Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Feihan F Dai"'
Publikováno v:
eLife, Vol 9 (2020)
Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up
Externí odkaz:
https://doaj.org/article/4795b0d92c894aa1af5cabc1a7ba37e0
Autor:
Mi Lai, Ying Liu, Gabriele V Ronnett, Anne Wu, Brian J Cox, Feihan F Dai, Hannes L Röst, Erica P Gunderson, Michael B Wheeler
Publikováno v:
PLoS Medicine, Vol 17, Iss 5, p e1003112 (2020)
BACKGROUND:Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk of developing hypertension and cardiovascular disease. Glucose tolerance reclassi
Externí odkaz:
https://doaj.org/article/7e9636479dfc4a6a918ea8161fc6903d
Autor:
Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129226 (2015)
Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important to unders
Externí odkaz:
https://doaj.org/article/a19615632d2d4745b3ae5d21afc23784
Autor:
Mi Lai, Stacey E. Alexeeff, Hannes L. Röst, Ziyi Zhang, Michael B. Wheeler, Feihan F. Dai, Amina Allalou, Erica P. Gunderson, Anthony L. Piro
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-21 (2021)
BMC Medicine
BMC Medicine
BackgroundWomen with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D). It is estimated that 20-50% of women with GDM history will progress to T2D within 10 years after delivery. Intensive
Autor:
Ziyi Zhang, Anthony L Piro, Amina Allalou, Stacey E Alexeeff, Feihan F Dai, Erica P Gunderson, Michael B Wheeler
Publikováno v:
J Clin Endocrinol Metab
Context Prolactin is a multifaceted hormone known to regulate lactation. In women with gestational diabetes mellitus (GDM) history, intensive lactation has been associated with lower relative risk of future type 2 diabetes (T2D). However, the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a973758c3814e979853268886a2a0d
https://europepmc.org/articles/PMC9387721/
https://europepmc.org/articles/PMC9387721/
Autor:
Alpana Bhattacharjee, Ashley Untereiner, Jie Xu, Feihan F. Dai, Cheng Hu, Over Cabrera, Michael B. Wheeler
Publikováno v:
Diabetes, Obesity and Metabolism. 22:2021-2031
Aim To examine the mechanism of action of γ-aminobutyric acid (GABA) on β-cell proliferation and investigate if co-treatment with Ly49, a novel GABA type A receptor positive allosteric modulator (GABAA -R PAM), amplifies this effect. Methods Human
Publikováno v:
Frontiers in endocrinology. 13
ObjectivePregnancy is a dynamic state involving multiple metabolic adaptions in various tissues including the endocrine pancreas. However, a detailed characterization of the maternal islet metabolome in relation to islet function and the ambient circ
Autor:
Anne Wu, Francisco J. Schopfer, Dana Al Rijjal, Haneesha Mohan, Michael B. Wheeler, Youchen Song, Li Wei, Ying Liu, Feihan F. Dai, Mi Lai, Zahra Danaei
Publikováno v:
iScience
iScience, Vol 24, Iss 8, Pp 102909-(2021)
iScience, Vol 24, Iss 8, Pp 102909-(2021)
Summary Omega-3 fatty acid prescription drugs, Vascepa (≥96% eicosapentaenoic acid [EPA] ethyl ester) and Lovaza (46.5% EPA and 37.5% docosahexaenoic acid ethyl ester) are known therapeutic regimens to treat hypertriglyceridemia. However, their imp
Autor:
Dana Al Rijjal, Jie Xu, Alpana Bhattacharjee, Paul E. Fraser, Ying Liu, Michael B. Wheeler, Anthony L. Piro, Nadeeja Wijesekara, Cheng Hu, Romario Regeenes, Jonathan V. Rocheleau, Youchen Song, Lucy Marzban, Feihan F. Dai, Anne Wu
Publikováno v:
JCI Insight
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to earlier work in humans and mouse models. Therefore,
Autor:
Jonathan V. Rocheleau, Carl Virtanen, Ying Liu, Dana Al Rijjal, Shaaban Abdo, Michael B. Wheeler, Battsetseg Batchuluun, Beverley A. Orser, Anthony Wong, Neil Winegarden, Ashley Untereiner, Gabor Varga, Mi Lai, Over Cabrera, Farzaneh Pourasgari, Nicholas Khuu, Feihan F. Dai, Alpana Bhattacharjee, Himaben Gohil, Neke Ibeh
Publikováno v:
The FASEB Journal. 33:3968-3984
γ-Aminobutyric acid (GABA) administration has been shown to increase β-cell mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has any effect on β cells of healthy and prediabetic/glucose-intolerant obese mice remains unknown. In