Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

Autor: Alex R Schuurman, Tom DY Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P Scicluna, W Joost Wiersinga, Felipe A Vieira Braga, Tom van der Poll

Publikováno v: eLife, Vol 10 (2021)

The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients wit

Externí odkaz: https://doaj.org/article/86b1440bbe734205ab4a4e76ebe22bbb

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Autor: Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct

Externí odkaz: https://doaj.org/article/369abe186b03465f8bac79e90a4d4606

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Autor: Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural c

Externí odkaz: https://doaj.org/article/9e2c930bc7d3403e9e825b38fb4e38bf

Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin

Autor: Ivan Ramirez-Moral, Alex R. Schuurman, Joe M. Butler, Xiao Yu, Karen de Haan, Sarah van Leeuwen, Alex F. de Vos, Menno D. de Jong, Felipe A. Vieira Braga, Tom van der Poll

Respiratory epithelial cells line the airways and represent the first line of defense against respiratory pathogens. The cellular heterogeneity of the airway wall has only recently been recognized by single-cell analyses. Here, we leveraged single-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e330a9aa2bb3e13286f1d8914caa4725
https://doi.org/10.1101/2022.11.02.514918

Integrated single-cell analysis unveils diverging immune features of covid-19, influenza, and other community-acquired pneumonia

Autor: Anno Saris, Brendon P. Scicluna, Felipe A. Vieira Braga, Louis Vermeulen, Justin de Brabander, Christine van Linge, W. Joost Wiersinga, Ivan Ramirez Moral, Tom van der Poll, Tom D Y Reijnders, Michiel Schinkel, Alex R. Schuurman

Publikováno v: Schuurman, A R, Reijnders, T D Y, Saris, A, Moral, I R, Schinkel, M, de Brabander, J, van Linge, C, Vermeulen, L, Scicluna, B P, Wiersinga, W J, Braga, F A V & van der Poll, T 2021, ' Integrated single-cell analysis unveils diverging immune features of covid-19, influenza, and other community-acquired pneumonia ', eLife, vol. 10, e69661 . https://doi.org/10.7554/eLife.69661
eLife
eLife, 10:e69661. eLife Sciences Publications Limited
eLife, 10:e69661. eLife Sciences Publications
eLife, Vol 10 (2021)

The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadd21f61b618756c55353875d75823c
https://doi.org/10.7554/elife.69661