováno v:
The Journal of Immunology. 171:3533-3541
Adjuvant arthritis (AA) is induced by immunizing Lewis rats with Mycobacterium tuberculosis suspended in adjuvant. The mycobacterial 65-kDa heat shock protein (HSP65) contains at least one epitope associated with the pathogenesis of AA: T cell clones
Publikováno v:
The Journal of Immunology. 169:3422-3428
Adjuvant arthritis (AA) is an autoimmune disease inducible in rats involving T cell reactivity to the mycobacterial 65-kDa heat shock protein (HSP65). HSP65-specific T cells cross-reactive with the mammalian 60-kDa heat shock protein (HSP60) are thou