Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Federico Riu"'
Autor:
Federico Riu, Roberta Ibba, Stefano Zoroddu, Simona Sestito, Michele Lai, Sandra Piras, Luca Sanna, Valentina Bordoni, Luigi Bagella, Antonio Carta
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2223-2240 (2022)
Introduction: Colchicine-binding site inhibitors are some of the most interesting ligands belonging to the wider family of microtubule-destabilising agents.Results: A novel series of 4′-fluoro-substituted ligands (5–13) was synthesised. The antip
Externí odkaz:
https://doaj.org/article/3146be1fa5764644947125552e4d52ee
Autor:
Roberta Ibba, Paola Corona, Francesca Nonne, Paola Caria, Gabriele Serreli, Vanessa Palmas, Federico Riu, Simona Sestito, Maria Nieddu, Roberta Loddo, Giuseppina Sanna, Sandra Piras, Antonio Carta
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 429 (2023)
Several human diseases are caused by enteroviruses and are currently clinically untreatable, pushing the research to identify new antivirals. A notable number of benzo[d][1,2,3]triazol-1(2)-yl derivatives were designed, synthesized, and in vitro eval
Externí odkaz:
https://doaj.org/article/4176f5897e514b6d9e9884b6427fb6e4
Autor:
Roberta Ibba, Sandra Piras, Paola Corona, Federico Riu, Roberta Loddo, Ilenia Delogu, Gabriella Collu, Giuseppina Sanna, Paola Caria, Tinuccia Dettori, Antonio Carta
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Cancer and viral infections continue to threaten humankind causing death worldwide. Hence, the discovery of new anticancer and antiviral agents still represents a major scientific goal. Heterocycles designed to mimic the chemical structure of natural
Externí odkaz:
https://doaj.org/article/1c34b05ad681411ebcc9af6fdafc9362
Autor:
Federico Riu, Alessandro Ruda, Roberta Ibba, Simona Sestito, Ilenia Lupinu, Sandra Piras, Göran Widmalm, Antonio Carta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 942 (2022)
Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structu
Externí odkaz:
https://doaj.org/article/f8dc503de5c04460bc330b27994a5d89
Autor:
Roberta Ibba, Federico Riu, Ilenia Delogu, Ilenia Lupinu, Gavino Carboni, Roberta Loddo, Sandra Piras, Antonio Carta
Publikováno v:
Viruses, Vol 14, Iss 6, p 1300 (2022)
Bovine viral diarrhea virus (BVDV), also known as Pestivirus A, causes severe infection mostly in cattle, but also in pigs, sheep and goats, causing huge economical losses on agricultural farms every year. The infections are actually controlled by is
Externí odkaz:
https://doaj.org/article/d82c8af5d33e4403910fe908c511f7cd
Autor:
Federico Riu, Alessandro Ruda, Olof Engström, Claudio Muheim, Hani Mobarak, Jonas Ståhle, Paul Kosma, Antonio Carta, Daniel O. Daley, Göran Widmalm
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 209 (2022)
Glucosyl transferase I (WaaG) in E. coli catalyzes the transfer of an α-d-glucosyl group to the inner core of the lipopolysaccharide (LPS) and plays an important role in the biogenesis of the outer membrane. If its activity could be inhibited, the i
Externí odkaz:
https://doaj.org/article/cd1f7434b9224174af3b332aa26cca7c
Autor:
Silvia Madeddu, Roberta Ibba, Giuseppina Sanna, Sandra Piras, Federico Riu, Alessandra Marongiu, Annalisa Ambrosino, Paola Caria, Valentina Onnis, Gianluigi Franci, Aldo Manzin, Antonio Carta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 181 (2022)
The Enterovirus genus includes many viruses that are pathogenic in humans, including Coxsackie viruses and rhinoviruses, as well as the emerging enteroviruses D68 and A71. Currently, effective antiviral agents are not available for the treatment or p
Externí odkaz:
https://doaj.org/article/11c82f42b7644c9699bdeac5749e379e
Autor:
Widmalm, Federico Riu, Alessandro Ruda, Olof Engström, Claudio Muheim, Hani Mobarak, Jonas Ståhle, Paul Kosma, Antonio Carta, Daniel O. Daley, Göran
Publikováno v:
Pharmaceuticals; Volume 15; Issue 2; Pages: 209
Glucosyl transferase I (WaaG) in E. coli catalyzes the transfer of an α-d-glucosyl group to the inner core of the lipopolysaccharide (LPS) and plays an important role in the biogenesis of the outer membrane. If its activity could be inhibited, the i
Autor:
Federico Riu, Roberta Loddo, Silvia Madeddu, Ilenia Delogu, Paola Corona, Antonio Carta, Giuseppina Sanna, Roberta Ibba, Sandra Piras, Gabriele Murineddu
Publikováno v:
The Open Medicinal Chemistry Journal. 14:83-98
Background: For the last thirty years, the benzotriazole scaffold has been the object of our group interest and we have already presented some results on the antiviral activity of our compounds. Objective: In this article, we conclude the exploration
Autor:
Roberta Ibba, Valentina Bordoni, Luigi Bagella, Simona Sestito, Michele Lai, Sanna L, M. Andrea Scorciapino, Federico Riu, Antonio Carta, Sandra Piras
Publikováno v:
European journal of medicinal chemistry. 222
Microtubules (MTs) are the principal target for drugs acting against mitosis. These compounds, called microtubule targeting agents (MTAs), cause a mitotic arrest during G2/M phase, subsequently inducing cell apoptosis. MTAs could be classified in two