A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS

Autor: Alejandro Ropolo, Cintia Catrinacio, Felipe Javier Renna, Veronica Boggio, Tamara Orquera, Claudio D. Gonzalez, Maria I. Vaccaro

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which participates in cell response to disease. We previously characterized VMP1 (Vacuole Membrane Protein 1) as an essential autophagy related protein

Externí odkaz: https://doaj.org/article/a83562ffffab45c2b082510a5a31eacc

Initial steps in Mammalian autophagosome biogenesis

Autor: Felipe Javier Renna, Daniel Grasso, Maria I. Vaccaro

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

During the last decade, autophagy has been pointed out as a central process in cellular homeostasis with the consequent implication in most cellular settings and human diseases pathology. At present, there is significant data available about molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02287ff4dcdcb7b6648797aa763ac1bb
https://www.frontiersin.org/article/10.3389/fcell.2018.00146/full

VMP1 mediated zymophagy is triggered by caerulein treatment in differentiated AR42J cells

Autor: Tamara Orquera, Felipe Javier Renna, Maria I. Vaccaro, Daniel Grasso

Publikováno v: Pancreatology. 17:S56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b73fb84b3fa87a0eb1b74d9f02a2528
https://doi.org/10.1016/j.pan.2017.07.183

Critical Role of USP9X in Initial Steps of VMP1-Mediated Autophagy

Autor: Daniel Grasso, Felipe Javier Renna, Maria I. Vaccaro

Publikováno v: Gastroenterology. 152:S1038

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::050d2ea1053d8e33c284680c112a6a93
https://doi.org/10.1016/s0016-5085(17)33507-2

Autophagy mediates resistance to gemcitabine treatment through a novel E2F1-p300-VMP1 pathway

Autor: Maria Ines Molejon, Claudio Gonzalez, Veronica Boggio, Maria I. Vaccaro, Felipe Javier Renna, Cintia Catrinacio, Alejandro Ropolo

Publikováno v: Pancreatology. 14:S21

s / Pancreatology 14 (2014) S1eS129 S21 remodelling and ADM formation was evaluated in vitro using a 3D culture system of pancreatic explants from mice expressing the activating Kras (G12D) mutation. Results: Lack of 5-HT in vivo or inhibition of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ad791300b3a8c2056eaa6184ce48097
https://doi.org/10.1016/j.pan.2014.05.443