Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Felicity E, Lumb"'
Autor:
Margaret M. Harnett, Felicity E. Lumb, Jenny Crowe, James Doonan, Geraldine Buitrago, Stephanie Brown, Gillian Thom, Amy MacDonald, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mice develop pathology in the lungs as they age and this may be accelerated by a high calorie diet (HCD). ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is immunomodulatory by virtue of covalently attached phosphorylc
Externí odkaz:
https://doaj.org/article/e3ecfaf3645f4e8596b6d32606f6e458
Autor:
Margaret M. Harnett, James Doonan, Felicity E. Lumb, Jenny Crowe, Roel Olde Damink, Geraldine Buitrago, Josephine Duncombe-Moore, Debbie I. Wilkinson, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant increases in human lifespan over the last century, adoption of high calorie diets (HCD) has driven global increases in type-2 diabetes, obesity and cardiovascular disease, disorders precluding corresponding improvements in healths
Externí odkaz:
https://doaj.org/article/523ab5246f8f4ce380e052b716596cff
Autor:
Marlene Corbet, Miguel A. Pineda, Kun Yang, Anuradha Tarafdar, Sarah McGrath, Rinako Nakagawa, Felicity E. Lumb, Colin J. Suckling, William Harnett, Margaret M. Harnett
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple phosphorylcholine (PC) moieties
Externí odkaz:
https://doaj.org/article/88da2086d64c47acae3e522a690425a6
Autor:
James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Felicity E. Lumb, Jenny Crowe, Aneesah M. Khan, Paul A. Hoskisson, Margaret M. Harnett, William Harnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Gastrointestinal infection with parasitic helminths can protect against mucosal diseases via impacting on the microbiome. Here the authors show that ES-62, a product secreted by a tissue-resident helminth modulates the host gut microbiome to protect
Externí odkaz:
https://doaj.org/article/8765710fbb1b48aea36aa040ff1dbf77
Autor:
Jenny Crowe, Felicity E Lumb, James Doonan, Margaux Broussard, Anuradha Tarafdar, Miguel A Pineda, Carmen Landabaso, Lorna Mulvey, Paul A Hoskisson, Simon A Babayan, Colin Selman, William Harnett, Margaret M Harnett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008391 (2020)
Improvements in hygiene and health management have driven significant increases in human lifespan over the last 50 years. Frustratingly however, this extension of lifespan has not been matched by equivalent improvements in late-life health, not least
Externí odkaz:
https://doaj.org/article/2771c56a5ed84259b37550f07c50890c
Autor:
Felicity E. Lumb, James Doonan, Kara S. Bell, Miguel A. Pineda, Marlene Corbet, Colin J. Suckling, Margaret M. Harnett, William Harnett
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract ES-62, a glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory phenotypes by virtue of covalently attached phosphorylcholine (PC). The PC dictates that ES-
Externí odkaz:
https://doaj.org/article/630b811b03324ca2ba57f8104374c764
Autor:
James Doonan, Felicity E. Lumb, Miguel A. Pineda, Anuradha Tarafdar, Jenny Crowe, Aneesah M. Khan, Colin J. Suckling, Margaret M. Harnett, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The immunomodulatory actions of parasitic helminth excretory-secretory (ES) products that serendipitously protect against development of chronic inflammatory disorders are well established: however, knowledge of the interaction between ES products an
Externí odkaz:
https://doaj.org/article/de354e93f11144c6838ccbf96ced0784
Autor:
James Doonan, David Thomas, Michelle H. Wong, Hazel J. Ramage, Lamyaa Al-Riyami, Felicity E. Lumb, Kara S. Bell, Karen J. Fairlie-Clarke, Colin J. Suckling, Kathrin S. Michelsen, Hui-Rong Jiang, Anne Cooke, Margaret M. Harnett, William Harnett
Publikováno v:
Molecules, Vol 23, Iss 10, p 2669 (2018)
Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein derived from Acanthocheilonema viteae, a filar
Externí odkaz:
https://doaj.org/article/d5805fddbabc4db1868d1305e8b5be66
Autor:
William Harnett, James Doonan, Marlene Corbet, Felicity E. Lumb, Margaret M. Harnett, Miguel A. Pineda
Publikováno v:
Parasite Immunology
Aims ES‐62 is a well‐studied anti‐inflammatory molecule secreted by L4‐adult stage Acanthocheilonema viteae. We maintain the life cycle of A viteae using Meriones libycus as the definitive host. Here, we investigated whether the full life cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f681d704ed7b0e366d161b8c56e74c0c
https://strathprints.strath.ac.uk/74438/7/Lumb_etal_PI_2020_Development_of_Acanthocheilonema_viteae_in_Meriones_shawi.pdf
https://strathprints.strath.ac.uk/74438/7/Lumb_etal_PI_2020_Development_of_Acanthocheilonema_viteae_in_Meriones_shawi.pdf
Autor:
Sarah McGrath, Miguel A. Pineda, Marlene Corbet, Rinako Nakagawa, Kun Yang, William Harnett, Felicity E. Lumb, Margaret M. Harnett, Anuradha Tarafdar
The parasitic worm product, ES-62 protects against collagen-induced arthritis, a mouse model of rheumatoid arthritis (RA) by suppressing the synovial fibroblast (SF) responses perpetuating inflammation and driving joint destruction. Such SF responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22bb45d5a175c339a2259994cd1a896f
https://doi.org/10.1101/2020.10.08.331942
https://doi.org/10.1101/2020.10.08.331942