Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.

Autor: Lenoir WF; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Morgado M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., DeWeirdt PC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McLaughlin M; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Griffith AL; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sangree AK; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Feeley MN; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Esmaeili Anvar N; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim E; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bertolet LL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Colic M; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dede M; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hart T; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. traver@hart-lab.org.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. traver@hart-lab.org.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 11; Vol. 12 (1), pp. 6506. Date of Electronic Publication: 2021 Nov 11.

Massively parallel assessment of human variants with base editor screens.

Autor: Hanna RE; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Hegde M; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Fagre CR; Cancer Program, Broad Institute, Cambridge, MA 02142, USA., DeWeirdt PC; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Sangree AK; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Szegletes Z; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Griffith A; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Feeley MN; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Sanson KR; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA., Baidi Y; Cancer Program, Broad Institute, Cambridge, MA 02142, USA., Koblan LW; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Neal JT; Cancer Program, Broad Institute, Cambridge, MA 02142, USA., Doench JG; Genetic Perturbation Platform, Broad Institute, Cambridge, MA 02142, USA. Electronic address: jdoench@broadinstitute.org.

Publikováno v: Cell [Cell] 2021 Feb 18; Vol. 184 (4), pp. 1064-1080.e20.

Golgi α1,2-mannosidase I induces clustering and compartmentalization of CD147 during epithelial cell migration.

Autor: Gonzalez-Andrades M; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Jalimarada SS; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Rodriguez-Benavente M; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Feeley MN; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Woodward AM; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., AbuSamra DB; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Argüeso P; Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Publikováno v: Cell adhesion & migration [Cell Adh Migr] 2020 Dec; Vol. 14 (1), pp. 96-105.