Výsledky vyhledávání - "Federico Nicolás Penas"

Akademický článek

Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain

Autor: Ágata Carolina Cevey, Gerardo Ariel Mirkin, Federico Nicolás Penas, Nora Beatriz Goren

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 12-22 (2016)

Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) due to Nifurtimox shortage or unavailability. Both induce adverse drug effects (ADE)

Externí odkaz: https://doaj.org/article/f6160acb9828489a80ca1f8ef7aa8510

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Akademický článek

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice

Autor: Federico Nicolás Penas, Davide Carta, Ganna Dmytrenko, Gerado A. Mirkin, Carlos Pablo Modenutti, Ágata Carolina Cevey, Maria Jimena Rada, Maria Grazia Ferlin, María Elena Sales, Nora Beatriz Goren

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease. U

Externí odkaz: https://doaj.org/article/c8a224c80f7a498fa9b2d48ab0c80d9c

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Macrophages Mediate Healing Properties of Fenofibrate in Experimental Chagasic Cardiomyopathy

Autor: Ágata Carolina Cevey, Azul Victoria Pieralisi, Martín Donato, Jimena Rada, Ricardo Jorge Gelpi, Gerardo Ariel Mirkin, Nora Beatriz Goren, Federico Nicolás Penas

Publikováno v: ACS Infectious Diseases. 9:213-220

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b9cfc0fef4810ebda32351a28214c87
https://doi.org/10.1021/acsinfecdis.2c00535

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Genetic Deletion of Galectin-3 Alters the Temporal Evolution of Macrophage Infiltration and Healing Affecting the Cardiac Remodeling and Function after Myocardial Infarction in Mice

Autor: Marisa M. Fernández, Florencia Fontana Estevez, María Clara Llamosas, Ágata Carolina Cevey, Celina Morales, Eliana Cicale, Verónica Volberg, Germán E. González, Gabriela Berg, Nora Goren, Verónica Miksztowicz, Vanessa Touceda, Sofía Noli Truant, Celeste Betazza, Federico Nicolás Penas, Luciana Wilensky, Pablo Cassaglia, Nadia L. Martínez Naya

Publikováno v: The American Journal of Pathology. 2020, 190(9)
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

We studied the role of galectin-3 (Gal-3) in the expression of alternative activation markers (M2) on macrophage, cytokines, and fibrosis through the temporal evolution of healing, ventricular remodeling, and function after myocardial infarction (MI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7eb9f48ccae9c6e1d254a1f220d7a58
https://doi.org/10.1016/j.ajpath.2020.05.010

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Involvement of lipids from Leishmania braziliensis promastigotes and amastigotes in macrophage activation

Autor: Nora Goren, María Laura Belaunzarán, Ivanna Emilce Carfagna, Federico Nicolás Penas, Guadalupe Gimenez, Emanuel Bott, E.M. Lammel

Publikováno v: Molecular immunology. 125

Leishmania are obligate protozoan parasites responsible for substantial public health problems in tropical and subtropical regions around the world, with L. braziliensis being one of the causative agents of American Tegumentary Leishmaniasis. Macroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e2e0092d8f3aac5c5e3faa5f10b493
https://pubmed.ncbi.nlm.nih.gov/32659595

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P6297Genetic mutation of galectin-3 altered the temporal evolution of macrophage polarization and healing affecting the post myocardial infarct remodeling in mice

Autor: Nora Goren, Marisa M. Fernández, Luciana Wilensky, Celina Morales, F Fontana Estevez, Eliana Cicale, N L Martinez, Germán González, Ágata Carolina Cevey, Gabriela Berg, S Noli Truant, Verónica Miksztowicz, Federico Nicolás Penas, C Bettazza, Pablo Cassaglia

Publikováno v: European Heart Journal. 40

Background Myocardial infarction (MI) is a dynamic process that leads to ventricular remodeling (VR) and largely to heart failure (HF). Previous studies established that Galectin-3 (Gal-3) is highly increased in the infarct zone from the beginning of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9f7a6204944238cf1d3ed6499645f45
https://doi.org/10.1093/eurheartj/ehz746.0895

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IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole

Autor: Catalina D. Alba Soto, Ágata Carolina Cevey, Federico Nicolás Penas, Nora Goren, Gerardo A. Mirkin

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4609f45a2e5aa78a2e3ec896564276
https://www.frontiersin.org/article/10.3389/fimmu.2019.01267/full

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Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ 12,14 prostaglandin J 2

Autor: Nora Goren, Ágata Carolina Cevey, Gerardo A. Mirkin, Sofia Siffo, Federico Nicolás Penas

Publikováno v: Experimental Parasitology. 170:100-108

Trypanosoma cruzi, the etiological agent of Chagas´ disease, causes an intense inflammatory response in several tissues, including the liver. Since this organ is central to metabolism, its infection may be reflected in the outcome of the disease. 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d628eb81316bcd017ad08bee8c6a6e4
https://doi.org/10.1016/j.exppara.2016.09.015

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Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease

Autor: Nora Goren, Maria Jimena Rada, Ágata Carolina Cevey, Ricardo J. Gelpi, Martín Donato, Federico Nicolás Penas, Gerardo A. Mirkin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 378-387 (2017)

Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution of Chagas disease. Peroxis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c90da12138b5a6fb83f955bc79afd6
https://www.sciencedirect.com/science/article/pii/S2211320717300659

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