Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Felipe NÖR"'
Autor:
Felipe Nör, Fernanda Visioli
Publikováno v:
Frontiers in Oral Health, Vol 4 (2023)
Externí odkaz:
https://doaj.org/article/0b2f9aa05b624a51862dc92f9efa6000
Publikováno v:
Frontiers in Oral Health, Vol 3 (2023)
Cancer stem cells (CSC) are a subpopulation of cancer cells that exhibit properties of self-renewal and differentiation and have been implicated in metastasis and treatment failures. There is mounting evidence that carcinogen-initiated mucosal epithe
Externí odkaz:
https://doaj.org/article/65decfe7b32d47ed9a276e5c27b421d6
Autor:
Jacques E. Nör, David A. Tice, Robert E. Hollingsworth, Elaine M. Hurt, Max S. Wicha, Pablo A. Vargas, Vivian P. Wagner, Felipe Nör, Zhaocheng Zhang, Kristy A. Warner, Alexander T. Pearson, Kelsey A. Finkel, Samuel A. Kerk
Purpose: Locoregional recurrence is a frequent treatment outcome for patients with advanced head and neck squamous cell carcinoma (HNSCC). Emerging evidence suggests that tumor recurrence is mediated by a small subpopulation of uniquely tumorigenic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f2910e9f758a2907cf15f873a48a3a
https://doi.org/10.1158/1078-0432.c.6526424.v1
https://doi.org/10.1158/1078-0432.c.6526424.v1
Autor:
Jacques E. Nör, Shaomeng Wang, Manoel Sant'Ana Filho, Joseph I. Helman, Samuel A. Kerk, Alexander T. Pearson, Gerson A. Acasigua, Zhaocheng Zhang, Kristy A. Warner, Felipe Nör
Purpose: Conventional chemotherapy has modest efficacy in advanced adenoid cystic carcinomas (ACC). Tumor recurrence is a major challenge in the management of ACC patients. Here, we evaluated the antitumor effect of a novel small-molecule inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afa120168f9575ec8677d34b36aecea
https://doi.org/10.1158/1078-0432.c.6526476.v1
https://doi.org/10.1158/1078-0432.c.6526476.v1
Autor:
Jacques E. Nör, Shaomeng Wang, Manoel Sant'Ana Filho, Joseph I. Helman, Samuel A. Kerk, Alexander T. Pearson, Gerson A. Acasigua, Zhaocheng Zhang, Kristy A. Warner, Felipe Nör
Supplementary Materials and Methods: Immunohistochemistry, Immunofluorescence, TUNEL staining Supplementary Figure S1. Treatment with MI-773 and/or cisplatin is not toxic to mice. Graph depicting mouse weight during the experimental period. Data were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc3a04c7856ea7ed1bc951c82d6a341
https://doi.org/10.1158/1078-0432.22466907.v1
https://doi.org/10.1158/1078-0432.22466907.v1
Autor:
Jacques E. Nör, Shaomeng Wang, Max S. Wicha, J. Chad Brenner, Joseph I. Helman, Aditi Kulkarni, Samuel Kerk, Zhaocheng Zhang, Felipe Nör, Alexander T. Pearson, Christie Rodriguez-Ramirez, Kristy Warner, April Andrews
Supplementary Methods Supplementary Figure Legends 2 Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0582c393c7f9ba232bf8d12f23f90e1e
https://doi.org/10.1158/1078-0432.22464543.v1
https://doi.org/10.1158/1078-0432.22464543.v1
Autor:
Jacques E. Nör, Shaomeng Wang, Alexander T. Pearson, Rogerio M. Castilho, Christopher A. Moskaluk, Michael J. Wick, Joseph Helman, Douglas B. Chepeha, Matthew E. Spector, Scott A. McLean, Zhaocheng Zhang, Manoela D. Martins, Gerson A. Acasigua, Felipe Nör, Kristy A. Warner
Purpose: There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2–p53 interaction (MI-773) in preclinical models of ACC.Experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950905da0ed9e50c8465852ab595c031
https://doi.org/10.1158/1078-0432.c.6523376
https://doi.org/10.1158/1078-0432.c.6523376
Autor:
Jacques E. Nör, David A. Tice, Robert E. Hollingsworth, Elaine M. Hurt, Max S. Wicha, Pablo A. Vargas, Vivian P. Wagner, Felipe Nör, Zhaocheng Zhang, Kristy A. Warner, Alexander T. Pearson, Kelsey A. Finkel, Samuel A. Kerk
Supplementary Figure 1. PDX models of HNSCC express 5T4. Hematoxilin and eosin staining and immunohistochemistry for 5T4 (brown color) in PDX-SCC-M0, PDX-SCC-M1, and PDX-SCC-M11 models. Supplementary Figure 2. 5T4 expression co-localizes with cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2855d6fc44518a0d794ac9be998dc16d
https://doi.org/10.1158/1078-0432.22466777
https://doi.org/10.1158/1078-0432.22466777
Autor:
Jacques E. Nör, Shaomeng Wang, Max S. Wicha, J. Chad Brenner, Joseph I. Helman, Aditi Kulkarni, Samuel Kerk, Zhaocheng Zhang, Felipe Nör, Alexander T. Pearson, Christie Rodriguez-Ramirez, Kristy Warner, April Andrews
Purpose:Unique cells characterized by multipotency, self-renewal, and high tumorigenic potential have been recently discovered in mucoepidermoid carcinomas. These cells are defined by high aldehyde dehydrogenase activity and high CD44 expression (ALD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9875940ded579763dc1c01fc629bc92d
https://doi.org/10.1158/1078-0432.c.6525741
https://doi.org/10.1158/1078-0432.c.6525741
Autor:
Jacques E. Nör, Shaomeng Wang, Alexander T. Pearson, Rogerio M. Castilho, Christopher A. Moskaluk, Michael J. Wick, Joseph Helman, Douglas B. Chepeha, Matthew E. Spector, Scott A. McLean, Zhaocheng Zhang, Manoela D. Martins, Gerson A. Acasigua, Felipe Nör, Kristy A. Warner
Table S1: (Table depicting patient demographics and tumor characteristics); Table S2: (Table depicting STR profiles of experimental models used here); Figure S1: (Characterization of UM-PDX-HACC-5, a PDX model of adenoid cystic carcinoma); Figure S2:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0397ebfb1a032038b8275d869c9362b5
https://doi.org/10.1158/1078-0432.22456649
https://doi.org/10.1158/1078-0432.22456649