Zobrazeno 1 - 10
of 2 444
pro vyhledávání: '"Felice, C."'
Autor:
Fan, Ya Ju, Allen, Jonathan E., McLoughlin, Kevin S., Shi, Da, Bennion, Brian J., Zhang, Xiaohua, Lightstone, Felice C.
Neural Network (NN) models provide potential to speed up the drug discovery process and reduce its failure rates. The success of NN models require uncertainty quantification (UQ) as drug discovery explores chemical space beyond the training data dist
Externí odkaz:
http://arxiv.org/abs/2210.17043
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Autor:
Aydin, Fikret, Georgouli, Konstantia, Dharuman, Gautham, Glosli, James N., Lightstone, Felice C., Ingólfsson, Helgi I., Bremer, Peer-Timo, Bhatia, Harsh
Improved understanding of the relation between the behavior of RAS and RAF proteins and the local lipid environment in the cell membrane is critical for getting insights into the mechanisms underlying cancer formation. In this work, we employ deep le
Externí odkaz:
http://arxiv.org/abs/2207.06630
Autor:
Georgouli, Konstantia, Ingólfsson, Helgi I, Aydin, Fikret, Heimann, Mark, Lightstone, Felice C, Bremer, Peer-Timo, Bhatia, Harsh
Capturing intricate biological phenomena often requires multiscale modeling where coarse and inexpensive models are developed using limited components of expensive and high-fidelity models. Here, we consider such a multiscale framework in the context
Externí odkaz:
http://arxiv.org/abs/2207.04333
Autor:
Gaensbauer, James T., Dash, Nabaneeta, Verma, Sanjay, Hall, DJ, Adler-Shohet, Felice C., Li, Guyu, Lee, Grace, Dinnes, Laura, Wendorf, Kristen
Publikováno v:
In Journal of Clinical Tuberculosis and Other Mycobacterial Diseases August 2024 36
Autor:
Stanton, Liam G., Oppelstrup, Tomas, Carpenter, Timothy S., Ingólfsson, Helgi I., Surh, Michael P., Lightstone, Felice C., Glosli, James N.
We present a continuum model trained on molecular dynamics (MD) simulations for cellular membranes composed of an arbitrary number of lipid types. The model is constructed within the formalism of dynamic density functional theory and can be extended
Externí odkaz:
http://arxiv.org/abs/2112.08651
Autor:
Santucci, D., Vertulli, D., Esperto, F., Eolo Trodella, L., Ramella, S., Papalia, R., Scarpa, R.M., de Felice, C., Francesco Grasso, R., Beomonte Zobel, B., Faiella, E.
Publikováno v:
In Actas Urológicas Españolas (English Edition) March 2024 48(2):140-149