Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Felicia Gerst"'
Autor:
Morgana Barroso Oquendo, Estela Lorza-Gil, David Juarez-Lopez, Robert Wagner, Andreas L. Birkenfeld, Susanne Ullrich, Felicia Gerst
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Inflammatory cytokines and non-esterified fatty acids (NEFAs) are obesity-linked factors that disturb insulin secretion. The aim of this study was to investigate whether pancreatic adipose tissue (pWAT) is able to generate a NEFA/cytokine ov
Externí odkaz:
https://doaj.org/article/c71efcdfa1ed4ec6b2c53d56e5be1dbd
Autor:
Dorothea Siegel-Axel, Morgana Barroso Oquendo, Felicia Gerst, Falko Fend, Robert Wagner, Martin Heni, Alfred Königsrainer, Hans-Ulrich Häring, Andreas Fritsche, Erwin Schleicher, Andreas L. Birkenfeld, Norbert Stefan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11169 (2023)
Previously, we found that human pancreatic preadipocytes (PPAs) and islets influence each other and that the crosstalk with the fatty liver via the hepatokine fetuin-A/palmitate induces inflammatory responses. Here, we examined whether the mRNA-expre
Externí odkaz:
https://doaj.org/article/b2421575e2654d0f9ed3902695f840a8
Autor:
Francesco Volta, M. Julia Scerbo, Anett Seelig, Robert Wagner, Nils O’Brien, Felicia Gerst, Andreas Fritsche, Hans-Ulrich Häring, Anja Zeigerer, Susanne Ullrich, Jantje M. Gerdes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-proc
Externí odkaz:
https://doaj.org/article/e220d2e988ea4982b89164ece311375a
Autor:
Felicia Gerst, Robert Wagner, Morgana Barroso Oquendo, Dorothea Siegel-Axel, Andreas Fritsche, Martin Heni, Harald Staiger, Hans-Ulrich Häring, Susanne Ullrich
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 1-10 (2019)
Background: It is now generally accepted that obesity is a major risk factor for type 2 diabetes mellitus (T2DM). Hepatic steatosis in particular, as well as visceral and ectopic fat accumulation within tissues, is associated with the development of
Externí odkaz:
https://doaj.org/article/6a160ecb7bd24de290ba6b22c621be76
Autor:
Sibylle Sabrautzki, Gabriele Kaiser, Gerhard K.H. Przemeck, Felicia Gerst, Estela Lorza-Gil, Madhura Panse, Tina Sartorius, Miriam Hoene, Susan Marschall, Hans-Ulrich Häring, Martin Hrabě de Angelis, Susanne Ullrich
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1304-1312 (2017)
Objective: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty
Externí odkaz:
https://doaj.org/article/3aa894d4724e4ddfaf0c209ed2cea638
Autor:
Francesco Volta, M. Julia Scerbo, Anett Seelig, Robert Wagner, Nils O’Brien, Felicia Gerst, Andreas Fritsche, Hans-Ulrich Häring, Anja Zeigerer, Susanne Ullrich, Jantje M. Gerdes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/ed3a5bef20634e758c288f18a6f8a8a4
Autor:
Madhura Panse, Oliver Kluth, Estela Lorza-Gil, Gabriele Kaiser, Eckhard Mühlbauer, Annette Schürmann, Hans-Ulrich Häring, Susanne Ullrich, Felicia Gerst
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198016 (2018)
Glucose and palmitate synergistically stimulate insulin secretion, but chronically elevated they induce apoptotic β-cell death. The glucotoxic effect has been attributed, at least partly, to the upregulation of the oxidative stress marker thioredoxi
Externí odkaz:
https://doaj.org/article/555dd403c1a34f868ba70158f887e395
Autor:
Madhura Panse, Felicia Gerst, Gabriele Kaiser, Charlott-Amélie Teutsch, Rebecca Dölker, Robert Wagner, Hans-Ulrich Häring, Susanne Ullrich
Publikováno v:
Cellular Physiology and Biochemistry, Vol 35, Iss 4, Pp 1537-1545 (2015)
Aims: GPR40/FFAR1 mediates palmitate-induced stimulation of insulin secretion but its involvement in lipotoxicity is controversial. Our previous observations suggest that FFAR1/GPR40 agonists protect against lipotoxicity although the underlying mecha
Externí odkaz:
https://doaj.org/article/ad7d86d967064d6387279cb8941dba1a
Autor:
Norbert Stefan, Qi Sun, Andreas Fritsche, Jürgen Machann, Fritz Schick, Felicia Gerst, Charlotte Jeppesen, Hans-Georg Joost, Frank B Hu, Heiner Boeing, Susanne Ullrich, Hans-Ulrich Häring, Matthias B Schulze
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92238 (2014)
Among adipokines and hepatokines, adiponectin and fetuin-A were consistently found to predict the incidence of type 2 diabetes, both by regulating insulin sensitivity.To determine to what extent circulating adiponectin and fetuin-A are independently
Externí odkaz:
https://doaj.org/article/792b0461bf1c4edb839906db121620fd
Autor:
Stefan, Dorothea Siegel-Axel, Morgana Barroso Oquendo, Felicia Gerst, Falko Fend, Robert Wagner, Martin Heni, Alfred Königsrainer, Hans-Ulrich Häring, Andreas Fritsche, Erwin Schleicher, Andreas L. Birkenfeld, Norbert
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11169
Previously, we found that human pancreatic preadipocytes (PPAs) and islets influence each other and that the crosstalk with the fatty liver via the hepatokine fetuin-A/palmitate induces inflammatory responses. Here, we examined whether the mRNA-expre