Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Felicia W. Pagliuca"'
Autor:
Aaron A. Stock, Vita Manzoli, Teresa De Toni, Maria M. Abreu, Yeh-Chuin Poh, Lillian Ye, Adam Roose, Felicia W. Pagliuca, Chris Thanos, Camillo Ricordi, Alice A. Tomei
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 91-104 (2020)
Summary: The scarcity of donors and need for immunosuppression limit pancreatic islet transplantation to a few patients with labile type 1 diabetes. Transplantation of encapsulated stem cell-derived islets (SC islets) might extend the applicability o
Externí odkaz:
https://doaj.org/article/990db46ca54945d5a08440bec6cc563c
Autor:
Jeffrey R. Millman, Chunhui Xie, Alana Van Dervort, Mads Gürtler, Felicia W. Pagliuca, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Pancreatic β cells can be generated from pluripotent stem cells. Here, the authors show that human induced pluripotent stem cells from patients with type 1 diabetes can be differentiated into β-like cells that have no detectable differences compare
Externí odkaz:
https://doaj.org/article/598e2be6e99e4601b6f3ee9c92e2e009
Autor:
Lillian Ye, Aaron A. Stock, Camillo Ricordi, Vita Manzoli, Adam Roose, Felicia W. Pagliuca, Maria M. Abreu, Yeh Chuin Poh, Alice A. Tomei, Chris Thanos, Teresa De Toni
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 91-104 (2020)
Stem Cell Reports
Stem Cell Reports
Summary The scarcity of donors and need for immunosuppression limit pancreatic islet transplantation to a few patients with labile type 1 diabetes. Transplantation of encapsulated stem cell-derived islets (SC islets) might extend the applicability of
Autor:
Henry L. Bushnell, George Harb, Felicia W. Pagliuca, Elad Sintov, Mads Gürtler, Aubrey L. Faust, Quinn P. Peterson, Douglas A. Melton, Jennifer H. R. Kenty, Adrian Veres, Elise N. Engquist, Yeh Chuin Poh
Publikováno v:
Nature. 569:368-373
In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding this differentiation process, we report the transcriptional pr
Autor:
Jeffrey R. Millman, Chunhui Xie, Alana Van Dervort, Mads Gürtler, Felicia W. Pagliuca, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number: 11463 (2016); Published: 10 May 2016; Updated: 4 August 2016. The source of reagents for this Article was not fully acknowledged. The Acknowledgements should have included the following: ‘We thank Professors
Externí odkaz:
https://doaj.org/article/f0c47bb08b0941fabef9494c6fc00cf3
Publikováno v:
Current Transplantation Reports. 4:202-210
Advances in human pluripotent stem cell (hPSC) differentiation protocols have enabled cellular replacement therapies to progress to clinical trials. In patients with Type 1 diabetes (T1D), an autoimmune disease eliminates the majority of islet β cel
Autor:
Douglas A. Melton, Mads Gürtler, Felicia W. Pagliuca, Jeffrey R. Millman, Alana Van Dervort, Chunhui Xie
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Nature Communications
We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 diabetic patients (T1D). β-cells are destroyed during T1D diseas
Autor:
Dale L. Greiner, Siddharth Jhunjhunwala, Joshua C. Doloff, Felicia W. Pagliuca, Jie Li, Arturo J. Vegas, Jeffrey R. Millman, Srujan Gandham, Hok Hei Tam, Daniel G. Anderson, Mads Gürtler, Michael Chen, Gordon C. Weir, Douglas A. Melton, Jose Oberholzer, Andrew Bader, Omid Veiseh, Jennifer Hollister-Lock, Robert Langer, Karsten Olejnik, Matthew A. Bochenek, Erin Langan, James J. McGarrigle, Stephanie Aresta-Dasilva
Publikováno v:
Nature medicine
The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in individuals with diabetes. Pancreas transplantation and the infusion of cadaveric islets are currently implemented clinically, b
Publikováno v:
Cell Therapy ISBN: 9783319571522
Encapsulated beta cell therapy for the treatment of type 1 diabetes remains at the forefront of biomaterials research. With recent success in generating glucoresponsive stem cell-derived β-cells, there is a renewed sense of promise in the field driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526e67b21b112bdd7c8a78b01d2ae40d
https://doi.org/10.1007/978-3-319-57153-9_2
https://doi.org/10.1007/978-3-319-57153-9_2
Autor:
Felicia W. Pagliuca, Douglas A. Melton, Charles W. O'Donnell, Philip diIorio, Francis Deng, Alireza Rezania, David K. Gifford, Sinisa Hrvatin, Jeffrey R. Millman
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3038-3043
Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this end, comparisons between differentiated cell types produced in vitro and their in vivo cou