Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Federico M. Giorgi"'
Autor:
Maria Stella de Biase, Florian Massip, Tzu-Ting Wei, Federico M. Giorgi, Rory Stark, Amanda Stone, Amy Gladwell, Martin O’Reilly, Daniel Schütte, Ines de Santiago, Kerstin B. Meyer, Florian Markowetz, Bruce A. J. Ponder, Robert C. Rintoul, Roland F. Schwarz
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of tobacco smoke has long been established. More than 50% of al
Externí odkaz:
https://doaj.org/article/1477c061531644cca19787d9aa30b28b
Autor:
Nicola Balboni, Giorgia Babini, Eleonora Poeta, Michele Protti, Laura Mercolini, Maria Chiara Magnifico, Simona Nicole Barile, Francesca Massenzio, Antonella Pignataro, Federico M. Giorgi, Francesco Massimo Lasorsa, Barbara Monti
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-26 (2024)
Abstract Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate and is part of the malate–aspartate shuttle, essential for the balance of reducing equiva
Externí odkaz:
https://doaj.org/article/7790a48d279b4cc18bdc2e5d13eff545
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Daria Messelodi, Silvia Strocchi, Salvatore Nicola Bertuccio, Pascale Baden, Valentina Indio, Federico M. Giorgi, Alberto Taddia, Salvatore Serravalle, Sabrina Valente, Alessio di Fonzo, Emanuele Frattini, Roberto Bernardoni, Annalisa Pession, Daniela Grifoni, Michela Deleidi, Annalisa Astolfi, Andrea Pession
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Gaucher Disease (GD), the most common lysosomal disorder, arises from mutations in the GBA1 gene and is characterized by a wide spectrum of phenotypes, ranging from mild hematological and visceral involvement to severe neurological disease.
Externí odkaz:
https://doaj.org/article/9bd17c548d7444108e9aef7cad700e02
Autor:
Daniele Mercatelli, Elisabetta Pedace, Pierangelo Veltri, Federico M. Giorgi, Pietro Hiram Guzzi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4092-4100 (2021)
Motivation: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It has been observed that lethality seems to be related to the age of patients.
Externí odkaz:
https://doaj.org/article/305a0da52c4d42b897aeec4b359e520d
Publikováno v:
Genes, Vol 13, Iss 12, p 2240 (2022)
The molecular mechanisms and gene regulatory networks sustaining cell proliferation in neuroblastoma (NBL) cells are still not fully understood. In this tumor context, it has been proposed that anti-proliferative drugs, such as the pan-HDAC inhibitor
Externí odkaz:
https://doaj.org/article/b5852926a6584550b850c53f6a100448
Autor:
Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994- (2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://doaj.org/article/f3c43c1ed6e44cbd8f4c250a0e00921a
Autor:
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data. We apply our method to
Externí odkaz:
https://doaj.org/article/92648a09a5424a499bfc1263eb9e7330
Publikováno v:
Life, Vol 12, Iss 5, p 648 (2022)
The R programming language is approaching its 30th birthday, and in the last three decades it has achieved a prominent role in statistics, bioinformatics, and data science in general. It currently ranks among the top 10 most popular languages worldwi
Externí odkaz:
https://doaj.org/article/227c759cce6d4ebfb14ed3a998c37143
Autor:
Yu Fu, Irene Lorrai, Barry Zorman, Daniele Mercatelli, Chase Shankula, Jorge Marquez Gaytan, Celine Lefebvre, Giordano de Guglielmo, Hyunjae Ryan Kim, Pavel Sumazin, Federico M. Giorgi, Vez Repunte-Canonigo, Pietro Paolo Sanna
Publikováno v:
Viruses, Vol 14, Iss 4, p 669 (2022)
Substance use disorder is associated with accelerated disease progression in people with human immunodeficiency virus (HIV; PWH). Problem opioid use, including high-dose opioid therapy, prescription drug misuse, and opioid abuse, is high and increasi
Externí odkaz:
https://doaj.org/article/ee90c1b0e34346a5b8bb2bbfdb6a25ca