Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Fei-Yue Zhao"'
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 54-71 (2020)
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://doaj.org/article/090fce1d57f8401b9e992de5fd12af30
Autor:
Sandeep Chhabra, Simon G. Gooding, Alessia Belgi, Raymond S. Norton, David J. Adams, Samuel D. Robinson, James Burnley, Peter Bartels, Fei Yue Zhao, David Spanswick, Andrea J. Robinson, Khaled A. Elnahriry, Mahsa Sadeghi, Han-Shen Tae, Christopher A. MacRaild, Haifeng Wei
Publikováno v:
Journal of Medicinal Chemistry. 64:3222-3233
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest. Modification of the interlocked disulfide framework of α-conotoxin Vc1.1 has been achieved usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e7ff4e2677bf08f7477ed2e2896f72
https://doi.org/10.1021/acs.jmedchem.0c02151
https://doi.org/10.1021/acs.jmedchem.0c02151
Autor:
Garron T. Dodd, David P De Souza, Russell D Brown, David Spanswick, Vanessa R. Haynes, Marco van den Top, Natalie J. Michael, Fei-Yue Zhao, Matthew J. Watt
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Objectives Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ae996a2befbf98fb187500b5a9cbd
https://doi.org/10.1016/j.molmet.2020.01.002
https://doi.org/10.1016/j.molmet.2020.01.002
Publikováno v:
Journal of the Formosan Medical Association, Vol 109, Iss 6, Pp 438-445 (2010)
Rats display behavioral signs of neuropathic pain lasting for months in the chronic constriction injury (CCI) model. During intrathecal anesthesia, the administered drugs mainly diffuse directly into the superficial neurons in the spinal dorsal horn.
Externí odkaz:
https://doaj.org/article/dc4b653766cc48a4a478e8d813efd369
Autor:
Matthew J. Sykes, Wendy L. Imlach, Orsolya Kékesi, Yan T. Wong, Fei Yue Zhao, David Spanswick
Publikováno v:
Neuropharmacology. 198
Excitatory and inhibitory neurotransmission within the spinal dorsal horn is tightly controlled to regulate transmission of nociceptive signals to the brain. One aspect of this control is modulation of neuronal activity through cholinergic signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5220aa2cc7b07b4915dcf5e7318a6a
https://pubmed.ncbi.nlm.nih.gov/34416268
https://pubmed.ncbi.nlm.nih.gov/34416268
Autor:
Mark J, Wall, Emily, Hill, Robert, Huckstepp, Kerry, Barkan, Giuseppe, Deganutti, Michele, Leuenberger, Barbara, Preti, Ian, Winfield, Sabrina, Carvalho, Anna, Suchankova, Haifeng, Wei, Dewi, Safitri, Xianglin, Huang, Wendy, Imlach, Circe, La Mache, Eve, Dean, Cherise, Hume, Stephanie, Hayward, Jess, Oliver, Fei-Yue, Zhao, David, Spanswick, Christopher A, Reynolds, Martin, Lochner, Graham, Ladds, Bruno G, Frenguelli
Publikováno v:
Nature communications. 13(1)
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa941f335f351aaf8baa573ea9efddc
https://pubmed.ncbi.nlm.nih.gov/35851064
https://pubmed.ncbi.nlm.nih.gov/35851064
In Vivo Electrophysiological Recording Techniques for the Study of Neuropathic Pain in Rodent Models
Publikováno v:
Current Protocols in Pharmacology
Neuropathic pain develops following nerve injury, and is a chronic pain syndrome that can persist long after repair of a wound or removal of the neurological insult. This condition remains poorly treated, not least because of a lack of mechanism-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b51ba4b015de6c2af8314485a86041c
https://doi.org/10.1002/0471141755.ph1115s66
https://doi.org/10.1002/0471141755.ph1115s66
Publikováno v:
The Journal of Physiology. 511:871-886
We examined the steady-state summation of postsynaptic potentials (PSPs) in small, electrotonically compact neurones with short dendrites, using a one-compartment electrical equivalent model of the passive membrane with conductances to represent chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f4a0a8f6b62d95ce86027f9e5d0e48
https://doi.org/10.1111/j.1469-7793.1998.871bg.x
https://doi.org/10.1111/j.1469-7793.1998.871bg.x
Autor:
Xin Fang, Bowen Carrie A, Fei-Yue Zhao, David Spanswick, Haifeng Wei, Seth C. Hopkins, Michelle L. R. Heffernan, Thomas H. Large, Mark A. Varney, Kerry L. Spear
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 345(3)
Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the effects of systemic administration of the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid (SUN) in rat models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5427c67cbcf3216cac4cac0d38628bd
https://pubmed.ncbi.nlm.nih.gov/23520265
https://pubmed.ncbi.nlm.nih.gov/23520265