Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.

Autor: Larose H; Department of Pathology, University of Cambridge, Cambridge, UK., Prokoph N; Department of Pathology, University of Cambridge, Cambridge, UK., Matthews JD; Department of Pathology, University of Cambridge, Cambridge, UK., Schlederer M; Department of Pathology, Medical University of Vienna, Vienna, Austria., Högler S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria., Alsulami AF; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK., Ducray SP; Department of Pathology, University of Cambridge, Cambridge, UK., Nuglozeh E; Colleges of Medicine and Applied Medical Sciences, University of Haill, Haill, Saudi Arabia., Fazaludeen FMS; A.I Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland., Elmouna A; Colleges of Medicine and Applied Medical Sciences, University of Hail, Hail, Saudi Arabia., Ceccon M; University of Milano-Bicocca, Monza, Italy., Mologni L; University of Milano-Bicocca, Monza, Italy., Gambacorti-Passerini C; University of Milano-Bicocca, Monza, Italy., Hoefler G; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Lobello C; Center of Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Pospisilova S; Department of Internal Medicine Hematology and Oncology, University Hospital Brno, Czech Republic., Janikova A; Department of Internal Medicine Hematology and Oncology, University Hospital Brno, Czech Republic., Woessmann W; University Hospital Hamburg-Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany., Damm-Welk C; University Hospital Hamburg-Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany., Zimmermann M; Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany., Federova A; Belarusian Centre for Paediatric Oncology, Hematology and Immunology, Minsk, Belarus., Malone A; Our Lady Children Hospital, Crumlin, Ireland., Smith O; Our Lady Children Hospital, Crumlin, Ireland., Wasik M; Perelman School of Medicine, Philadelphia, USA., Inghirami G; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY USA., Lamant L; Institut Universitaire du Cancer Toulouse, Oncopole et Université Paul-Sabatier, Toulouse, France., Blundell TL; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK., Klapper W; Department of Pathology, Hematopathology Section, UKSH Campus Kiel, Kiel, Germany., Merkel O; Department of Pathology, Medical University of Vienna, Vienna, Austria., Burke AGA; Department of Paediatric Oncology, Addenbrooke Hospital, Cambridge, UK., Mian S; Colleges of Medicine and Applied Medical Sciences, University of Hail, Hail, Saudi Arabia., Ashankyty I; College of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Kenner L; Medical University of Vienna and Ludwig-Boltzmann Institute for Cancer Research, Vienna, Austria., Turner SD; Department of Pathology, University of Cambridge, Cambridge, UK.

Publikováno v: Haematologica [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1693-1704. Date of Electronic Publication: 2021 Jun 01.