Mutational analysis of the role of ADP-ribosylation activity and G(M1)-binding activity in the adjuvant properties of the Escherichia coli heat-labile enterotoxin towards intranasally administered keyhole limpet hemocyanin

Autor: de Haan, L, Feil, IK, Verweij, WR, Holtrop, M, Hol, WGJ, Agsteribbe, E, Wilschut, J

Publikováno v: European Journal of Immunology, 28(4), 1243-1250. Wiley

The Escherichia coli heat-labile enterotoxin (LT) is known for its potent mucosal immunoadjuvant activity towards co-administered antigens. LT is composed of one A subunit, which has ADP-ribosylation activity, and a homopentameric B subunit, which ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4c0403e3641a1c408d9399fbe7bf3c00
https://research.rug.nl/en/publications/56fd104d-252a-4e70-8c04-8849b59f08ce

Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity

Autor: Feil, IK, Reddy, R, deHaan, L, Merritt, EA, vandenAkker, F, Storm, DR, Hol, WGJ

Publikováno v: Molecular Microbiology, 20(4), 823-832. Wiley

Heat-labile enterotoxin (LT), produced by enterotoxigenic Escherichia coli, is a close relative of cholera toxin (CT), These two toxins share approximately 80% sequence identity, and consists of one 240-residue A chain and five 103-residue B subunits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2c3734dc22ddabc5163709363ea0f307
https://research.rug.nl/en/publications/344a38ea-6fec-431b-80f6-3afdad5e8906

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Stepwise transplantation of an active site loop between heat-labile enterotoxins LT-II and LT-I and characterization of the obtained hybrid toxins

Autor: Feil, IK, Platas, AA, van den Akker, F, Reddy, R, Merritt, EA, Storm, DR, Hol, WGJ

Publikováno v: Protein Engineering Design and Selection; November 1998, Vol. 11 Issue: 11 p1103-1109, 7p

Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit.

Autor: de Haan L; Department of Physiological Chemistry, Groningen Utrecht Institute for Drug Exploration (GUIDE), University of Groningen, The Netherlands., Verweij WR, Feil IK, Holtrop M, Hol WG, Agsteribbe E, Wilschut J

Publikováno v: Immunology [Immunology] 1998 Jul; Vol. 94 (3), pp. 424-30.