Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Felipe Cia"'
Autor:
Hannah Painter, Satria A. Prabowo, Felipe Cia, Lisa Stockdale, Rachel Tanner, Samuel Willcocks, Rajko Reljic, Helen A. Fletcher, Andrea Zelmer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract In the absence of a correlate(s) of protection against human tuberculosis and a validated animal model of the disease, tools to facilitate vaccine development must be identified. We present an optimised ex vivo mycobacterial growth inhibitio
Externí odkaz:
https://doaj.org/article/8e428b49b409439e8ebb3565742e632f
Autor:
Andrea Zelmer, Lisa Stockdale, Satria A. Prabowo, Felipe Cia, Natasha Spink, Matthew Gibb, Ayad Eddaoudi, Helen A. Fletcher
Publikováno v:
F1000Research, Vol 7 (2018)
Background: The only available tuberculosis (TB) vaccine, Bacillus Calmette-Guérin (BCG), has variable efficacy. New vaccines are therefore urgently needed. Why BCG fails is incompletely understood, and the tools used for early assessment of new vac
Externí odkaz:
https://doaj.org/article/d735e674f24544de92997df652835de4
Autor:
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196202 (2018)
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial
Externí odkaz:
https://doaj.org/article/fe6541b36cfb47da8b178eaceaeac091
Autor:
Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005770 (2016)
Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25
Externí odkaz:
https://doaj.org/article/d8ad9bcf1937474182e449b1af1359d0
Publikováno v:
Future Microbiology. 15:241-257
Aim: We sought to characterize the contribution of the O-OTase, PglL, to virulence in two Burkholderia spp. by comparing isogenic mutants in Burkholderia pseudomallei with the related species, Burkholderia thailandensis. Materials & methods: We utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ef68b15999fbe507d36923496ee74f
https://doi.org/10.2217/fmb-2019-0165
https://doi.org/10.2217/fmb-2019-0165
Autor:
Andrea Zelmer, Helen A. Fletcher, Rajko Reljic, Hannah Painter, Sam Willcocks, Lisa Stockdale, Satria A. Prabowo, Felipe Cia, Rachel Tanner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
In the absence of a correlate(s) of protection against human tuberculosis and a validated animal model of the disease, tools to facilitate vaccine development must be identified. We present an optimised ex vivo mycobacterial growth inhibition assay (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1fec5cb0aa6d8ef6baebb2dadacca5
https://doaj.org/article/8e428b49b409439e8ebb3565742e632f
https://doaj.org/article/8e428b49b409439e8ebb3565742e632f
Autor:
Samuel J, Willcocks, Carmen, Denman, Felipe, Cia, Elizabeth, McCarthy, Jon, Cuccui, Brendan W, Wren
Publikováno v:
Future microbiology
Aim We sought to characterize the contribution of the O-OTase, PglL, to virulence in two Burkholderia spp. by comparing isogenic mutants in Burkholderia pseudomallei with the related species, Burkholderia thailandensis. Materials & methods We utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5786fdc88762dab9da551f415d04d525
https://pubmed.ncbi.nlm.nih.gov/32271107
https://pubmed.ncbi.nlm.nih.gov/32271107
Autor:
Priscille Brodin, Christophe Guilhot, Simon Clark, Sung Jae Shin, Olivier Neyrolles, Florence Levillain, Felipe Cia, Wladimir Malaga, Gregory J. Bancroft, Hongmin Kim, Yannick Poquet, Ann Williams, Brigitte Gicquel, Kee Woong Kwon, Faye Lanni
Publikováno v:
Vaccine
Vaccine, Elsevier, 2020, 38 (6), pp.1416-1423. ⟨10.1016/j.vaccine.2019.11.085⟩
Vaccine, Elsevier, 2020, 38 (6), pp.1416-1423. ⟨10.1016/j.vaccine.2019.11.085⟩
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgently needed. One of the challenges for novel TB vaccines is to protect against all Mycobacterium tuberculosis lineages, including the most virulent one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e7ab780b4eb596c571468448cda351
https://hal.archives-ouvertes.fr/hal-03014488
https://hal.archives-ouvertes.fr/hal-03014488
Autor:
Supason Wanichwecharungruang, Chutamath Sittplangkoon, Felipe Cia, Tanapat Palaga, Pritsana Sawutdeechaikul, Gregory J. Bancroft
Publikováno v:
Journal of microbiology and biotechnology. 29(3)
Subunit vaccines are safer and more stable than live vaccines although they have the disadvantage of eliciting poor immune response. To develop a subunit vaccine, an effective delivery system targeting the key elements of the protective immune respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdbafc28e1a3375d9dac5aa64ad495b
https://pubmed.ncbi.nlm.nih.gov/30691253
https://pubmed.ncbi.nlm.nih.gov/30691253
Publikováno v:
International Journal of Antimicrobial Agents
Highlights • Aminocoumarins can be used to treat acute pulmonary melioidosis in a murine model. • Formulation with l-tyrosine or dl-tryptophan enhances the bioactivity of aminocoumarins. • Utility of Galleria mellonella larvae for in vivo drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20353189937853ef7043b425dc424bf
https://doi.org/10.1016/j.ijantimicag.2020.106002
https://doi.org/10.1016/j.ijantimicag.2020.106002