Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

Autor: Weber, Michaela, Sediri, Hanna, Felgenhauer, Ulrike, Binzen, Ina, Bänfer, Sebastian, Jacob, Ralf, Brunotte, Linda, García-Sastre, Adolfo, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Hornung, Veit, Kochs, Georg, Schwemmle, Martin, Klenk, Hans-Dieter, Weber, Friedemann

Publikováno v: In Cell Host & Microbe 11 March 2015 17(3):309-319

Towards the innate immunity phenotype of newly emerging viruses

Autor: Felgenhauer, Ulrike Elke, Justus Liebig University Giessen

The innate immune system, orchestrated by interferons (IFNs), is the host’s first line of defence against intruding viruses. Therefore, pathogenic viruses have evolved a wide variety of IFN-antagonistic strategies. The sensitivity of viruses to IFN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52e09393a7f15cb2ce2a6daba7f403c5

Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies

Autor: Han, Namshik, Hwang, Woochang, Tzelepis, Konstantinos, Schmerer, Patrick, Yankova, Eliza, MacMahon, Méabh, Lei, Winnie, M Katritsis, Nicholas, Liu, Anika, Felgenhauer, Ulrike, Schuldt, Alison, Harris, Rebecca, Chapman, Kathryn, McCaughan, Frank, Weber, Friedemann, Kouzarides, Tony

The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the rapid development of new therapies against coronavirus disease 2019 (COVID-19) infection. Here, we present the identification of 200 approved drugs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f1e1a5e90688be5b86f1bb6d3f5143

Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies.

Autor: Namshik Han¹, Woochang Hwang¹, Tzelepis, Konstantinos¹, Schmerer, Patrick², Eliza Yankova¹, MacMahon, Méabh^1,3, Winnie Lei^1,4, Katritsis, Nicholas M.^1,5, Anika Liu^1,6,7, Felgenhauer, Ulrike², Schuldt, Alison¹, Harris, Rebecca¹, Chapman, Kathryn¹, McCaughan, Frank⁸, Weber, Friedemann², Kouzarides, Tony^1,9

Publikováno v: Science Advances. 6/30/2021, Vol. 7 Issue 27, p1-14. 14p.

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response.

Autor: Shalamova L; Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany., Felgenhauer U; Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany., Wilhelm J; Institute for Lung Health (ILH), Justus-Liebig-University Giessen , D-35392 Giessen, Germany., Schaubmar AR; Unit for Biomathematics and Data processing, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany., Büttner K; Unit for Biomathematics and Data processing, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany., Schoen A; Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany., Widera M; Institute for Medical Virology, University Hospital, Goethe University, D-60596 Frankfurt am Main, Germany., Ciesek S; Institute for Medical Virology, University Hospital, Goethe University, D-60596 Frankfurt am Main, Germany.; German Centre for Infection Research (DZIF), D-35392 Giessen and D-60596 Frankfurt, Germany.; Branch Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), 60596 Frankfurt am Main, Germany., Weber F; Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, D-35392 Giessen, Germany.; German Centre for Infection Research (DZIF), D-35392 Giessen and D-60596 Frankfurt, Germany.

Publikováno v: PNAS nexus [PNAS Nexus] 2022 May 23; Vol. 1 (2), pp. pgac067. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).