Spliced-Leader RNA as a Dynamic Marker for Monitoring Viable Leishmania Parasites During and After Treatment.

Autor: Hendrickx R; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Melkamu R; Leishmaniasis Research and Treatment Center, University of Gondar Hospital, Gondar., Tadesse D; College of Medicine and Health Sciences, Arba Minch University., Teferi T; Malaria and Leishmaniasis Research and Treatment Center, Arba Minch General Hospital, Arba Minch, Ethiopia., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Vleminckx M; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., van Henten S; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium., Alves F; Drugs for Neglected Diseases initiative, Geneva, Switzerland., Shibru T; College of Medicine and Health Sciences, Arba Minch University., van Griensven J; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium., Pareyn M; Clinical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. 183-187.

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc 1 .

Autor: Braillard S; Drugs for Neglected Diseases initiative (DNDi), Chemin Camille-Vidart 15, 1202 Geneva, Switzerland., Keenan M; Epichem Pty Ltd., Perth, Western Australia, Australia., Breese KJ; Epichem Pty Ltd., Perth, Western Australia, Australia., Heppell J; Epichem Pty Ltd., Perth, Western Australia, Australia., Abbott M; Epichem Pty Ltd., Perth, Western Australia, Australia., Islam R; Epichem Pty Ltd., Perth, Western Australia, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Crighton E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Patil R; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Lee G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Carvalho S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Wall RJ; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Chemi G; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., González S; Global Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Marco M; Global Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Deakyne J; Global Investigative Safety, GSK, Collegeville, PA, USA., Standing D; Medicine Design, GSK, Stevenage, UK., Brunori G; Global Investigative Safety, GSK, Ware, UK., Lyon JJ; Global Investigative Safety, GSK, Ware, UK., Castañeda-Casado P; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Camino I; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Martinez Martinez MS; Discovery DMPK, GSK, Tres Cantos, Madrid, Spain., Zulfiqar B; Discovery Biology, Griffith University, Nathan, Queensland 4111, Australia., Avery VM; Discovery Biology, Griffith University, Nathan, Queensland 4111, Australia., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Van Pelt N; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Hendrickx S; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium., Yardley V; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK., Wyllie S; Wellcome Centre for Anti-infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Chatelain E; Drugs for Neglected Diseases initiative (DNDi), Chemin Camille-Vidart 15, 1202 Geneva, Switzerland.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Dec 13; Vol. 15 (726), pp. eadh9902. Date of Electronic Publication: 2023 Dec 13.

Exploration of 6-methyl-7-(Hetero)Aryl-7-Deazapurine ribonucleosides as antileishmanial agents.

Autor: Lin C; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium., Karalic I; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Feijens PB; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Hulpia F; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium., Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1 (S7), B-2610, Wilrijk, Belgium. Electronic address: guy.caljon@uantwerpen.be., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address: serge.vancalenbergh@ugent.be.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Jul 05; Vol. 237, pp. 114367. Date of Electronic Publication: 2022 Apr 25.

Evaluation of Loopamp Leishmania detection kit for the diagnosis of cutaneous leishmaniasis in Ethiopia.

Autor: Taye, Behailu^1,2 (AUTHOR) behailutaye096@gmail.com, Melkamu, Roma³ (AUTHOR), Tajebe, Fitsumbrhan¹ (AUTHOR), Ibarra-Meneses, Ana Victoria⁴ (AUTHOR), Adane, Desalegn³ (AUTHOR), Atnafu, Saba³ (AUTHOR), Adem, Mohammed¹ (AUTHOR), Adane, Gashaw¹ (AUTHOR), Kassa, Mekibib³ (AUTHOR), Asres, Mezgebu Silamsaw³ (AUTHOR), van Griensven, Johan⁵ (AUTHOR), van Henten, Saskia⁵ (AUTHOR), Pareyn, Myrthe⁵ (AUTHOR)

Publikováno v: Parasites & Vectors. 10/15/2024, Vol. 17 Issue 1, p1-8. 8p.

PLGA nanoparticles and nanosuspensions with amphotericin B: Potent in vitro and in vivo alternatives to Fungizone and AmBisome.

Autor: Van de Ven H; Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp-Wilrijk, Belgium. helene.vandeven@ua.ac.be, Paulussen C, Feijens PB, Matheeussen A, Rombaut P, Kayaert P, Van den Mooter G, Weyenberg W, Cos P, Maes L, Ludwig A

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Aug 10; Vol. 161 (3), pp. 795-803. Date of Electronic Publication: 2012 May 26.