Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Felipe, Simon"'
Autor:
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
ABSTRACTL-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 p
Externí odkaz:
https://doaj.org/article/46846eaf6bb5405ca5dfca2b249f84b2
Autor:
Cristián Gutiérrez-Vera, Richard García-Betancourt, Pablo A. Palacios, Marioly Müller, David A. Montero, Carlos Verdugo, Francisca Ortiz, Felipe Simon, Alexis M. Kalergis, Pablo A. González, Noemi A. Saavedra-Avila, Steven A. Porcelli, Leandro J. Carreño
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Allergic asthma has emerged as a prevalent allergic disease worldwide, affecting most prominently both young individuals and lower-income populations in developing and developed countries. To devise effective and curative immunotherapy, it is crucial
Externí odkaz:
https://doaj.org/article/55b69705c197419b983dae990d8a8d06
Autor:
Johanna Abrigo, Hugo Olguín, Franco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, Jorge Soto, Mauricio Castro-Sepúlveda, Alvaro A. Elorza, Felipe Simon, Claudio Cabello-Verrugio
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-21 (2023)
Abstract Background Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besides, a mouse model of
Externí odkaz:
https://doaj.org/article/f75b5936269d4a8c8658e7bdc744ec29
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e25081- (2024)
Myeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, including acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and chronic myelomonocytic leukemia. Myeloid neoplastic cells
Externí odkaz:
https://doaj.org/article/b10458d431124248bf80461df02859cf
Autor:
Sabrina Conejeros-Lillo, Francisco Aguirre, Daniel Cabrera, Felipe Simon, Luis Peñailillo, Claudio Cabello-Verrugio
Publikováno v:
European Journal of Translational Myology (2024)
Sarcopenia is characterized by reduced muscle strength and mass and a decline in muscle fiber diameter and amount of sarcomeric proteins. Sarcopenia involves the activation of the ubiquitin-proteasome system (UPS). MuRF-1 and atrogin-1 are E3 ubiquit
Externí odkaz:
https://doaj.org/article/0403944e39d04caa8ddb52f86f99c890
Autor:
Mayalen Valero-Breton, Franco Tacchi, Johanna Abrigo, Felipe Simon, Daniel Cabrera, Claudio Cabello-Verrugio
Publikováno v:
European Journal of Translational Myology (2023)
Skeletal muscle possesses regenerative potential via satellite cells, compromised in muscular dystrophies leading to fibrosis and fat infiltration. Angiotensin II (Ang-II) is commonly associated with pathological states. In contrast, Angiotensin (1-7
Externí odkaz:
https://doaj.org/article/4a8afe798fba42929590a99ea19e1073
Autor:
Josué Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon, Claudio Cabello-Verrugio
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-19 (2023)
Abstract Background Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and decreased strength and
Externí odkaz:
https://doaj.org/article/3b0419d136ad4df585173a92ff297137
Autor:
Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio, Felipe Simon
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-32 (2023)
Abstract Background Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulati
Externí odkaz:
https://doaj.org/article/c033d5e45ec04f8db7623330081fc0fe
Autor:
Antonia Reyes, Gerardo Ortiz, Luisa F. Duarte, Christian Fernández, Rosario Hernández-Armengol, Pablo A. Palacios, Yolanda Prado, Catalina A. Andrade, Linmar Rodriguez-Guilarte, Alexis M. Kalergis, Felipe Simon, Leandro J. Carreño, Claudia A. Riedel, Mónica Cáceres, Pablo A. González
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Cellular senescence is a key biological process characterized by irreversible cell cycle arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can negatively affect tissue functions and may promote the development of
Externí odkaz:
https://doaj.org/article/1681f6a753494ad19037c099d29646e8
Autor:
Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio, Felipe Simon
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/1e0a32b7491f4f75919eca01a9374c45