Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Feijie Zhang"'
Autor:
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Mark A. Kay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to t
Externí odkaz:
https://doaj.org/article/d62aaf6b8f6e41b794d5bf3b8b68ef81
Autor:
Francesco Puzzo, Chuanling Zhang, Bethany Powell Gray, Feijie Zhang, Bruce A. Sullenger, Mark A. Kay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 383-397 (2023)
Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue. Here, we developed new chemically modified AAV
Externí odkaz:
https://doaj.org/article/2cb14785ab9043a29a90dad688519651
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 73-88 (2022)
A limitation for recombinant adeno-associated virus (rAAV)-mediated gene transfer into the central nervous system (CNS) is the low penetration of vectors across the human blood-brain barrier (BBB). High doses of intravenously delivered vector are req
Externí odkaz:
https://doaj.org/article/86db400fe64f437aa8bcb31f674ac266
Autor:
Paul N. Valdmanis, Hak Kyun Kim, Kirk Chu, Feijie Zhang, Jianpeng Xu, Elizabeth M. Munding, Jia Shen, Mark A. Kay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
miR-122 is a highly expressed microRNA in the liver. Here the authors analyse the mouse liver microRNA landscape following depletion of miR-122 and the impact that this has on its target mRNAs.
Externí odkaz:
https://doaj.org/article/bce2ee1a64f046a383d8e6d4a3be7c1a
Autor:
Adriana Gonzalez-Sandoval, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Katja Pekrun, Mark A. Kay
SummaryRecombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afc5f19319580a17325b00e92022021
https://doi.org/10.1101/2022.10.06.511169
https://doi.org/10.1101/2022.10.06.511169
Autor:
Shinnosuke Tsuji, Calvin J. Stephens, Giulia Bortolussi, Feijie Zhang, Gabriele Baj, Hagoon Jang, Gustavo de Alencastro, Andrés F. Muro, Katja Pekrun, Mark A. Kay
Homologous recombination (HR)-based gene therapy using adeno-associated viruses (AAV-HR) without nucleases has several advantages over classic gene therapy, especially the potential for permanent transgene expression. However, the low efficiency of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b28977fb37869e8d09fd780d2efe38
http://hdl.handle.net/11368/3026084
http://hdl.handle.net/11368/3026084
Autor:
Mary P. Hall, Mark A. Kay, Yunhee Park, Joel R. Walker, Lan Xiang Liu, Louai Labanieh, Robbie G. Majzner, Namdoo Kim, Michael Z. Lin, Lance P. Encell, Jennifer R. Cochran, Kerriann M. Casey, David C. Wang, Robin Hurst, Yichi Su, Thomas A. Kirkland, Feijie Zhang, Crystal L. Mackall, Thomas P. Smith
Publikováno v:
Nature Methods. 17:852-860
Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a bright bioluminescent reporter with orthogonal
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 40(11)
In the present study, chinonomus riparius larvae were selected as a model organism, and 11 sediment samples from the Xihe River in Shenyang underwent toxicity identification evaluation (TIE) to identify sediment toxic pollutants. Heavy metals and org
Autor:
Gustavo de Alencastro, Giulia Bortolussi, Mark A. Kay, Calvin Stevens, Andrés F. Muro, Feijie Zhang, Katja Pekrun, Shinnosuke Tsuji, Gabriele Baj
Recombinant adeno-associated viral (rAAV) vectors continue to gain popularity for in vivo therapeutic gene delivery. Homologous recombination-based gene therapy using rAAV (AAV-HR) without nucleases has several advantages over classical gene therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221c0e61e18c7cc9a70c91495bb3b422
https://doi.org/10.21203/rs.3.rs-106148/v1
https://doi.org/10.21203/rs.3.rs-106148/v1
Autor:
Feijie Zhang, Matthew Tiffany, Ruhikanta A. Meetei, M. Kyle Cromer, Karim Majzoub, Mara Pavel-Dinu, Sirika Pillay, Adam Sheikali, Jan E. Carette, Mark A. Kay, Katja Pekrun, Francesco Puzzo, Hagoon Jang, Gustavo de Alencastro, Matthew H. Porteus
Publikováno v:
Mol Ther
Recombinant adeno-associated virus (rAAV) vectors have the unique property of being able to perform genomic targeted integration (TI) without inducing a double-strand break (DSB). In order to improve our understanding of the mechanism behind TI media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35065181d1261c0a3966f7b32e3ee768
https://europepmc.org/articles/PMC7934449/
https://europepmc.org/articles/PMC7934449/