Výsledky vyhledávání - "Fehad J. Khan"

Akademický článek

Multiplexed CRISPR/Cas9 gene knockout with simple crRNA:tracrRNA co-transfection

Autor: Fehad J. Khan, Garmen Yuen, Ji Luo

Publikováno v: Cell & Bioscience, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract Background CRISPR/Cas9 mediated gene knockout is a powerful tool for genome editing with the ability to target multiple genes simultaneously. Establishing an efficient, multiplexed gene knockout system using CRISPR/Cas9 that is both simple a

Externí odkaz: https://doaj.org/article/0d9b3a28fdde4abfad4fae1c856f63e8

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CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level

Autor: Ji Luo, Xiaolin Wu, Jayne M. Stommel, Fehad J. Khan, Eric Batchelor, Garmen Yuen, Shaojian Gao

Publikováno v: Nucleic Acids Research

CRISPR/Cas9 is a powerful gene editing tool for gene knockout studies and functional genomic screens. Successful implementation of CRISPR often requires Cas9 to elicit efficient target knockout in a population of cells. In this study, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccac972dae345043145c3289b86f7486
http://europepmc.org/articles/PMC5714203

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