Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Federico Taverna"'
Autor:
Pauline de Zeeuw, Lucas Treps, Melissa García-Caballero, Ulrike Harjes, Joanna Kalucka, Carla De Legher, Katleen Brepoels, Kristel Peeters, Stefan Vinckier, Joris Souffreau, Ann Bouché, Federico Taverna, Jonas Dehairs, Ali Talebi, Bart Ghesquière, Johan Swinnen, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Peter Carmeliet
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Endothelial cells (ECs) are highly glycolytic, but whether they generate glycolytic intermediates via gluconeogenesis (GNG) in glucose-deprived conditions remains unknown. Here, we report that glucose-deprived ECs upregulate the GNG enzyme P
Externí odkaz:
https://doaj.org/article/8030d02175c3406794109c5a78ebe4dd
Autor:
Vincent Geldhof, Laura P. M. H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li, Yonglun Luo, Peter Carmeliet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Tumor blood vessels contribute to cancer growth, invasion and metastasis. Here, by using single cell transcriptomics, the authors report an inventory of endothelial cell heterogeneity in patients with breast cancer, including a subtype that expresses
Externí odkaz:
https://doaj.org/article/f607566042124ddc85658b5b9cc9abac
Autor:
Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109253- (2021)
Summary: Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing vi
Externí odkaz:
https://doaj.org/article/7dadc23d237d4576aa0fd412a6c1555b
Autor:
Sonja Loges, Peter Carmeliet, Johannes Roth, Thomas Vogl, Carsten Bokemeyer, Klaus Pantel, Johanna M. Brandner, Stefan Vinckier, Sarina Päsler, Victoria Gensch, Meike Kuhlencord, Federico Taverna, Ines Miranda Santos, Isabel Ben-Batalla, Mark Wroblewski, Florian Udonta, Raimund Bauer
Intrinsic and adaptive resistance hampers the success of antiangiogenic therapies (AAT), especially in breast cancer where this treatment modality has proven largely ineffective. Therefore, novel strategies to improve the efficacy of AAT are warrante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a7abedc61c2254f2b5e1af410c6bc3
https://doi.org/10.1158/0008-5472.c.6510117
https://doi.org/10.1158/0008-5472.c.6510117
Autor:
Saran Kumar, Libat Bar-Lev, Husni Sharife, Myriam Grunewald, Maxim Mogilevsky, Tamar Licht, Jermaine Goveia, Federico Taverna, Iddo Paldor, Peter Carmeliet, Eli Keshet
Publikováno v:
Kumar, S, Bar-Lev, L, Sharife, H, Grunewald, M, Mogilevsky, M, Licht, T, Goveia, J, Taverna, F, Paldor, I, Carmeliet, P & Keshet, E 2022, ' Identification of vascular cues contributing to cancer cell stemness and function ', Angiogenesis . https://doi.org/10.1007/s10456-022-09830-z
Glioblastoma stem cells (GSCs) reside close to blood vessels (BVs) but vascular cues contributing to GSC stemness and the nature of GSC-BVs cross talk are not fully understood. Here, we dissected vascular cues influencing GSC gene expression and func
Serial RNA-seq studies of bulk samples are widespread and provide an opportunity for improved understanding of gene regulation during e.g., development or response to an incremental dose of a pharmacotherapeutic. In addition, the widely popular singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0043674085cbd519a74e8ec640443db4
https://doi.org/10.1101/2022.02.18.481000
https://doi.org/10.1101/2022.02.18.481000
Autor:
Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort
Publikováno v:
Teuwen, L-A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L-C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, pp. 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec69ffb517f91c2c67be4491da86f10
https://lirias.kuleuven.be/handle/123456789/676947
https://lirias.kuleuven.be/handle/123456789/676947
Autor:
Vincent Geldhof, Laura P. M. H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li, Yonglun Luo, Peter Carmeliet
Publikováno v:
Geldhof, V, de Rooij, L P M H, Sokol, L, Amersfoort, J, De Schepper, M, Rohlenova, K, Hoste, G, Vanderstichele, A, Delsupehe, A-M, Isnaldi, E, Dai, N, Taverna, F, Khan, S, Truong, A-C K, Teuwen, L-A, Richard, F, Treps, L, Smeets, A, Nevelsteen, I, Weynand, B, Vinckier, S, Schoonjans, L, Kalucka, J, Desmedt, C, Neven, P, Mazzone, M, Floris, G, Punie, K, Dewerchin, M, Eelen, G, Wildiers, H, Li, X, Luo, Y & Carmeliet, P 2022, ' Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast ', Nature Communications, vol. 13, no. 1, pp. 5511 . https://doi.org/10.1038/s41467-022-33052-y
Nature communications
Geldhof, V, de Rooij, L P M H, Sokol, L, Amersfoort, J, De Schepper, M, Rohlenova, K, Hoste, G, Vanderstichele, A, Delsupehe, A M, Isnaldi, E, Dai, N, Taverna, F, Khan, S, Truong, A C K, Teuwen, L A, Richard, F, Treps, L, Smeets, A, Nevelsteen, I, Weynand, B, Vinckier, S, Schoonjans, L, Kalucka, J, Desmedt, C, Neven, P, Mazzone, M, Floris, G, Punie, K, Dewerchin, M, Eelen, G, Wildiers, H, Li, X, Luo, Y & Carmeliet, P 2022, ' Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast ', Nature Communications, vol. 13, 5511 . https://doi.org/10.1038/s41467-022-33052-y
Nature communications
Geldhof, V, de Rooij, L P M H, Sokol, L, Amersfoort, J, De Schepper, M, Rohlenova, K, Hoste, G, Vanderstichele, A, Delsupehe, A M, Isnaldi, E, Dai, N, Taverna, F, Khan, S, Truong, A C K, Teuwen, L A, Richard, F, Treps, L, Smeets, A, Nevelsteen, I, Weynand, B, Vinckier, S, Schoonjans, L, Kalucka, J, Desmedt, C, Neven, P, Mazzone, M, Floris, G, Punie, K, Dewerchin, M, Eelen, G, Wildiers, H, Li, X, Luo, Y & Carmeliet, P 2022, ' Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast ', Nature Communications, vol. 13, 5511 . https://doi.org/10.1038/s41467-022-33052-y
Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) from 9 BC patients and compare them to published EC taxonomies from lu
Autor:
Peter Carmeliet, Laure-Anne Teuwen, Lin Lin, Luc Schoonjans, Guy Eelen, Rongyuan Chen, Carla De Legher, Tobias K. Karakach, Sébastien J. Dumas, Weisi Lu, Joanna Kalucka, Elda Meta, Lars Bolund, Nadine V. Conchinha, Mieke Dewerchin, Stefan Vinckier, Kim D. Falkenberg, Katerina Rohlenova, Federico Taverna, Yonglun Luo, Xuri Li, Jermaine Goveia, Laura P.M.H. de Rooij, Shawez Khan, Ton J. Rabelink, Magdalena Parys, Mila Borri
Publikováno v:
J Am Soc Nephrol
Journal of the American Society of Nephrology
Dumas, S J, Meta, E, Borri, M, Goveia, J, Rohlenova, K, Conchinha, N V, Falkenberg, K, Teuwen, L-A, de Rooij, L, Kalucka, J, Chen, R, Khan, S, Taverna, F, Lu, W, Parys, M, De Legher, C, Vinckier, S, Karakach, T K, Schoonjans, L, Lin, L, Bolund, L, Dewerchin, M, Eelen, G, Rabelink, T J, Li, X, Luo, Y & Carmeliet, P 2020, ' Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation ', Journal of the American Society of Nephrology : JASN, vol. 31, no. 1, pp. 118-138 . https://doi.org/10.1681/ASN.2019080832
Journal of the American Society of Nephrology, 31(1), 118-138. AMER SOC NEPHROLOGY
Journal of the American Society of Nephrology
Dumas, S J, Meta, E, Borri, M, Goveia, J, Rohlenova, K, Conchinha, N V, Falkenberg, K, Teuwen, L-A, de Rooij, L, Kalucka, J, Chen, R, Khan, S, Taverna, F, Lu, W, Parys, M, De Legher, C, Vinckier, S, Karakach, T K, Schoonjans, L, Lin, L, Bolund, L, Dewerchin, M, Eelen, G, Rabelink, T J, Li, X, Luo, Y & Carmeliet, P 2020, ' Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation ', Journal of the American Society of Nephrology : JASN, vol. 31, no. 1, pp. 118-138 . https://doi.org/10.1681/ASN.2019080832
Journal of the American Society of Nephrology, 31(1), 118-138. AMER SOC NEPHROLOGY
BACKGROUND: Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions and support specific kidney processes. However, the heterogeneous phenotypes of these cells remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0e38fe50f3082bab431c22dbafebb4
https://doi.org/10.1681/asn.2019080832
https://doi.org/10.1681/asn.2019080832
Autor:
Federico Taverna, Peter Carmeliet, Jermaine Goveia, Tobias K. Karakach, Luc Schoonjans, Shawez Khan, Katerina Rohlenova, Lucas Treps, Guy Eelen, Abhishek Subramanian, Mieke Dewerchin
Publikováno v:
Nucleic Acids Research
The amount of biological data, generated with (single cell) omics technologies, is rapidly increasing, thereby exacerbating bottlenecks in the data analysis and interpretation of omics experiments. Data mining platforms that facilitate non-bioinforma