Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Feliciano, Protasi"'
Autor:
Alessia Di Fonso, Matteo Serano, Miao He, Jennifer Leigh, Giorgia Rastelli, Robert T. Dirksen, Feliciano Protasi, Laura Pietrangelo
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1651 (2024)
Store-operated Ca2+ entry (SOCE) is a ubiquitous cellular mechanism that cells use to activate extracellular Ca2+ entry when intracellular Ca2+ stores are depleted. In skeletal muscle, SOCE occurs within Ca2+ entry units (CEUs), intracellular junctio
Externí odkaz:
https://doaj.org/article/4c2c10cfb01b430eaffc29f7c0f72aaf
Autor:
Genc Berisha, Milan Sedliak, Michal Zeman, Dušan Hamar, Ján Cvečka, Veronika Tirpáková, Matej Vajda, Ľudmila Oreská, Alena Černáčková, Martin Čupka, Nejc Šarabon, Feliciano Protasi, Sandra Zampieri, Helmut Kern, Stefan Lofler, Antonio Musaro, Katarína Stebelová, Monika Okuliarová
Publikováno v:
European Journal of Translational Myology (2023)
A well-synchronized circadian system is a manifestation of an individual's health. A gradual weakening of the circadian timing function characterizes aging. Regular exercise has been suggested as a modality to improve many detrimental changes associa
Externí odkaz:
https://doaj.org/article/7ada1743e02b4f6db6002479d0a364bd
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Ca2+ levels in adult skeletal muscle fibers are mainly controlled by excitation-contraction (EC) coupling, a mechanism that translates action potentials in release of Ca2+ from the sarcoplasmic reticulum (SR) release channels, i.e. the
Externí odkaz:
https://doaj.org/article/644b7a3921524400b62b353d704404d4
Publikováno v:
Biology, Vol 12, Iss 8, p 1064 (2023)
The precise arrangement and peculiar interaction of transverse tubule (T-tubule) and sarcoplasmic reticulum (SR) membranes efficiently guarantee adequate contractile properties of skeletal muscle fibers. Fast muscle fibers from mice lacking calseques
Externí odkaz:
https://doaj.org/article/f4b0e7c90e09406fb96c8e3238fc7aad
Autor:
Alexis Ruiz, Sofia Benucci, Urs Duthaler, Christoph Bachmann, Martina Franchini, Faiza Noreen, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Publikováno v:
eLife, Vol 11 (2022)
To date there are no therapies for patients with congenital myopathies, muscle disorders causing poor quality of life of affected individuals. In approximately 30% of the cases, patients with congenital myopathies carry either dominant or recessive m
Externí odkaz:
https://doaj.org/article/b1a6c6efb1f14c3480eb8053a31a9386
Autor:
Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of
Externí odkaz:
https://doaj.org/article/9c453a3351fb46c1bf8f6e6f7cadf691
Publikováno v:
Cells, Vol 11, Iss 16, p 2468 (2022)
Calsequestrin 1 (CASQ1) and Ryanodine receptor 1 (RYR1) are two of the main players in excitation–contraction (EC) coupling. CASQ1-knockout mice and mice carrying a mutation in RYR1 (Y522S) linked to human malignant hyperthermia susceptibility (MHS
Externí odkaz:
https://doaj.org/article/8a3b0e79c2d54b93973375616cad45ca
Autor:
Gaia Butera, Denis Vecellio Reane, Marta Canato, Laura Pietrangelo, Simona Boncompagni, Feliciano Protasi, Rosario Rizzuto, Carlo Reggiani, Anna Raffaello
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109087- (2021)
Summary: Parvalbumin (PV) is a cytosolic Ca2+-binding protein highly expressed in fast skeletal muscle, contributing to an increased relaxation rate. Moreover, PV is an “atrogene” downregulated in most muscle atrophy conditions. Here, we exploit
Externí odkaz:
https://doaj.org/article/06e492fc39c54bbe9ad2bb2321f44d4b
Autor:
Simona Boncompagni, Claudia Pecorai, Antonio Michelucci, Laura Pietrangelo, Feliciano Protasi
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA myopathy (TAM). TAM is a muscular disease characterized by muscle pain, cramping, and
Externí odkaz:
https://doaj.org/article/87a5a11f0d4b4e6b92e832b934a48720
Publikováno v:
Metabolites, Vol 11, Iss 7, p 424 (2021)
Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasm
Externí odkaz:
https://doaj.org/article/2a9345420b8a42a7b1c6303272378ce7