Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants.

Autor: Mkrtchyan L; Molecular Neuroscience Group, Institute of Molecular Biology, Yerevan 0014, Armenia., Sahakyan H; Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology, Yerevan 0014, Armenia., Eldstrom J; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Karapetyan T; Molecular Neuroscience Group, Institute of Molecular Biology, Yerevan 0014, Armenia., Abrahamyan A; Molecular Neuroscience Group, Institute of Molecular Biology, Yerevan 0014, Armenia., Nazaryan K; Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology, Yerevan 0014, Armenia., Schwarz JR; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany., Kneussel M; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany., Fedida D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Vardanyan V; Molecular Neuroscience Group, Institute of Molecular Biology, Yerevan 0014, Armenia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 17; Vol. 121 (51), pp. e2411182121. Date of Electronic Publication: 2024 Dec 13.

Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors.

Autor: Fedida D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Sastre D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Dou Y; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Westhoff M; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Eldstrom J; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2024 Mar 04; Vol. 156 (3). Date of Electronic Publication: 2024 Jan 31.

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K ⁺ channel.

Autor: Chen IS; Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan.; Department of Pharmacology, School of Medicine, Wakayama Medical University, Wakayama, Japan., Eldstrom J; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada., Fedida D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada., Kubo Y; Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan.

Publikováno v: The Journal of physiology [J Physiol] 2022 Feb; Vol. 600 (3), pp. 603-622. Date of Electronic Publication: 2021 Dec 29.

Mechanisms Underlying the Shortening of the Action Potential at High and Low Stimulus Rates in Sheep Purkinje Fibres

Autor: Fedida, D., Boyett, M. R.

Publikováno v: Proceedings of the Royal Society of London. Series B, Biological Sciences, 1985 Oct . 225(1241), 481-502.

Externí odkaz: https://www.jstor.org/stable/35916

Mechanism of external K+ sensitivity of KCNQ1 channels.

Autor: Abrahamyan A; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Eldstrom J; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia , Vancouver, BC, Canada., Sahakyan H; Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Karagulyan N; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Mkrtchyan L; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Karapetyan T; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Sargsyan E; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Kneussel M; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg , Hamburg, Germany., Nazaryan K; Laboratory of Computational Modeling of Biological Processes, Institute of Molecular Biology of National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia., Schwarz JR; Institute for Molecular Neurogenetics, Center for Molecular Neurobiology Hamburg , Hamburg, Germany., Fedida D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia , Vancouver, BC, Canada., Vardanyan V; Molecular Neuroscience Group, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia , Yerevan, Armenia.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2023 May 01; Vol. 155 (5). Date of Electronic Publication: 2023 Feb 21.