De novo design of tyrosine and serine kinase-driven protein switches.

Autor: Woodall NB; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Weinberg Z; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Park J; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Busch F; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH, USA., Johnson RS; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Feldbauer MJ; Institute for Protein Design, University of Washington, Seattle, WA, USA., Murphy M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ahlrichs M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Yousif I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., MacCoss MJ; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Wysocki VH; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH, USA., El-Samad H; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Sep; Vol. 28 (9), pp. 762-770. Date of Electronic Publication: 2021 Sep 13.