In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study

Autor: Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A. Hans Vija, Roger Schibli, Susanne Geistlich, Martin Behe, Emanuel R. Christ, Damian Wild

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Background A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation. Nevertheless, relatively low tumor radiation doses in patients in

Externí odkaz: https://doaj.org/article/b2acaa6880e14783bd5cb5fd43fcbc99

Accuracy comparison of various quantitative [99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses

Autor: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild, Martin Kretzschmar

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Background There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different 99mTc-dicarboxypropandiphosphate ([99mTc]Tc-DPD) SPECT/CT quantification tools for the d

Externí odkaz: https://doaj.org/article/e8a9d11e3bed42e0b36cd416443018e9

Estimation of differential renal function on routine abdominal imaging employing compressed-sensed contrast-enhanced MR: a feasibility study referenced against dynamic renal scintigraphy in patients with deteriorating renal retention parameters

Autor: Victor Schulze-Zachau, David J. Winkel, Felix Kaul, Theo Demerath, Silke Potthast, Tobias J. Heye, Daniel T. Boll

Publikováno v: Abdominal Radiology. 48:1329-1339

Purpose To assess whether high temporal/spatial resolution GRASP MRI acquired during routine clinical imaging can identify several degrees of renal function impairment referenced against renal dynamic scintigraphy. Methods This retrospective study co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cdd0c6281ef147e53ae50a6ffc1d456
https://doi.org/10.1007/s00261-023-03823-2

Cholecystokinin 2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma: Results of the Lumed Phase 0a Study

Autor: A. Hans Vija, Tilman T. Rau, Michal Cachovan, Emanuel Christ, Anne Schumann, Felix Kaul, Christof Rottenburger, Martin Béhé, Susanne Geistlich, Damian Wild, Guillaume Nicolas, Katharina Glatz, Lisa McDougall, Roger Schibli

Publikováno v: Rottenburger, Christof; Nicolas, Guillaume P; McDougall, Lisa; Kaul, Felix; Cachovan, Michal; Vija, A Hans; Schibli, Roger; Geistlich, Susanne; Schumann, Anne; Rau, Tilman; Glatz, Kathrin; Behe, Martin; Christ, Emanuel R; Wild, Damian (2020). Cholecystokinin-2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma-Results of the Lumed Phase 0a Study. Journal of nuclear medicine, 61(4), pp. 520-526. Society of Nuclear Medicine 10.2967/jnumed.119.233031

Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge. For more than 2 decades it is known that cholecystokinine-2 receptor (CCK2R) is a promising target for the treatment of MTC with radiolabeled minigastrin anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa4f387e84aedbeccba023a05e3a1bc
https://doi.org/10.2967/jnumed.119.233031

Sensitivity Comparison of 68Ga-OPS202 and 68Ga-DOTATOC PET/CT in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Phase II Imaging Study

Autor: Nils Schreiter, Tobias E. Erlanger, Felix Kaul, Damian Wild, Jens Kaufmann, John Uiters, Guillaume Nicolas, Richard Cathomas, Hakim Bouterfa, Melpomeni Fani, Emanuel Christ

Publikováno v: Journal of Nuclear Medicine. 59:915-921

Radiolabeled somatostatin (sst) receptor agonists are integral to the diagnosis of gastroenteropancreatic neuroendocrine tumors (NETs), but detection rates, especially of liver metastases, remain limited even with PET/CT. 68Ga-OPS202 (68Ga-NODAGA-JR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de338f2310c1e4d691bf02746803919
https://doi.org/10.2967/jnumed.117.199760