Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Felix, Elortza"'
Autor:
Unai Mendibil, Yaiza Lópiz-Morales, Blanca Arnaiz, Raquel Ruiz-Hernández, Pablo Martín, Desiré Di-Silvio, Nerea Garcia-Urquia, Felix Elortza, Mikel Azkargorta, Beatriz Olalde, Ander Abarrategi
Publikováno v:
Materials Today Bio, Vol 28, Iss , Pp 101228- (2024)
Full osteochondral regeneration remains a major clinical challenge. Among other experimental cartilage regenerative approaches, decellularized cartilage (DCC) is considered a promising material for generating potentially implantable scaffolds useful
Externí odkaz:
https://doaj.org/article/d97f0a6ff0db4a4c88db672bc78ccf65
Autor:
Orhi Barroso-Gomila, Laura Merino-Cacho, Veronica Muratore, Coralia Perez, Vincenzo Taibi, Elena Maspero, Mikel Azkargorta, Ibon Iloro, Fredrik Trulsson, Alfred C. O. Vertegaal, Ugo Mayor, Felix Elortza, Simona Polo, Rosa Barrio, James D. Sutherland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a challenge. We present BioE3, a powerful approach for matching
Externí odkaz:
https://doaj.org/article/4ccb7e7077984547931c1b4504e71284
Autor:
Ainize Peña-Cearra, Deguang Song, Janire Castelo, Ainhoa Palacios, Jose Luis Lavín, Mikel Azkargorta, Felix Elortza, Miguel Fuertes, Miguel Angel Pascual-Itoiz, Diego Barriales, Itziar Martín-Ruiz, Asier Fullaondo, Ana M. Aransay, Hector Rodríguez, Noah W. Palm, Juan Anguita, Leticia Abecia
Publikováno v:
npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional interactions between the intestinal microbiota and host mitochondria may modulate intestinal inf
Externí odkaz:
https://doaj.org/article/3dff9ee3e3a641b592f1a6aa0abdf433
Autor:
Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon, June Ereño-Orbea
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its structure and mechanism of action restrains the development of drug candidates that unle
Externí odkaz:
https://doaj.org/article/5c643b1a264846e48401b617ac2763ae
Autor:
Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa Cardoso Delgado, Felix Elortza, Jesús Jiménez-Barbero, Ruben Nogueiras, Vincent Prevot, Asis Palazon, María L. Martínez-Chantar
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
SARS-CoV-2 pseudovirus infects human hepatocytes leading to metabolic reprogramming towards glycolysis and impaired mitochondrial activity, and metformin can reduce infection under steatotic conditions.
Externí odkaz:
https://doaj.org/article/3f2d0b36718146559a8c005f572704c4
Autor:
Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Several proteomic approaches allow the analysis of covalent protein SUMOylation, but it remains challenging to systematically study the consequences of a substrate being modified. Here, the authors combine proximity biotinylation and protein-fragment
Externí odkaz:
https://doaj.org/article/a373110170724930bd012a7ad3fa350e
Autor:
Nahia Goñi, Itziar Martínez-Soroa, Oliver Ibarrondo, Mikel Azkargorta, Felix Elortza, David J. Galarreta, Arantxa Acera
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeKeratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL)
Externí odkaz:
https://doaj.org/article/8469b6c8c978422a9683266583c7cee1
Autor:
Gaia Iazzolino, Unai Mendibil, Blanca Arnaiz, Ane Ruiz-de-Angulo, Mikel Azkargorta, Kepa B. Uribe, Neda Khatami, Felix Elortza, Beatriz Olalde, Vanessa Gomez-Vallejo, Jordi Llop, Ander Abarrategi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In vitro cell culture studies are common in the cancer research field, and reliable biomimetic 3D models are needed to ensure physiological relevance. In this manuscript, we hypothesized that decellularized xenograft tumors can serve as an optimal 3D
Externí odkaz:
https://doaj.org/article/d572353a4e7449e3978374c927daa78b
Autor:
Pablo Fernández-Tussy, David Fernández-Ramos, Fernando Lopitz-Otsoa, Jorge Simón, Lucía Barbier-Torres, Beatriz Gomez-Santos, Maitane Nuñez-Garcia, Mikel Azkargorta, Virginia Gutiérrez-de Juan, Marina Serrano-Macia, Rubén Rodríguez-Agudo, Paula Iruzubieta, Juan Anguita, Rui E. Castro, Devin Champagne, Mercedes Rincón, Felix Elortza, Anita Arslanow, Marcin Krawczyk, Frank Lammert, Mélanie Kirchmeyer, Iris Behrmann, Javier Crespo, Shelly C. Lu, José M. Mato, Marta Varela-Rey, Patricia Aspichueta, Teresa C. Delgado, María L. Martínez-Chantar
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 40-54 (2019)
Objective: Non-alcoholic fatty liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead to lipid accumulation and pro
Externí odkaz:
https://doaj.org/article/a17e13bf601849f78b91e8ef169b6cb2
Autor:
Ainhoa Palacios, Leticia Sampedro, Iker A. Sevilla, Elena Molina, David Gil, Mikel Azkargorta, Felix Elortza, Joseba M. Garrido, Juan Anguita, Rafael Prados-Rosales
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-9 (2019)
Abstract Background Both bovine tuberculosis (TB) and paratuberculosis (PTB) are serious and widespread bacterial infections affecting many domestic and wild animal species. However, current vaccines do not confer complete protection and cause interf
Externí odkaz:
https://doaj.org/article/3053de6098044d4997d127559949217e