Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Felipe Merino"'
Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The nucleotidyl cyclase toxin exoenzyme Y (ExoY), which is secreted by the human pathogens Pseudomonas aeruginosa and Vibrio vulnificus is activated by actin. Here, the authors present the cryo-EM structures of PaExoY bound to F-actin and VvExoY in c
Externí odkaz:
https://doaj.org/article/e02948cd5c5f46128fc092474e87ab6c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The assembly of branched actin networks depends on the heterodimeric capping protein CP/CapZ. Combining cryoEM, in vitro reconstitution and cell biological assays, the authors show that CP not only prevents actin filament elongation but also selectiv
Externí odkaz:
https://doaj.org/article/0538e02cfebe46a795c981704bc20703
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000925 (2020)
Lifeact is a short actin-binding peptide that is used to visualize filamentous actin (F-actin) structures in live eukaryotic cells using fluorescence microscopy. However, this popular probe has been shown to alter cellular morphology by affecting the
Externí odkaz:
https://doaj.org/article/a7041088ba5546cfa36eb532d1675ded
Autor:
Deivanayagabarathy Vinayagam, Dennis Quentin, Jing Yu-Strzelczyk, Oleg Sitsel, Felipe Merino, Markus Stabrin, Oliver Hofnagel, Maolin Yu, Mark W Ledeboer, Georg Nagel, Goran Malojcic, Stefan Raunser
Publikováno v:
eLife, Vol 9 (2020)
Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising in treating renal diseases. In cells, the channels are reg
Externí odkaz:
https://doaj.org/article/f8aed02aa72f4d6e83161ef260e36d73
Autor:
Johanna Funk, Felipe Merino, Larisa Venkova, Lina Heydenreich, Jan Kierfeld, Pablo Vargas, Stefan Raunser, Matthieu Piel, Peter Bieling
Publikováno v:
eLife, Vol 8 (2019)
The actin cytoskeleton drives many essential biological processes, from cell morphogenesis to motility. Assembly of functional actin networks requires control over the speed at which actin filaments grow. How this can be achieved at the high and vari
Externí odkaz:
https://doaj.org/article/f637458022114ee2ab8bf5b3ebccbb8f
Autor:
Deivanayagabarathy Vinayagam, Thomas Mager, Amir Apelbaum, Arne Bothe, Felipe Merino, Oliver Hofnagel, Christos Gatsogiannis, Stefan Raunser
Publikováno v:
eLife, Vol 7 (2018)
Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated channels (SOC). Their malfunction is related to cardiomyopathies and
Externí odkaz:
https://doaj.org/article/a204259ae8154d9bb57ff379c988ee7c
Autor:
Felipe Merino, Stefan Raunser
Publikováno v:
eLife, Vol 5 (2016)
New insights into the structure of filaments made of crenactin, a homolog of actin found in archaea, shed light on how the cytoskeleton might have evolved.
Externí odkaz:
https://doaj.org/article/773a6cf314d84ee18249166abc7dc8f9
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004287 (2015)
Highly specific transcriptional regulation depends on the cooperative association of transcription factors into enhanceosomes. Usually, their DNA-binding cooperativity originates from either direct interactions or DNA-mediated allostery. Here, we per
Externí odkaz:
https://doaj.org/article/41b2fcddbd36485fb43d36b93af7afcb
Publikováno v:
Biochemical Journal
Proteins are the essential agents of all living systems. Even though they are synthesized as linear chains of amino acids, they must assume specific three-dimensional structures in order to manifest their biological activity. These structures are ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf2058b61394081b862f7503a3ba1c2
https://doi.org/10.1042/bcj20200963
https://doi.org/10.1042/bcj20200963
Publikováno v:
Seminars in Cell & Developmental Biology
Actin filaments (F-actin) are a key component of eukaryotic cells. Whether serving as a scaffold for myosin or using their polymerization to push onto cellular components, their function is always related to force generation. To control and fine-tune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d473f0915b3092a41d23fb320ef2e392
https://doi.org/10.1016/j.semcdb.2019.11.018
https://doi.org/10.1016/j.semcdb.2019.11.018