Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Fedichev P"'
Publikováno v:
Sci. Rep. 13, 8250 (2023)
Deep generative chemistry models emerge as powerful tools to expedite drug discovery. However, the immense size and complexity of the structural space of all possible drug-like molecules pose significant obstacles, which could be overcome with hybrid
Externí odkaz:
http://arxiv.org/abs/2108.11644
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Deep generative chemistry models emerge as powerful tools to expedite drug discovery. However, the immense size and complexity of the structural space of all possible drug-like molecules pose significant obstacles, which could be overcome wi
Externí odkaz:
https://doaj.org/article/bab6a3d32ef74fd486f40f9d0ba21a32
Autor:
Konstantin Avchaciov, Marina P. Antoch, Ekaterina L. Andrianova, Andrei E. Tarkhov, Leonid I. Menshikov, Olga Burmistrova, Andrei V. Gudkov, Peter O. Fedichev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Biomarkers of age and frailty may aid in understanding the aging process, predicting lifespan or health span and in assessing the effects of anti-aging interventions. Here, the authors show that combining physics-based models and deep learning may en
Externí odkaz:
https://doaj.org/article/0fb500c105a24e0387e605b7b51feb68
Akademický článek
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We compiled a demo application and collected a motion database of more than 10,000 smartphone users to produce a health risk model trained on physical activity streams. We turned to adversarial domain adaptation and employed the UK Biobank dataset of
Externí odkaz:
http://arxiv.org/abs/1812.02522
Autor:
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolaños
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage disease typically with childhood onset of neurodegenerative symptoms. Here the authors report that in a mouse model of CLN7 disease neuronal reactive oxygen species and the activit
Externí odkaz:
https://doaj.org/article/3a651b3190b84e729467d309cc661713
Autor:
Kejun Ying, Ranran Zhai, Timothy V. Pyrkov, Anastasia V. Shindyapina, Marco Mariotti, Peter O. Fedichev, Xia Shen, Vadim N. Gladyshev
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-15 (2021)
Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospi
Externí odkaz:
https://doaj.org/article/9432b47b0f474ab28368a68b3468e756
Autor:
Podolskiy, D., Molodtcov, I., Zenin, A., Kogan, V., Menshikov, L. I., Gladyshev, Vadim N., Reis, Robert J. Shmookler, Fedichev, P. O.
Although accumulation of molecular damage is suggested to be an important molecular mechanism of aging, a quantitative link between the dynamics of damage accumulation and mortality of species has so far remained elusive. To address this question, we
Externí odkaz:
http://arxiv.org/abs/1502.04307
Autor:
Timothy V. Pyrkov, Konstantin Avchaciov, Andrei E. Tarkhov, Leonid I. Menshikov, Andrei V. Gudkov, Peter O. Fedichev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Aging is associated with an increased risk of chronic diseases and functional decline. Here, the authors investigate the fluctuations of physiological indices along aging trajectories and observed a characteristic decrease in the organism state recov
Externí odkaz:
https://doaj.org/article/48de15a8f1014ada8274110622c45562
Akademický článek
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