Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery

Autor: Schlesinger, Erica B, Bernards, Daniel A, Chen, Hunter H, Feindt, James, Cao, Jingtai, Dix, Daniel, Romano, Carmelo, Bhisitkul, Robert B, Desai, Tejal A

Publikováno v: Bioengineering & translational medicine, vol 4, iss 1

Despite years of effort, sustained delivery of protein therapeutics remains an unmet need due to three primary challenges - dose, duration, and stability. The work presented here provides a design methodology for polycaprolactone reservoir-based thin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::40102513147a3541b4407046000249a4
https://escholarship.org/uc/item/0jf0c4cc

Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery.

Autor: Schlesinger EB; Graduate Program in Bioengineering University of California San Francisco CA 94158.; Formulation Development Group Regeneron Pharmaceuticals Tarrytown NY 10591., Bernards DA; Dept. of Bioengineering and Therapeutic Sciences University of California San Francisco CA 94158., Chen HH; Formulation Development Group Regeneron Pharmaceuticals Tarrytown NY 10591., Feindt J; Formulation Development Group Regeneron Pharmaceuticals Tarrytown NY 10591., Cao J; Ophthalmology Research Regeneron Pharmaceuticals Tarrytown NY 10591., Dix D; Formulation Development Group Regeneron Pharmaceuticals Tarrytown NY 10591., Romano C; Ophthalmology Research Regeneron Pharmaceuticals Tarrytown NY 10591., Bhisitkul RB; Dept. of Ophthalmology University of California San Francisco CA 94158., Desai TA; Graduate Program in Bioengineering University of California San Francisco CA 94158.; Dept. of Bioengineering and Therapeutic Sciences University of California San Francisco CA 94158.

Publikováno v: Bioengineering & translational medicine [Bioeng Transl Med] 2018 Dec 03; Vol. 4 (1), pp. 152-163. Date of Electronic Publication: 2018 Dec 03 (Print Publication: 2019).