SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

Autor: Tatiana Dandolini Saccon, Felippe Mousovich-Neto, Raissa Guimarães Ludwig, Victor Corasolla Carregari, Ana Beatriz dos Anjos Souza, Amanda Stephane Cruz dos Passos, Matheus Cavalheiro Martini, Priscilla Paschoal Barbosa, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Julia Forato, Mariene Ribeiro Amorim, Rafael Elias Marques, Flavio Protasio Veras, Ester Barreto, Tiago Tomazini Gonçalves, Isadora Marques Paiva, Narayana P. B. Fazolini, Carolina Mie Kawagosi Onodera, Ronaldo Bragança Martins Junior, Paulo Henrique Cavalcanti de Araújo, Sabrina Setembre Batah, Rosa Maria Mendes Viana, Danilo Machado de Melo, Alexandre Todorovic Fabro, Eurico Arruda, Fernando Queiroz Cunha, Thiago Mattar Cunha, Marco Antônio M. Pretti, Bradley Joseph Smith, Henrique Marques-Souza, Thiago L. Knittel, Gabriel Palermo Ruiz, Gerson S. Profeta, Tereza Cristina Minto Fontes-Cal, Mariana Boroni, Marco Aurélio Ramirez Vinolo, Alessandro S. Farias, Pedro Manoel M. Moraes-Vieira, Joyce Maria Annichino Bizzacchi, Tambet Teesalu, Felipe David Mendonça Chaim, Everton Cazzo, Elinton Adami Chaim, José Luiz Proença-Módena, Daniel Martins-de-Souza, Mariana Kiomy Osako, Luiz Osório Leiria, Marcelo A. Mori

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Visceral adiposity is a risk factor for severe COVID-19, and infection of adipose tissue by SARS-CoV-2 has been reported. Here the authors confirm that human adipose tissue is a possible site for SARS-CoV-2 infection, but the degree of adipose tissue

Externí odkaz: https://doaj.org/article/af9905b4afe84326b4de5ee835598f79

Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

Autor: A. Augusto Peluso, Agnete T. Lundgaard, Parizad Babaei, Felippe Mousovich-Neto, Andréa L. Rocha, Mads V. Damgaard, Emilie G. Bak, Thiyagarajan Gnanasekaran, Ole L. Dollerup, Samuel A. J. Trammell, Thomas S. Nielsen, Timo Kern, Caroline B. Abild, Karolina Sulek, Tao Ma, Zach Gerhart-Hines, Matthew P. Gillum, Manimozhiyan Arumugam, Cathrine Ørskov, Douglas McCloskey, Niels Jessen, Markus J. Herrgård, Marcelo A. S. Mori, Jonas T. Treebak

Publikováno v: Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, 7 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4

The gut microbiota impacts systemic levels of multiple metabolites including NAD+ precursors through diverse pathways. Nicotinamide riboside (NR) is an NAD+ precursor capable of regulating mammalian cellular metabolism. Some bacterial families expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aefc60ca72189b7f5dee47ae981b7a
https://doi.org/10.1038/s41514-023-00106-4

Butyrate Restores the Fat/Lean Mass Ratio Balance and Energy Metabolism and Reinforces the Tight Junction-Mediated Intestinal Epithelial Barrier in Prediabetic Mice Independently of its Anti-Inflammatory and Epigenetic Actions

Autor: Valquiria A. Matheus, Ricardo Beltrame Oliveira, Daniela A. Maschio, Susely F. S. Tada, Gabriela M. Soares, Felippe Mousovich-Neto, Raul G. Costa, Marcelo A. Mori, Helena C. L. Barbosa, Carla Beatriz Collares-Buzato

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47db0ab74c4a6524f29777e14dd41e3f
https://doi.org/10.2139/ssrn.4305558

Influence of Stem Cell Therapy on Thyroid Function and Reactive Oxygen Species Production in Diabetic Rats

Autor: Gustavo Monnerat Cahil, Mariana Lopes de Freitas, Diorney Luiz Souza Gran da Silva, Vânia Maria Corrêa da Costa, Vitória Santório de São José, Felippe Mousovich Neto, Denise P. Carvalho, Ricardo Cardoso, Andrea Claudia Freitas Ferreira, Emiliano Medei, Rodrigo S. Fortunato

Publikováno v: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 50(4)

Cell therapy with mesenchymal stem cells (MSC) has been proposed for the treatment of diabetes mellitus (DM). It is known that the prevalence of thyroid disease is higher among diabetic patients than in general population. Therefore, our aim was to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15da88216d6b89ab2073363f5c65728
https://pubmed.ncbi.nlm.nih.gov/29621815

Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder

Autor: Lucas Costa Hosken, Vítor de Castro Gomes, Graham Cocks, Ana Carolina Corrêa-e-Castro, Anna Claudia Domingos da Silveira da Luz, Sandrine Thuret, Danielle Beckman, Litia Carvalho, Felippe Mousovich-Neto, Gilmara de Nazareth Tavares Bastos, Vânia Maria Corrêa da Costa, Deepak Srivastava, Regina Célia Cussa Kubrusly, Mário Cesar do Nascimento Bevilaqua, William de Sant’Anna Machado, Jesus Landeira-Fernandez, Patrícia F. Gardino, Gisele Pereira Dias, Antonio Egidio Nardi, Renata Fleming

Publikováno v: Behavioural brain research. 263

Generalized anxiety disorder (GAD) is highly prevalent and incapacitating. Here we used the Carioca High-Conditioned Freezing (CHF) rats, a previously validated animal model for GAD, to identify biomarkers and structural changes in the hippocampus th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5ff997b505024c3b663e58cd449be6
https://pubmed.ncbi.nlm.nih.gov/24462725