Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification

Autor: Muge Qile, Yuan Ji, Marien J. C. Houtman, Marlieke Veldhuis, Fee Romunde, Bart Kok, Marcel A. G. van der Heyden

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

KIR2.1 potassium channels, producing inward rectifier potassium current (IK1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. Abnormal KIR2.1 function, either de

Externí odkaz: https://doaj.org/article/4879b9edd99e4745970180a8414bb651

LUF7244 plus Dofetilide Rescues Aberrant K

Autor: Muge, Qile, Yuan, Ji, Tyona D, Golden, Marien J C, Houtman, Fee, Romunde, Doreth, Fransen, Willem B, van Ham, Ad P, IJzerman, Craig T, January, Laura H, Heitman, Anna, Stary-Weinzinger, Brian P, Delisle, Marcel A G, van der Heyden

Publikováno v: Molecular pharmacology. 97(6)

Voltage-gated potassium 11.1 (K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01db1ff9fcbe03994a1caab0d28eec83
https://pubmed.ncbi.nlm.nih.gov/32241959

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Autor: Yuan Ji, Marien J C Houtman, Gijs van Haaften, Jantien Zandvoort, Karen Duran, Marcel A.G. van der Heyden, Hiroki Takanari, Eva-Maria Zangerl-Plessl, Fee Romunde, Anna Stary-Weinzinger, Marlieke G. Veldhuis

Publikováno v: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-10 (2017)
Journal of Biomedical Science
Journal of Biomedical Science, 24(1). BioMed Central

Background The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased IK1, short Q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78706751446ca0cd4e20d015ddfc35e
https://doi.org/10.1186/s12929-017-0352-x