Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Fedor Denkers"'
Autor:
Noortje van Gils, Han J.M.P. Verhagen, Michaël Broux, Tania Martiáñez, Fedor Denkers, Eline Vermue, Arjo Rutten, Tamás Csikós, Sofie Demeyer, Meryem Çil, Marjon Al, Jan Cools, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Renee X. Menezes, Linda Smit
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105013- (2022)
Summary: Although chemotherapy induces complete remission in the majority of acute myeloid leukemia (AML) patients, many face a relapse. This relapse is caused by survival of chemotherapy-resistant leukemia (stem) cells (measurable residual disease;
Externí odkaz:
https://doaj.org/article/84ab3dd633704ce3b8af11a7a4647841
Autor:
Noortje van Gils, Tania Martiañez Canales, Eline Vermue, Arjo Rutten, Fedor Denkers, Tiem van der Deure, Gert J. Ossenkoppele, Francis Giles, Linda Smit
Publikováno v:
HemaSphere, Vol 5, Iss 8, p e610 (2021)
Acute myeloid leukemia (AML) is a disease characterized by transcriptional dysregulation that results in a block in differentiation and aberrant self-renewal. Inhibitors directed to epigenetic modifiers, aiming at transcriptional reprogramming of AML
Externí odkaz:
https://doaj.org/article/3fb817b7e6284c9b96430bb8fba91701
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this treatment induces complete remissions in the majority of patients, man
Externí odkaz:
https://doaj.org/article/333ccf2ebb7043798d01b31a53078e9a
Autor:
Han J.M.P. Verhagen, Noortje van Gils, Tania Martiañez, Anna van Rhenen, Arjo Rutten, Fedor Denkers, David C. de Leeuw, Marjon A. Smit, Mei-Ling Tsui, Louise L.E. de Vos Klootwijk, Renee X. Menezes, Meyram Çil, Margaretha G.M. Roemer, Eline Vermue, Stan Heukelom, Sonja Zweegman, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Linda Smit
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3021-3035.e5 (2018)
Summary: Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic st
Externí odkaz:
https://doaj.org/article/786323a84cf84b2ca5db63b64d5ff6a0
Autor:
Jeroen J.W.M. Janssen, Fedor Denkers, Peter Valk, Jan J. Cornelissen, Gerrit-Jan Schuurhuis, Gert J. Ossenkoppele
Publikováno v:
Haematologica, Vol 95, Iss 6 (2010)
Externí odkaz:
https://doaj.org/article/5888564d138f4b8188e7fb11242a0d45
Autor:
Corine J. Hess, Nicole Feller, Fedor Denkers, Angèle Kelder, Pauline A. Merle, Michael C. Heinrich, Amy Harlow, Johannes Berkhof, Gert J. Ossenkoppele, Quinten Waisfisz, Gerrit J. Schuurhuis
Publikováno v:
Haematologica, Vol 94, Iss 1 (2009)
Background About 70–80 percent of patients with acute myeloid leukemia enter complete remission, but at least half of these patients who achieve remission go on to relapse. Improved treatment is likely to come from increasing the time to relapse, e
Externí odkaz:
https://doaj.org/article/000a5dbd77e8473c871c7c8c45cc02f0
Autor:
Linda Smit, Arjan A. van de Loosdrecht, Gert J. Ossenkoppele, Theresia M. Westers, Renée X. de Menezes, Fedor Denkers, Willemijn van den Ancker, David C. de Leeuw
PDF file - 100K, Supplementary Table 1: Literature based signature; Supplemental Table 2: Flow cytometric and genetic characteristics of the patients with leukemia of ambiguous lineage; Supplementary Table 3: Significantly discriminative microRNAs be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41616593ed0de997aa8e9b2dd482b0c2
https://doi.org/10.1158/1078-0432.22452528.v1
https://doi.org/10.1158/1078-0432.22452528.v1
Autor:
Linda Smit, Arjan A. van de Loosdrecht, Gert J. Ossenkoppele, Theresia M. Westers, Renée X. de Menezes, Fedor Denkers, Willemijn van den Ancker, David C. de Leeuw
PDF file - 49K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63598f0583434bdb2a2a4e01bc379385
https://doi.org/10.1158/1078-0432.22452531.v1
https://doi.org/10.1158/1078-0432.22452531.v1
Autor:
Linda Smit, Arjan A. van de Loosdrecht, Gert J. Ossenkoppele, Theresia M. Westers, Renée X. de Menezes, Fedor Denkers, Willemijn van den Ancker, David C. de Leeuw
Purpose: Classification of acute leukemia is based on the commitment of leukemic cells to the myeloid or the lymphoid lineage. However, a small percentage of acute leukemia cases lack straightforward immunophenotypical lineage commitment. These leuke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0807955d07fb8c255ba41364eeecb4b3
https://doi.org/10.1158/1078-0432.c.6522504.v1
https://doi.org/10.1158/1078-0432.c.6522504.v1
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 54KB, Genes correlated with microRNA-126 expression in 163 AML patients show overlap with stem cell genes: Genes positively and negatively associated with miR-126 expression in 163 AML patients as published by (34). 854 genes were signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be0071c09a534453e4a690227defec8
https://doi.org/10.1158/0008-5472.22400873
https://doi.org/10.1158/0008-5472.22400873