Výsledky vyhledávání - "Felipe S. Pessoto"

Akademický článek

Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin.

Autor: Juliana C Ferreira, Marcelo F Marcondes, Marcelo Y Icimoto, Thyago H S Cardoso, Aryane Tofanello, Felipe S Pessoto, Erica G A Miranda, Tatiana Prieto, Otaciro R Nascimento, Vitor Oliveira, Iseli L Nantes

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0136554 (2015)

We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide. The peroxidase mechanism of Cygb is similar to that of myoglobin. Cygb challeng

Externí odkaz: https://doaj.org/article/5154f7fc995648f3a4cd7147f91d4a87

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Cellular feedback to organotelluranes displays modulation of antioxidant proteins gene expression

Autor: César H. Yokomizo, Rodrigo L. O. R. Cunha, Iseli L. Nantes-Cardoso, Felipe S. Pessoto

Organotelluranes RT3 and RT4 are thiol reagents that induce mitochondrial transition pore (MTP) opening in a sensitive and insensitive manner to cyclosporin A. Although RT3 and RT4 promote glutathione depletion, paradoxically, they are also an effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9dfab5d88e9e4128a1296698b38cff0
https://doi.org/10.1101/2021.01.05.425411

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Thiosemicarbazonep-Substituted Acetophenone Derivatives Promote the Loss of MitochondrialΔψ, GSH Depletion, and Death in K562 Cells

Autor: Carlos R. Kaiser, Alan Patrick da Silva, Cleverton S. Fernandes, Felipe S. Pessoto, César H. Yokomizo, Tatiana Prieto, Iseli L. Nantes, Ernani A. Basso

Publikováno v: Oxidative Medicine and Cellular Longevity. 2015:1-15

A series of thiosemicarbazone (TSC)p-substituted acetophenone derivatives were synthesized and chemically characterized. Thep-substituents appended to the phenyl group of the TSC structures were hydrogen, fluor, chlorine, methyl, and nitro, producing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0fb9a25d55f0766c9247e57cd9e9498
https://doi.org/10.1155/2015/394367

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Specific effects of reactive thiol drugs on mitochondrial bioenergetics

Autor: Tiago Rodrigues, Iseli L. Nantes, Rodrigo L. O. R. Cunha, César H. Yokomizo, Antonio C. F. Caires, Débora P. Santana, Felipe S. Pessoto, Carolina G. dos Santos, Priscila A. Faria, Juliana C. Araujo-Chaves

Publikováno v: Journal of Bioenergetics and Biomembranes. 43:11-18

In this minireview, the more recent findings about the effects of peculiar reactive thiol drugs on mitochondria are presented. These include the following compounds: metallo meso-tetrakis porphyrins, palladacycles, telluranes and phenothiazines. Meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18441a613bb73875cb0e3eb38e9ee69
https://doi.org/10.1007/s10863-011-9328-9

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pH-Sensitive Binding of Cytochrome c to the Inner Mitochondrial Membrane. Implications for the Participation of the Protein in Cell Respiration and Apoptosis

Autor: Verónica Tórtora, Vitor Augusto Milicchio, Ivarne L.S. Tersariol, Rafael Radi, Katia Cristina Ugolini Mugnol, Ana Maria Carmona-Ribeiro, Cintia Kawai, Felipe S. Pessoto, Tiago Rodrigues, Laura Castro, Paolo Di Mascio, Iseli L. Nantes

Publikováno v: Biochemistry. 48:8335-8342

Cytochrome c exhibits two positively charged sites: site A containing lysine residues with high pKa values and site L containing ionizable groups with pKaobs values around 7.0. This protein feature implies that cytochrome c can participate in the fus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9c48ac8e9a57eeaa176db2694b725e
https://doi.org/10.1021/bi9006463

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Organotellurane-Promoted Mitochondrial Permeability Transition Concomitant with Membrane Lipid Protection against Oxidation

Autor: Priscila A. Faria, Tiago Rodrigues, Rodrigo L. O. R. Cunha, Iseli L. Nantes, João Valdir Comasseto, Felipe S. Pessoto

Publikováno v: Chemical Research in Toxicology. 20:1453-1461

Organotelluranes exhibit potent antioxidant properties as well as the ability to react with protein thiol groups and, thereby, they are good models to study the mechanism of the mitochondrial permeability transition (MPT). We evaluated the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67791f2ba1c9688ea099c408588be385
https://doi.org/10.1021/tx700092r

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Effects of trichlorotelluro-dypnones on mitochondrial bioenergetics and their relationship to the reactivity with protein thiols

Autor: Rodrigo L. O. R. Cunha, César H. Yokomizo, Iseli L. Nantes, Felipe S. Pessoto, Tatiana Prieto

Publikováno v: Chemical research in toxicology. 28(6)

The effect of four trichlorotelluro-dypnones, named compounds 1, 2, 3, and 4, on the bioenergetics of isolated rat liver mitochondria (RLM) and cells was investigated. In a dose-dependent manner, the studied organotelluranes promoted Ca(2+)-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9284dee00ec389684b7f8b6d03aa6edb
https://pubmed.ncbi.nlm.nih.gov/25915563

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Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin

Autor: Thyago H.S. Cardoso, Juliana C. Ferreira, Marcelo Y. Icimoto, Marcelo F. Marcondes, Vitor Oliveira, Felipe S. Pessoto, Iseli L. Nantes, Tatiana Prieto, Aryane Tofanello, Otaciro R. Nascimento, Érica G. A. Miranda

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0136554 (2015)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b98969f3fb1923c8c2df39fa429bf0e
https://pubmed.ncbi.nlm.nih.gov/26312997

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Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells

Autor: Felipe S, Pessoto, Cesar H, Yokomizo, Tatiana, Prieto, Cleverton S, Fernandes, Alan P, Silva, Carlos R, Kaiser, Ernani A, Basso, Iseli L, Nantes

Publikováno v: Oxidative Medicine and Cellular Longevity

A series of thiosemicarbazone (TSC) p-substituted acetophenone derivatives were synthesized and chemically characterized. The p-substituents appended to the phenyl group of the TSC structures were hydrogen, fluor, chlorine, methyl, and nitro, produci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b84bc940888733d3bf6adb054b9d5cdc
https://pubmed.ncbi.nlm.nih.gov/26075034

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Effects of transmembrane potential and pH gradient on the cytochrome c-promoted fusion of mitochondrial mimetic membranes

Autor: Iseli L. Nantes, Cintia Kawai, Ana Maria Carmona-Ribeiro, Felipe S. Pessoto, Catharine V. Graves

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The present study investigated the effects of ΔΨ and ΔpH (pH gradient) on the interaction of cytochrome c with a mitochondrial mimetic membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL) leading to ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb05edd0328bf1b82ff15594934809f

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