Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Felcia Lai"'
Autor:
Eric Sparkes, Rochelle Boyd, Shuli Chen, Jack W. Markham, Jia Lin Luo, Tahira Foyzun, Humayra Zaman, Charlotte Fletcher, Ross Ellison, Iain S. McGregor, Marina J. Santiago, Felcia Lai, Roy R. Gerona, Mark Connor, David E. Hibbs, Elizabeth A. Cairns, Michelle Glass, Adam Ametovski, Samuel D. Banister
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Synthetic cannabinoid receptor agonists (SCRAs) continue to make up a significant portion new psychoactive substances (NPS) detected and seized worldwide. Due to their often potent activation of central cannabinoid receptors in vivo, use of SCRAs can
Externí odkaz:
https://doaj.org/article/8bb387539a3c4fa38d68649acedf0eb4
Autor:
Yiqun Chang, Bryson A. Hawkins, Jonathan J. Du, Paul W. Groundwater, David E. Hibbs, Felcia Lai
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 49 (2022)
The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially available product, often due to factors, such as poor binding affinity, off-target effects, o
Externí odkaz:
https://doaj.org/article/2a39dc69ec314f6ca945248d1719c722
Autor:
I Gusti Md Gde Surya C. Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S. Don, George Qian Li, Jane R. Hanrahan, Yanfei Qi
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time with androgen deprivation therapy, 20% of prostate cancers progress to a castration-resist
Externí odkaz:
https://doaj.org/article/9492847f85534f5abe82d4780ead5644
Autor:
Jonathan J. Du, Felcia Lai, Linda Váradi, Peter A. Williams, Paul W. Groundwater, James A. Platts, David E. Hibbs, Jacob Overgaard
Publikováno v:
Crystals, Vol 8, Iss 1, p 46 (2018)
Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic Form II. Form II exhibits improved tabletting properties compared to Form I due to low shearing forces; howe
Externí odkaz:
https://doaj.org/article/eef13055d5d24e92ab20edcc19996e5d
Autor:
Richard C. Kevin, Somayeh Mirlohi, Jamie J. Manning, Rochelle Boyd, Elizabeth A. Cairns, Adam Ametovski, Felcia Lai, Jia Lin Luo, William Jorgensen, Ross Ellison, Roy R. Gerona, David E. Hibbs, Iain S. McGregor, Michelle Glass, Mark Connor, Chris Bladen, Gerald W. Zamponi, Samuel D. Banister
Publikováno v:
ACS Chemical Neuroscience. 13:1395-1409
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29062d567280c9aa4776c3dfdc42dcf4
https://doi.org/10.1021/acschemneuro.1c00822
https://doi.org/10.1021/acschemneuro.1c00822
Autor:
Roy Gerona, Michelle Glass, Marie Deventer, Rochelle Boyd, Shuli Chen, Felcia Lai, Ross Ellison, Lewis J. Martin, Elizabeth A. Cairns, David E. Hibbs, Katharina Elisabeth Grafinger, Eric Sparkes, V. Auwaerter, Samuel D. Banister, Richard C. Kevin, Iain S. McGregor, Christophe P. Stove
Publikováno v:
RSC Med Chem
Synthetic cannabinoid receptor agonists (SCRAs) remain one the most prevalent classes of new psychoactive substances (NPS) worldwide, and examples are generally poorly characterised at the time of first detection. We have synthesised a systematic lib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a320cd7cb08acb3ad4c342d809f21558
https://doi.org/10.1039/d1md00242b
https://doi.org/10.1039/d1md00242b
Autor:
Liesl K. Janssens, Adam Ametovski, Eric Sparkes, Rochelle Boyd, Felcia Lai, Callan J. Maloney, Dane Rhook, Roy R. Gerona, Matthew Connolly, Huiling Liu, David E. Hibbs, Elizabeth A. Cairns, Samuel D. Banister, Christophe P. Stove
Publikováno v:
ACS chemical neuroscience. 14(1)
Over 200 synthetic cannabinoid receptor agonists (SCRAs) have been identified as new psychoactive substances. Effective monitoring and characterization of SCRAs are hindered by the rapid pace of structural evolution. Ahead of possible appearance on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163222e00716076b990b1ce0349b7663
https://pubmed.ncbi.nlm.nih.gov/36530139
https://pubmed.ncbi.nlm.nih.gov/36530139
Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study
Autor:
Jennifer Ong, David E. Hibbs, Gyte Stanton, Bryson A. Hawkins, Stephen A. Stanton, Paul W. Groundwater, James Alexis Platts, Felcia Lai, Jonathan J. Du
Publikováno v:
The Journal of Physical Chemistry A. 125:9736-9756
The charge density distribution in a novel cocrystal (1) complex of 1,3-dimethylxanthine (theophylline) and propanedioic acid (malonic acid) has been determined. The molecules crystallize in the triclinic, centrosymmetric space group P1̅, with four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd59984cbb0f84089569f8f55f86d2
https://doi.org/10.1021/acs.jpca.0c09536
https://doi.org/10.1021/acs.jpca.0c09536
Autor:
Christy El-Khoury, Elissar Mansour, Yori Yuliandra, Felcia Lai, Bryson A. Hawkins, Jonathan J. Du, Eric J. Sundberg, Nicolas Sluis-Cremer, David E. Hibbs, Paul W. Groundwater
Publikováno v:
RSC medicinal chemistry. 13(11)
Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to antibacterial resistance including deactivation of antibacterial agents by bacterial enzymes. Enzymat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ddd311445b31a582f98126828293eb
https://pubmed.ncbi.nlm.nih.gov/36439977
https://pubmed.ncbi.nlm.nih.gov/36439977
Autor:
Bryson A. Hawkins, Elias Najib, Jonathan J. Du, Felcia Lai, James A. Platts, Paul W. Groundwater, David E. Hibbs
This study investigated the effect of 2-methylimidazole (2-MIM) addition on the fluorescence of ethyl-7-hydroxy-2-oxo-2H-chromene-3-carboxylate using low-cost density functional theory (DFT) and Time-Dependent DFT calculations on single crystal X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80277805e19486381f579add680e1ff6
https://orca.cardiff.ac.uk/id/eprint/150819/1/ExploringTheExcited-StateChargeTransferFluorescenceProfileof7-Hydroxycoumarinand2-Methylimidazole_accepted.pdf
https://orca.cardiff.ac.uk/id/eprint/150819/1/ExploringTheExcited-StateChargeTransferFluorescenceProfileof7-Hydroxycoumarinand2-Methylimidazole_accepted.pdf
