Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Felipe X. Pimentel-Muiños"'
Autor:
Inmaculada Serramito-Gómez, Emilio Boada-Romero, Raquel Villamuera, Álvaro Fernández-Cabrera, José Luis Cedillo, Ángela Martín-Regalado, Simon Carding, Uli Mayer, Penny P. Powell, Thomas Wileman, Irene García-Higuera, Felipe X. Pimentel-Muiños
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokin
Externí odkaz:
https://doaj.org/article/f827951d5bc9452e960cbed014b2d5d6
Autor:
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective prot
Externí odkaz:
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc
Autor:
Emilio Boada-Romero, Inmaculada Serramito-Gómez, María P. Sacristán, David L. Boone, Ramnik J. Xavier, Felipe X. Pimentel-Muiños
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional T
Externí odkaz:
https://doaj.org/article/34956e407de4444e99fd297358803333
Autor:
Inmaculada Serramito-Gómez, Elena Terraza-Silvestre, Álvaro Fernández-Cabrera, Raquel Villamuera, Felipe X. Pimentel-Muiños
Publikováno v:
Autophagy
A coding allele of ATG16L1 that increases the risk of Crohn disease (T300A; rs2241880) impairs the interaction between the C-terminal WD40 domain (WDD) and proteins containing a WDD-binding motif, thus specifically inhibiting the unconventional autop
Autor:
Felipe X. Pimentel-Muiños
Publikováno v:
Autophagy in Health and Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d9de5e31b27ba6eacfc9caf510dd4a
https://doi.org/10.1016/b978-0-12-822003-0.00016-4
https://doi.org/10.1016/b978-0-12-822003-0.00016-4
Autor:
Mahmoud Abdellatif, Nuzhat Ahsan, Amelina Albornoz, Yahyah Aman, Allen Andres, Catherine Arden, Daniel Asa, Belén Bellido, Sihem Boudina, Alfredo Briones-Herrera, Mauricio Budini, Elizabeth Bueno, Olivier Camuzard, Georges F. Carle, Santosh Chauhan, Ramon Corbalan, Alfredo Criollo, Srinivasulu Dasanna, Guido R.Y. De Meyer, Abhinav Diwan, Maria Jose Donate-Lagartos, Robyn Duttenhefner, Tobias Eisenberg, Evandro F. Fang, Johannes Frank, Valeria Garrido-Moreno, Luis Garrido-Olivares, Merilin Georgiou, Saurav Ghimire, Tania Gómez-Sierra, Ruben Gudmundsrud, Andreas Guenther, Pieter-Jan Guns, Congcong He, G. Vignir Helgason, Nina Hermans, Sergio Hernandez-Diaz, Angela Ianniciello, Moydul Islam, Kautilya Kumar Jena, Hiroshi Katsuki, Martina Korfei, Viktor I. Korolchuk, Nicholas T. Ktistakis, Sergio Lavandero, Mark Li, Senka Ljubojević-Holzer, Poornima Mahavadi, Patrick Main, Maria Manifava, Greg R. Markby, Wim Martinet, Elena Martínez-Klimova, Subhash Mehto, Jason C. Mills, Cédric HG. Neutel, Ngoc Uyen Nhi Nguyen, José Pedraza-Chaverri, Daniel Peña-Oyarzún, Valérie Pierrefite-Carle, Felipe X. Pimentel-Muiños, Thomas Pulinilkunnil, Yoana Rabanal-Ruiz, Megan D. Radyk, Christian Rodríguez, Lynn Roth, Beverly A. Rothermel, Kei Sakamoto, Irene Sanchez-Mirasierra, Simon Sedej, Takahiro Seki, Alvaro Sequeida, Liu Shi, Sangita C. Sinha, Logan Slade, Sandra-Fausia Soukup, Lillian B. Spatz, Bieke Steenput, Takayuki Tatsumi, Kateřina Čechová, Marie-Charlotte Trojani, Satoshi Tsukamoto, Silvia Vega-Rubín-de-Celis, Vishaka Vinod, Martin Vyhnalek, Amelia Williams, Samuel Wyatt, Chenglong Xie, Ling Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9b7da36fa6e070b2f6b58871b491c5f
https://doi.org/10.1016/b978-0-12-822003-0.01002-0
https://doi.org/10.1016/b978-0-12-822003-0.01002-0
Autor:
Diego A Rodriguez, Sebastian Zamorano, Fernanda Lisbona, Diego Rojas‐Rivera, Hery Urra, Juan R Cubillos‐Ruiz, Ricardo Armisen, Daniel R Henriquez, Emily H Cheng, Michal Letek, Tomas Vaisar, Thergiory Irrazabal, Christian Gonzalez‐Billault, Anthony Letai, Felipe X Pimentel‐Muiños, Guido Kroemer, Claudio Hetz
Publikováno v:
EMBO J
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α (IRE1α), which functions as an endoribonuclease that splices the mRNA of the transcription f
Autor:
Raquel Villamuera, Alvaro Fernández-Cabrera, Elena Terraza-Silvestre, Rachid Taouil, Felipe X. Pimentel-Muiños, Inmaculada Serramito-Gómez
Publikováno v:
Autophagy
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
ATG16L1 is a critical mediator of macroautophagy/autophagy required for LC3 lipidation and autophagosome formation. However, ATG16L1 has a C-terminal domain including 7 WD40-type repetitions (WD40 domain, WDD) that is unnecessary for the conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec85dbff33b9a758f27ea4d61634a51a
http://hdl.handle.net/10261/262407
http://hdl.handle.net/10261/262407
Autor:
Emilio Boada-Romero, Lars Vereecke, Inmaculada Serramito-Gómez, Geert van Loo, Felipe X. Pimentel-Muiños, Karolina Slowicka
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
instname
Nature Communications
The C-terminal domain of ATG16L1 includes 7 WD40-type repeats (WD40 domain, WDD) and is not required for canonical macroautophagy/autophagy. Instead, the WDD allows ATG16L1 to induce LC3/Atg8 lipidation in single-membrane compartments, although a det
Autor:
Ioanna Petta, Lars Vereecke, Emilio Boada-Romero, Saskia Lippens, Eef Parthoens, Arne Martens, Felipe X. Pimentel-Muiños, Andy Wullaert, Karolina Slowicka, Mozes Sze, Hanna-Kaisa Vikkula, Riet De Rycke, Geert van Loo, Savvas N. Savvides, Inmaculada Serramito-Gómez
Publikováno v:
Autophagy
Digital.CSIC. Repositorio Institucional del CSIC
instname
NATURE COMMUNICATIONS
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
NATURE COMMUNICATIONS
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
© The Author(s) 2019.
Prevention of inflammatory bowel disease (IBD) relies on tight control of inflammatory, cell death and autophagic mechanisms, but how these pathways are integrated at the molecular level is still unclear. Here we show that
Prevention of inflammatory bowel disease (IBD) relies on tight control of inflammatory, cell death and autophagic mechanisms, but how these pathways are integrated at the molecular level is still unclear. Here we show that