Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fei F. Shih"'
Autor:
Hong Lu, Xiaodong Zhou, Peter Weiser, Lijuan Zhang, Fei F. Shih, Jing Pan, Yi Qian, Anne M. Beck
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis. 16:261-265
Autor:
Hong Lu, Jing Pan, Rhonda Porche-Sorbet, Charles S. Eby, Xiaodong Zhou, Peter Weiser, Lijuan Zhang, Yi Qian, Fei F. Shih
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis. 16:251-260
Heparin-induced thrombocytopenia with thrombosis (HITT) is the most severe side effect of heparin administration. Patients with HITT may die or have permanent sequelae such as stroke or limb amputation. Contaminated heparin is associated with anaphyl
Publikováno v:
Arthritis & Rheumatism. 58:3730-3741
Objective CD4+CD25+FoxP3+ regulatory T (Treg) cells are critical regulators of autoimmunity. Yet the number of Treg cells is paradoxically increased in rheumatoid arthritis (RA) patients, and Treg cells show variable activity in human studies. The ob
Publikováno v:
The Journal of Immunology. 176:3438-3448
Glucose-6-phosphate isomerase (GPI) is the target autoantigen recognized by KRN T cells in the K/BxN model of rheumatoid arthritis. T cell reactivity to this ubiquitous Ag results in the recruitment of anti-GPI B cells and subsequent immune complex-m
Autor:
Fei F. Shih, Paul M. Allen
Publikováno v:
Molecular Immunology. 40:1041-1046
In this review, we dissect two different antigen systems which represent the apparent extremes of T cell receptor (TCR) recognition. In the hemoglobin (Hb) system, a minor change in a single MHC anchor residue disrupts TCR recognition. In the KRN sys
Autor:
Andria L. Petrone, Fei F. Shih, Douglas M. Cerasoli, Michael P. Riley, Martha S. Jordan, Andrew J. Caton, Phillip Scott
Publikováno v:
European Journal of Immunology. 31:311-319
We have examined factors governing the differentiation of autoreactive CD4+ T cells that have evaded deletion by a self peptide. Two lineages of transgenic mice (HA12 and HA104) expressing the influenza virus hemagglutinin (HA) were mated with TS1 mi
Autor:
Andrew J. Caton, Andria L. Petrone, Martha S. Jordan, Douglas M. Cerasoli, Fei F. Shih, Michael P. Riley
Publikováno v:
The Journal of Immunology. 165:4870-4876
We have examined factors governing the negative selection of autoreactive CD4+ T cells in transgenic mice expressing low (HA12 mice) vs high (HA104 mice) amounts of the influenza virus hemagglutinin (HA). When mated with TS1 mice that express a trans
Publikováno v:
Immunologic Research. 17:23-32
To analyze mechanisms governing tolerance and autoimmunity to self-antigens, we have generated lineages of transgenic mice that express the influenza virus PR8 hemagglutinin (HA) as a neo-self-antigen. By comparing the HA-specific T and B cell respon
Publikováno v:
Journal of Clinical Immunology. 15:S106-S112
We have generated transgenic mouse lineages that express the influenza virus hemagglutinin in different physical forms. One kind expresses the full-length hemagglutinin molecule as a cell surface glycoprotein and can be recognized by hemagglutinin-sp
Publikováno v:
The Journal of Experimental Medicine
We have analyzed the genetic basis for T cell recognition of an endogenous major histocompatibility complex class II-restricted self peptide. Transgenic mice expressing the influenza virus PR8 hemagglutinin I-Ed-restricted determinant S1 (HA Tg mice)