Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Federico Probst"'
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Akademický článek
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
Autor: Matthias Brendel, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern-Sternberg, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Igor Yakushev, Paul Cumming, Guido Boening, Sibylle Ziegler, Jochen Herms, Armin Giese, Axel Rominger
Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Augmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau deposition. However, there has been no test of this concept in animal models of Alzheimer’s
Externí odkaz: https://doaj.org/article/3b973999c8e94cd6996a2a71167a7056
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2
Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
Autor: Michael Willem, Tanja Blume, Bernd Bohrmann, Peter Bartenstein, Matthias Brendel, Axel Rominger, Christian Haass, Franz-Josef Gildehaus, Federico Probst, Anna Jaworska, Felix Overhoff, Jochen Herms
Publikováno v: Theranostics 8(18), 4957-4968 (2018). doi:10.7150/thno.27868
Brendel, Matthias; Jaworska, Anna; Overhoff, Felix; Blume, Tanja; Probst, Federico; Gildehaus, Franz-Josef; Bartenstein, Peter; Haass, Christian; Bohrmann, Bernd; Herms, Jochen; Willem, Michael; Rominger, Axel (2018). Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics, 8(18), pp. 4957-4968. Ivyspring International 10.7150/thno.27868
Theranostics
Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [18F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8d9702dd54d356f06da024b7bdae3
https://doi.org/10.7150/thno.27868
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3
Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study
Autor: Jochen Herms, Nathalie L. Albert, Federico Probst, Maximilian Deussing, Barbara von Ungern-Sternberg, Tanja Blume, Carola Focke, Peter Bartenstein, Felix Overhoff, Simon Lindner, Finn Peters, Matthias Brendel, Christian Haass, Axel Rominger, Gernot Kleinberger, Anna Jaworska
Publikováno v: Journal of nuclear medicine 58(12), 1984-1990 (2017). doi:10.2967/jnumed.117.195107
Contrary to findings in the human brain, 18F-FDG PET shows cerebral hypermetabolism of aged wild-type (WT) mice relative to younger animals, supposedly due to microglial activation. Therefore, we used dual-tracer small-animal PET to examine directly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8f291b0d6d28eb7927914164fc10b8
https://doi.org/10.2967/jnumed.117.195107
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4
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau
Autor: Maximilian Deussing, Matthias Brendel, Paul Cumming, Guido Boening, Finn Peters, Felix Overhoff, Christian Griesinger, Igor Yakushev, Sergey Ryazanov, Johannes Levin, Andreas Zwergal, Andrei Leonov, Barbara von Ungern-Sternberg, Jochen Herms, Lena Kaiser, Armin Giese, Tanja Blume, Peter Bartenstein, Federico Probst, Sibylle Ziegler, Axel Rominger
Publikováno v: Alzheimer's Research and Therapy
Alzheimer's research & therapy 11(1), 67 (2019). doi:10.1186/s13195-019-0522-z
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Alzheimer's Research & Therapy
Brendel, Matthias; Deussing, Maximilian; Blume, Tanja; Kaiser, Lena; Probst, Federico; Overhoff, Felix; Peters, Finn; von Ungern-Sternberg, Barbara; Ryazanov, Sergey; Leonov, Andrei; Griesinger, Christian; Zwergal, Andreas; Levin, Johannes; Bartenstein, Peter; Yakushev, Igor; Cumming, Paul; Boening, Guido; Ziegler, Sibylle; Herms, Jochen; Giese, Armin; ... (2019). Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau. Alzheimer's research & therapy, 11(1), p. 67. BioMed Central 10.1186/s13195-019-0522-z
Background Augmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau deposition. However, there has been no test of this concept in animal models of Alzheimer’s disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a0d8cb3235209b5f107672bb8426cf
https://zenodo.org/record/3360079
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6
Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models
Autor: Viktoria Korzhova, Matthias Brendel, Christian Haass, Ryuichi Harada, Yukitsuka Kudo, Federico Probst, Nobuyuki Okamura, Fred Van Leuven, Peter Bartenstein, Felix Overhoff, Jochen Herms, Simon Lindner, Axel Rominger, Janette Carlsen, Anna Jaworska
Publikováno v: Journal of nuclear medicine 57(5), 792-798 (2016). doi:10.2967/jnumed.115.163493
Abnormal accumulation of tau aggregates in the brain is one of the hallmarks of Alzheimer disease neuropathology. We visualized tau deposition in vivo with the previously developed 2-arylquinoline derivative (18)F-THK5117 using small-animal PET in co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed39e58f3cded9502768d1088a9c47c3
https://doi.org/10.2967/jnumed.115.163493
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7
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
Autor: Christian Haass, Laurence Ozmen, Matthias Brendel, Axel Rominger, Michael Ewers, Gernot Kleinberger, Tanja Blume, Janette Carlsen, Peter Bartenstein, Anna Jaworska, Federico Probst, Franz Josef Gildehaus, Nathalie L. Albert, Jochen Herms, Felix Overhoff, Marc Suárez-Calvet, Karlheinz Baumann, Simon Lindner
Publikováno v: Frontiers in aging neuroscience 9, 8 (2017). doi:10.3389/fnagi.2017.00008
Frontiers in Aging Neuroscience
Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been reported to significantly increase the risk of developing Alzheimer’s disease (AD). Since TREM2 is specifically expressed by microglia in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df7b3355e1cacec3c1d142b04404121
https://pub.dzne.de/record/139007
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8
Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
Autor: Christian Haass, Viktoria Korzhova, Jochen Herms, Matthias Brendel, Felix Overhoff, Andreas Delker, Franz-Josef Gildehaus, Karlheinz Baumann, Janette Carlsen, Anna Jaworska, Axel Rominger, Peter Bartenstein, Carola Focke, Federico Probst
Publikováno v: Frontiers in neuroscience 10, 45 (2016). doi:10.3389/fnins.2016.00045
Frontiers in Neuroscience
Preclinical PET studies of β-amyloid (Aβ) accumulation are of growing importance, but comparisons between research sites require standardized and optimized methods for quantitation. Therefore, we aimed to evaluate systematically the (1) impact of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d1902866d18296ccf6e7457f3fdbe6
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9
Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
Autor: Franz-Josef Gildehaus, Felix Overhoff, Karlheinz Baumann, Viktoria Korzhova, Anna Jaworska, Simon Lindner, Nathalie L. Albert, Axel Rominger, Roswitha Beck, Jochen Herms, Christian Haass, Peter Bartenstein, Federico Probst, Gernot Kleinberger, Matthias Brendel
Publikováno v: Journal of nuclear medicine 57(6), 954-960 (2016). doi:10.2967/jnumed.115.167858
Amyloid imaging by small-animal PET in models of Alzheimer disease (AD) offers the possibility to track amyloidogenesis and brain energy metabolism. Because microglial activation is thought to contribute to AD pathology, we undertook a triple-tracer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a227b884f25c31324b3fe3521c7bce2
https://pubmed.ncbi.nlm.nih.gov/26912428
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