Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fei-Yue Zhao"'
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 54-71 (2020)
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://doaj.org/article/090fce1d57f8401b9e992de5fd12af30
Publikováno v:
Journal of the Formosan Medical Association, Vol 109, Iss 6, Pp 438-445 (2010)
Rats display behavioral signs of neuropathic pain lasting for months in the chronic constriction injury (CCI) model. During intrathecal anesthesia, the administered drugs mainly diffuse directly into the superficial neurons in the spinal dorsal horn.
Externí odkaz:
https://doaj.org/article/dc4b653766cc48a4a478e8d813efd369
Autor:
Sandeep Chhabra, Simon G. Gooding, Alessia Belgi, Raymond S. Norton, David J. Adams, Samuel D. Robinson, James Burnley, Peter Bartels, Fei Yue Zhao, David Spanswick, Andrea J. Robinson, Khaled A. Elnahriry, Mahsa Sadeghi, Han-Shen Tae, Christopher A. MacRaild, Haifeng Wei
Publikováno v:
Journal of Medicinal Chemistry. 64:3222-3233
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest. Modification of the interlocked disulfide framework of α-conotoxin Vc1.1 has been achieved usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e7ff4e2677bf08f7477ed2e2896f72
https://doi.org/10.1021/acs.jmedchem.0c02151
https://doi.org/10.1021/acs.jmedchem.0c02151
Autor:
Garron T. Dodd, David P De Souza, Russell D Brown, David Spanswick, Vanessa R. Haynes, Marco van den Top, Natalie J. Michael, Fei-Yue Zhao, Matthew J. Watt
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Objectives Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ae996a2befbf98fb187500b5a9cbd
https://doi.org/10.1016/j.molmet.2020.01.002
https://doi.org/10.1016/j.molmet.2020.01.002
Autor:
Matthew J. Sykes, Wendy L. Imlach, Orsolya Kékesi, Yan T. Wong, Fei Yue Zhao, David Spanswick
Publikováno v:
Neuropharmacology. 198
Excitatory and inhibitory neurotransmission within the spinal dorsal horn is tightly controlled to regulate transmission of nociceptive signals to the brain. One aspect of this control is modulation of neuronal activity through cholinergic signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5220aa2cc7b07b4915dcf5e7318a6a
https://pubmed.ncbi.nlm.nih.gov/34416268
https://pubmed.ncbi.nlm.nih.gov/34416268
Autor:
Mark J, Wall, Emily, Hill, Robert, Huckstepp, Kerry, Barkan, Giuseppe, Deganutti, Michele, Leuenberger, Barbara, Preti, Ian, Winfield, Sabrina, Carvalho, Anna, Suchankova, Haifeng, Wei, Dewi, Safitri, Xianglin, Huang, Wendy, Imlach, Circe, La Mache, Eve, Dean, Cherise, Hume, Stephanie, Hayward, Jess, Oliver, Fei-Yue, Zhao, David, Spanswick, Christopher A, Reynolds, Martin, Lochner, Graham, Ladds, Bruno G, Frenguelli
Publikováno v:
Nature communications. 13(1)
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa941f335f351aaf8baa573ea9efddc
https://pubmed.ncbi.nlm.nih.gov/35851064
https://pubmed.ncbi.nlm.nih.gov/35851064
Publikováno v:
Zhongguo shi yan xue ye xue za zhi. 25(2)
To explore the expression of death-associated protein kinase 1(DAPK1) in chronic lymphocytic leukemia(CLL).The DAPK1 expression was studied by means of MEC1 cells and B lymphocytes from blood samples of the patients with CLL. The quantitative detecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae95480936b25b0bdf50b4d7451e6f29
https://pubmed.ncbi.nlm.nih.gov/28446269
https://pubmed.ncbi.nlm.nih.gov/28446269
Publikováno v:
Pain. 128:78-87
There are several lines of evidence to suggest that cyclooxygenase-2 (COX-2) plays an important role in the generation and maintenance of neuropathic pain states following peripheral nerve injury. However, COX-2 inhibitors are generally ineffective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dc57751135097aabf41cb7c67a2ba0
https://doi.org/10.1016/j.pain.2006.08.032
https://doi.org/10.1016/j.pain.2006.08.032
In Vivo Electrophysiological Recording Techniques for the Study of Neuropathic Pain in Rodent Models
Publikováno v:
Current Protocols in Pharmacology
Neuropathic pain develops following nerve injury, and is a chronic pain syndrome that can persist long after repair of a wound or removal of the neurological insult. This condition remains poorly treated, not least because of a lack of mechanism-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b51ba4b015de6c2af8314485a86041c
https://doi.org/10.1002/0471141755.ph1115s66
https://doi.org/10.1002/0471141755.ph1115s66