Zobrazeno 1 - 10 of 152 pro vyhledávání: '"Fedoruk-Wyszomirska A"'
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Akademický článek
Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines
Autor: Sebastian Rykowski, Dorota Gurda-Woźna, Agnieszka Fedoruk-Wyszomirska, Marta Orlicka-Płocka, Aleksandra Kowalczyk, Paweł Stączek, Marta Denel-Bobrowska, Katarzyna Biniek-Antosiak, Wojciech Rypniewski, Eliza Wyszko, Agnieszka B. Olejniczak
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesi
Externí odkaz: https://doaj.org/article/da14e44f868943c69fa7db724c26232b
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4
Akademický článek
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5
Akademický článek
Antiaging Effect of 4-N-Furfurylcytosine in Yeast Model Manifests through Enhancement of Mitochondrial Activity and ROS Reduction
Autor: Paweł Pawelczak, Agnieszka Fedoruk-Wyszomirska, Eliza Wyszko
Publikováno v: Antioxidants, Vol 11, Iss 5, p 850 (2022)
Small compounds are a large group of chemicals characterized by various biological properties. Some of them also have antiaging potential, which is mainly attributed to their antioxidant activity. In this study, we examined the antiaging effect of 4-
Externí odkaz: https://doaj.org/article/0685f2893aac43c99060102bf151f23d
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6
Akademický článek
Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment.
Autor: Dariusz Wawrzyniak, Małgorzata Grabowska, Paweł Głodowicz, Konrad Kuczyński, Bogna Kuczyńska, Agnieszka Fedoruk-Wyszomirska, Katarzyna Rolle
Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237889 (2020)
Tenascin-C (TNC) is an extracellular matrix (ECM) glycoprotein that plays an important role in cell proliferation, migration, and tumour invasion in various cancers. TNC is one of the main protein overexpressed in breast cancer, indicating a role for
Externí odkaz: https://doaj.org/article/695f49d0122c4e86960e9e866e69bffb
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7
Akademický článek
Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives
Autor: Marta Orlicka-Płocka, Agnieszka Fedoruk-Wyszomirska, Dorota Gurda-Woźna, Paweł Pawelczak, Patrycja Krawczyk, Małgorzata Giel-Pietraszuk, Grzegorz Framski, Tomasz Ostrowski, Eliza Wyszko
Publikováno v: Antioxidants, Vol 10, Iss 6, p 950 (2021)
Recently, small compound-based therapies have provided new insights into the treatment of glioblastoma multiforme (GBM) by inducing oxidative impairment. Kinetin riboside (KR) and newly designed derivatives (8-azaKR, 7-deazaKR) selectively affect the
Externí odkaz: https://doaj.org/article/83db956acc3f42ef83ec6d3716681449
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9
Design of DNA Intercalators Based on 4-Carboranyl-1,8-Naphthalimides: Investigation of Their DNA-Binding Ability and Anticancer Activity
Autor: Sebastian Rykowski, Dorota Gurda-Woźna, Marta Orlicka-Płocka, Agnieszka Fedoruk-Wyszomirska, Małgorzata Giel-Pietraszuk, Eliza Wyszko, Aleksandra Kowalczyk, Paweł Stączek, Katarzyna Biniek-Antosiak, Wojciech Rypniewski, Agnieszka B. Olejniczak
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4598
In the present study, we continue our work related to the synthesis of 1,8-naphthalimide and carborane conjugates and the investigation of their anticancer activity and DNA-binding ability. For this purpose, a series of 4-carboranyl-1,8-naphthalimide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f14cbc7daad357a401a53c6b7c1bc47
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