Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Felicia Giacobbe"'
Autor:
Andrea Cassingena, Alessandro Belotti, Felicia Giacobbe, Alessandra Gambaro, Salvatore Siena, Alessio Amatu, Andrea Sartore-Bianchi, Katia Bencardino, Lisa Pietrogiovanna, Giovanna Marrapese, Filippo Venturini
Publikováno v:
Current Colorectal Cancer Reports. 8:272-276
The introduction into clinical practice of KRAS mutational status for selection of patients has dramatically improved the results from use of anti-EGFR monoclonal antibodies cetuximab or panitumumab for metastatic colorectal cancer. More refined sele
Autor:
Alessio Amatu, Salvatore Siena, Roberta Schiavo, Calogero Lauricella, Andrea Sartore-Bianchi, Alessandro Belotti, Giovanna Marrapese, Felicia Giacobbe, Katia Bencardino, Filippo Venturini, Alessandra Gambaro, Catia Moutinho, Andrea Cassingena, Andrea Sporchia, Manel Esteller
Publikováno v:
Journal of Clinical Oncology. 30:3570-3570
3570 Background: O6-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair protein that removes mutagenic and cytotoxic adducts from O6-guanine in DNA. Roughly 40% of colorectal cancers (CRCs) display MGMT deficiency due to promoter hypermethylat