Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Felipe C Geyer"'
Autor:
Lea A. Moukarzel, Lorenzo Ferrando, Arnaud Da Cruz Paula, David N. Brown, Felipe C. Geyer, Fresia Pareja, Salvatore Piscuoglio, Anastasios D. Papanastasiou, Nicola Fusco, Caterina Marchiò, Nadeem R. Abu‐Rustum, Rajmohan Murali, Edi Brogi, Hannah Y. Wen, Larry Norton, Robert A. Soslow, Anne Vincent‐Salomon, Jorge S. Reis‐Filho, Britta Weigelt
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 1024-1039 (2021)
Metaplastic breast carcinoma (MBC) and uterine carcinosarcoma (UCS) are rare aggressive cancers, characterized by an admixture of adenocarcinoma and areas displaying mesenchymal/sarcomatoid differentiation. We sought to define whether MBCs and UCSs h
Externí odkaz:
https://doaj.org/article/d43d7492291245088deab363a8092b63
Autor:
Fresia Pareja, Alissa H. Brandes, Thais Basili, Pier Selenica, Felipe C. Geyer, Dan Fan, Arnaud Da Cruz Paula, Rahul Kumar, David N. Brown, Rodrigo Gularte-Mérida, Barbara Alemar, Rui Bi, Raymond S. Lim, Ino de Bruijn, Sho Fujisawa, Rui Gardner, Elvin Feng, Anqi Li, Edaise M. da Silva, John R. Lozada, Pedro Blecua, Leona Cohen-Gould, Achim A. Jungbluth, Emad A. Rakha, Ian O. Ellis, Maria I. A. Edelweiss, Juan Palazzo, Larry Norton, Travis Hollmann, Marcia Edelweiss, Brian P. Rubin, Britta Weigelt, Jorge S. Reis-Filho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Granular cell tumors (GCTs) are rare tumors that arise in multiple anatomical locations. Here, the authors investigate the genomics of GCTs, finding inactivating somatic mutations in ATP6AP1 or ATP6AP2 in 72% of the 82 GCTs analyzed. In vitro manipul
Externí odkaz:
https://doaj.org/article/009968388daa46a8b838d3017e34238c
Autor:
Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan Palazzo, Brian P. Rubin, Charlotte K. Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S. Reis-Filho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) sta
Externí odkaz:
https://doaj.org/article/542cf17a65664524a59e8d4c4c40fa5e
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic success of RAF and MEK inhibitors in treating BRAFV600-mutant tumors, a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ff887f10d18c65cb8cab29c0716d78
https://doi.org/10.1158/1541-7786.c.6541189
https://doi.org/10.1158/1541-7786.c.6541189
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
Inhibitors targeting BRAF and its downstream kinase MEK produce robust response in patients with advanced BRAFV600-mutant melanoma. However, the duration and depth of response vary significantly between patients; therefore, predicting response a prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107306fe871b3bcf40d98383381828ba
https://doi.org/10.1158/1535-7163.c.6538579.v1
https://doi.org/10.1158/1535-7163.c.6538579.v1
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
BRAFV600 mutant melanoma PDXs exhibit varied degrees of MAPK pathway suppression upon BRAF and MEK inhibitor treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e9cd4c7279befd5812e90c5288a863
https://doi.org/10.1158/1535-7163.22507099.v1
https://doi.org/10.1158/1535-7163.22507099.v1
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
List of genes from the DEG clustering analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9d56c1e9d561a3296f51346510bda5
https://doi.org/10.1158/1535-7163.22507087.v1
https://doi.org/10.1158/1535-7163.22507087.v1
Autor:
Tinya J. Abrams, Jason S. Damiano, Judith A. Abraham, Paul Kwon, Emma Lees, Nancy K. Pryer, Ursula Jeffry, Katherine G. Rendahl, Thomas Huber, Kathy Miller, Christie P. Fanton, Sylvie Lehmann, William R. Tschantz, GiNell Elliot, Rick Newcombe, Margaret E. McLaughlin, Jane Gu, Felipe C. Geyer, Majid Ghoddusi, Jean-Michel Rondeau, Keith G. Mansfield, Anu Connor, Chi Ying, Suzanna Clark, Angela Tam, Yan Tang, Christopher Karim, Daniel L. Menezes, Joseph A. D'Alessio, Qing Sheng
Figures S1, S2, s3, S4, Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657c2118ddc53bb94cc549cd76abf99c
https://doi.org/10.1158/1535-7163.22521895.v1
https://doi.org/10.1158/1535-7163.22521895.v1
Autor:
Tinya J. Abrams, Jason S. Damiano, Judith A. Abraham, Paul Kwon, Emma Lees, Nancy K. Pryer, Ursula Jeffry, Katherine G. Rendahl, Thomas Huber, Kathy Miller, Christie P. Fanton, Sylvie Lehmann, William R. Tschantz, GiNell Elliot, Rick Newcombe, Margaret E. McLaughlin, Jane Gu, Felipe C. Geyer, Majid Ghoddusi, Jean-Michel Rondeau, Keith G. Mansfield, Anu Connor, Chi Ying, Suzanna Clark, Angela Tam, Yan Tang, Christopher Karim, Daniel L. Menezes, Joseph A. D'Alessio, Qing Sheng
The cell surface glycoprotein P-cadherin is highly expressed in a number of malignancies, including those arising in the epithelium of the bladder, breast, esophagus, lung, and upper aerodigestive system. PCA062 is a P-cadherin specific antibody–dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42af133f07879ce825ff1f600618e03a
https://doi.org/10.1158/1535-7163.c.6543214.v1
https://doi.org/10.1158/1535-7163.c.6543214.v1
Autor:
Darrin D. Stuart, Mariela Jaskelioff, Jeffrey A. Engelman, Alyson K. Freeman, Daniel P. Rakiec, David A. Ruddy, Matthew D. Shirley, Felipe C. Geyer, Frederic D. Sigoillot, Tianshu Feng, Grace P. Leung
Figure S1. Cellular phenotypes observed in response to ERK2 overexpression in A-375 cells. Figure S2. No paracrine effect was produced by cells dying due to knockdown of the essential gene PSMA3. Figure S3. A-375 xenograft tumors with ERK2 overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f0971ae04461a87e039b93d72942c
https://doi.org/10.1158/1541-7786.22515802.v1
https://doi.org/10.1158/1541-7786.22515802.v1