Using Co-segregation and Loss of Heterozygosity Analysis to Define the Pathogenicity of Unclassified Variants in Hereditary Breast Cancer Patients.

Autor: Grasel RS; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Felicio PS; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., de Paula AE; Center of Molecular Diagnosis, Barretos Cancer Hospital, São Paulo, Brazil., Campacci N; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Garcia FAO; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., de Andrade ES; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Evangelista AF; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Fernandes GC; Center of Molecular Diagnosis, Barretos Cancer Hospital, São Paulo, Brazil., Sabato CDS; Center of Molecular Diagnosis, Barretos Cancer Hospital, São Paulo, Brazil., De Marchi P; Department of Medical Oncology, Barretos Cancer Hospital, São Paulo, Brazil.; Oncoclinicas, Rio de Janeiro, Brazil., Souza CP; Department of Medical Oncology, Barretos Cancer Hospital, São Paulo, Brazil.; Department of Oncogenetics, Barretos Cancer Hospital, São Paulo, Brazil., de Paula CAA; Genomic Diagnostic Center, AC Camargo Cancer Center, São Paulo, Brazil., Torrezan GT; Genomics and Molecular Biology Group, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil., Galvão HCR; Department of Oncogenetics, Barretos Cancer Hospital, São Paulo, Brazil., Carraro DM; Genomic Diagnostic Center, AC Camargo Cancer Center, São Paulo, Brazil.; Genomics and Molecular Biology Group, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil.; Center of Molecular Diagnosis, Barretos Cancer Hospital, São Paulo, Brazil.; Pele Little Prince Research Institute, Curitiba, Brazil.; Faculdades Pequeno Príncipe, Curitiba, Brazil.

Publikováno v: Frontiers in oncology [Front Oncol] 2020 Oct 02; Vol. 10, pp. 571330. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020).

The Brazilian TP53 mutation (R337H) and sarcomas.

Autor: Volc SM; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Ramos CRN; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Galvão HCR; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Felicio PS; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Coelho AS; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Berardineli GN; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Campacci N; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Sabato CDS; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Abrahao-Machado LF; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Santana IVV; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Campanella N; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Lengert AVH; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Barretos Children's Cancer Hospital, Barretos, São Paulo, Brazil., Vidal DO; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Life and Health Sciences Research Institute (ICVS), Health Sciences School, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Dantas CF; Clinical Oncology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Coelho RC; Clinical Oncology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Boldrini E; Barretos Children's Cancer Hospital, Barretos, São Paulo, Brazil., Serrano SV; Clinical Oncology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, São Paulo, Brazil.

Publikováno v: PloS one [PLoS One] 2020 Jan 24; Vol. 15 (1), pp. e0227260. Date of Electronic Publication: 2020 Jan 24 (Print Publication: 2020).

Screening and characterization of BRCA2 c.156_157insAlu in Brazil: Results from 1380 individuals from the South and Southeast.

Autor: Felicio PS; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil. Electronic address: feliciops@hotmail.com., Alemar B; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul. Av. Bento Gonçalves, 9500 - Prédio 43323M. Porto Alegre 91501-970, Rio Grande do Sul, Brazil; Laboratório de Medicina Genômica-Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350. Porto Alegre 90035-903, Rio Grande do Sul, Brazil. Electronic address: barbara.alemar@gmail.com., Coelho AS; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil. Electronic address: alinecoelhobiomed@gmail.com., Berardinelli GN; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil. Electronic address: gnoriz@gmail.com., Melendez ME; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil., Lengert AVH; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil. Electronic address: ahlengert@gmail.com., Miche Lli RD; Department of Oncogenetics, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, Braga 4710-057, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: ruireis.hcb@gmail.com., Fernandes GC; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil. Electronic address: gabriela.carvalhofernandes@gmail.com., Ewald IP; Santa Casa de Misericórdia de Porto Alegre. Av. Independência, 75. Porto Alegre 90035-072, Rio Grande do Sul, Brazil. Electronic address: ipewald@gmail.com., Bittar CM; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul. Av. Bento Gonçalves, 9500 - Prédio 43323M. Porto Alegre 91501-970, Rio Grande do Sul, Brazil; Laboratório de Medicina Genômica-Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350. Porto Alegre 90035-903, Rio Grande do Sul, Brazil. Electronic address: camilambittar@gmail.com., Netto CBO; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre. Rua Ramiro Barcelos, 2350. Porto Alegre 90035-903, Rio Grande do Sul, Brazil. Electronic address: cbnetto@hcpa.edu.br., Artigalas O; Hospital Moinhos de Vento, Rua Ramiro Barcelos, 910. Porto Alegre 91790-560, Rio Grande do Sul, Brazil. Electronic address: artigalas@gmail.com., Peixoto A; Department of Genetics, Portuguese Oncology Institute, R. Dr António Bernardino de Almeida. Porto 4200-072, Portugal. Electronic address: anpeixoto@gmail.com., Pinheiro M; Department of Genetics, Portuguese Oncology Institute, R. Dr António Bernardino de Almeida. Porto 4200-072, Portugal. Electronic address: manuelap@ipoporto.min-saude.pt., Teixeira MR; Department of Genetics, Portuguese Oncology Institute, R. Dr António Bernardino de Almeida. Porto 4200-072, Portugal; Biomedical Sciences Institute Abel Salazar (ICBAS), University of Porto, R. Jorge de Viterbo Ferreira, 228, Porto 4050-313, Portugal. Electronic address: manuelteixeira@ipoporto.min-saude.pt., Vargas FR; Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz (FIOCRUZ), Brazil; Universidade Federal do Estado do Rio de Janeiro, Brazil., Dos Santos ACE; Genetics Program, Instituto Nacional de Câncer, Rua André Cavalcanti, 37. Rio de Janeiro 20231-050, Rio de Janeiro, Brazil., Moreira MAM; Genetics Program, Instituto Nacional de Câncer, Rua André Cavalcanti, 37. Rio de Janeiro 20231-050, Rio de Janeiro, Brazil. Electronic address: miguelm@inca.gov.br., Ashton-Prolla P; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul. Av. Bento Gonçalves, 9500 - Prédio 43323M. Porto Alegre 91501-970, Rio Grande do Sul, Brazil; Laboratório de Medicina Genômica-Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350. Porto Alegre 90035-903, Rio Grande do Sul, Brazil; Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre. Rua Ramiro Barcelos, 2350. Porto Alegre 90035-903, Rio Grande do Sul, Brazil. Electronic address: pprolla@gmail.com., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil; Barretos School of Health Science, Dr. Paulo Prata. Av. Loja Maçonica Renovadora, 68. Barretos 14785-002, São Paulo, Brazil. Electronic address: edenirip@yahoo.com.br.

Publikováno v: Cancer genetics [Cancer Genet] 2018 Dec; Vol. 228-229, pp. 93-97. Date of Electronic Publication: 2018 Oct 06.

Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer.

Autor: Torrezan GT; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil., de Almeida FGDSR; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., Figueiredo MCP; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., Barros BDF; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., de Paula CAA; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., Valieris R; Laboratory of Bioinformatics and Computational Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., de Souza JES; Instituto de Bioinformática e Biotecnologia-2bio, Natal, Brazil.; Instituto Metrópole Digital, Federal University of Rio Grande do Norte, Natal, Brazil.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Natal, Brazil., Ramalho RF; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., da Silva FCC; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil., Ferreira EN; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil.; Research and Development, Fleury Group, São Paulo, Brazil., de Nóbrega AF; Oncogenetics Department, A.C. Camargo Cancer Center, São Paulo, Brazil., Felicio PS; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Achatz MI; Oncogenetics Department, A.C. Camargo Cancer Center, São Paulo, Brazil.; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States., de Souza SJ; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Natal, Brazil.; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, Brazil., Carraro DM; Laboratory of Genomics and Molecular Biology, International Research Center, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil.; National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil.

Publikováno v: Frontiers in genetics [Front Genet] 2018 May 07; Vol. 9, pp. 161. Date of Electronic Publication: 2018 May 07 (Print Publication: 2018).

Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry.

Autor: Fernandes GC; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Michelli RA; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Galvão HC; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Paula AE; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Pereira R; Institute of Research and Innovation in Health, University of Porto, Porto, Portugal.; Institute of Molecular Pathology and Immunology at the University of Porto (IPATIMUP), Porto, Portugal., Andrade CE; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Felicio PS; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Souza CP; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Mendes DR; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Volc S; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Berardinelli GN; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Grasel RS; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Sabato CS; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Viana DV; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Mauad EC; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Prevention Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Scapulatempo-Neto C; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Arun B; MD Anderson Cancer Center, Houston, Texas, USA., Reis RM; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Life and Health Sciences Research Institute (ICVS), Health Sciences School, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal., Palmero EI; Center of Molecular Diagnosis, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Oncogenetics Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, São Paulo, Brazil.

Publikováno v: Oncotarget [Oncotarget] 2016 Dec 06; Vol. 7 (49), pp. 80465-80481.