Targeting ABL-IRE1 alpha Signaling Spares ER- Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes

Autor: Morita, S, Villalta, SA, Feldman, HC, Register, AC, Rosenthal, W, Hoffmann-Petersen, IT, Mehdizadeh, M, Ghosh, R, Wang, L, Colon-Negron, K, Meza-Acevedo, R, Backes, BJ, Maly, DJ, Bluestone, JA, Papa, FR

Publikováno v: Morita, S; Villalta, SA; Feldman, HC; Register, AC; Rosenthal, W; Hoffmann-Petersen, IT; et al.(2017). Targeting ABL-IRE1 alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes. CELL METABOLISM, 25(4), 883-+. doi: 10.1016/j.cmet.2017.03.018. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6pb6c48s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2a8635a4fa82f9c5e590402fa5551d87
http://www.escholarship.org/uc/item/6pb6c48s

Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats.

Autor: Vozella V; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Cruz B; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Feldman HC; Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA., Bullard R; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Bianchi PC; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil., Natividad LA; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA., Zorrilla EP; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Ciccocioppo R; Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy., Roberto M; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2023 Dec; Vol. 180 (24), pp. 3130-3145. Date of Electronic Publication: 2023 Aug 19.

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.

Autor: Feldman HC; Department of Chemistry, University of Washington, Seattle, WA, USA., Ghosh R; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA., Auyeung VC; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA., Mueller JL; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, University of California, San Francisco, San Francisco, CA, USA., Kim JH; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA., Potter ZE; Department of Chemistry, University of Washington, Seattle, WA, USA., Vidadala VN; Department of Chemistry, University of Washington, Seattle, WA, USA., Perera BGK; Department of Chemistry, University of Washington, Seattle, WA, USA., Olivier A; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA., Backes BJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA., Zikherman J; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, University of California, San Francisco, San Francisco, CA, USA., Papa FR; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. feroz.papa@ucsf.edu.; Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA. feroz.papa@ucsf.edu.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA. feroz.papa@ucsf.edu.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. feroz.papa@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA. feroz.papa@ucsf.edu., Maly DJ; Department of Chemistry, University of Washington, Seattle, WA, USA. djmaly@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, USA. djmaly@uw.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Nov; Vol. 17 (11), pp. 1148-1156. Date of Electronic Publication: 2021 Sep 23.

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Autor: Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR

Publikováno v: Cell metabolism [Cell Metab] 2017 May 02; Vol. 25 (5), pp. 1207.

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.

Autor: Feldman HC; Department of Chemistry, University of Washington , Seattle, Washington, United States., Tong M; Department of Pharmacological Sciences, Stony Brook University Medical School , Stony Brook, New York, United States., Wang L; Department of Medicine, University of California-San Francisco , San Francisco, California, United States.; Diabetes Center, University of California-San Francisco , San Francisco, California, United States.; Lung Biology Center, University of California-San Francisco , San Francisco, California, United States.; California Institute for Quantitative Biosciences, University of California-San Francisco , San Francisco, California, United States., Meza-Acevedo R; Department of Medicine, University of California-San Francisco , San Francisco, California, United States.; Diabetes Center, University of California-San Francisco , San Francisco, California, United States.; Lung Biology Center, University of California-San Francisco , San Francisco, California, United States.; California Institute for Quantitative Biosciences, University of California-San Francisco , San Francisco, California, United States., Gobillot TA; Department of Chemistry, University of Washington , Seattle, Washington, United States., Lebedev I; Department of Pharmacological Sciences, Stony Brook University Medical School , Stony Brook, New York, United States., Gliedt MJ; Department of Medicine, University of California-San Francisco , San Francisco, California, United States.; Lung Biology Center, University of California-San Francisco , San Francisco, California, United States., Hari SB; Department of Chemistry, University of Washington , Seattle, Washington, United States., Mitra AK; Department of Chemistry, University of Washington , Seattle, Washington, United States., Backes BJ; Department of Medicine, University of California-San Francisco , San Francisco, California, United States.; Lung Biology Center, University of California-San Francisco , San Francisco, California, United States., Papa FR; Department of Medicine, University of California-San Francisco , San Francisco, California, United States.; Diabetes Center, University of California-San Francisco , San Francisco, California, United States.; Lung Biology Center, University of California-San Francisco , San Francisco, California, United States.; California Institute for Quantitative Biosciences, University of California-San Francisco , San Francisco, California, United States., Seeliger MA; Department of Pharmacological Sciences, Stony Brook University Medical School , Stony Brook, New York, United States., Maly DJ; Department of Chemistry, University of Washington , Seattle, Washington, United States.; Department of Biochemistry, University of Washington , Seattle, Washington, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2016 Aug 19; Vol. 11 (8), pp. 2195-205. Date of Electronic Publication: 2016 Jun 09.