Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Federico Gómez de las Heras"'
Autor:
Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Teresa Mulet, Joaquín Rullas, Esperanza Herreros, Santiago Ferrer, Elena Jiménez, Alfonso Mendoza, Javier Regadera, Philip J Rosenthal, Ian Bathurst, David L Pompliano, Federico Gómez de las Heras, Domingo Gargallo-Viola
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2252 (2008)
To counter the global threat caused by Plasmodium falciparum malaria, new drugs and vaccines are urgently needed. However, there are no practical animal models because P. falciparum infects human erythrocytes almost exclusively. Here we describe a re
Externí odkaz:
https://doaj.org/article/1fb989ce145c431cb4b570f7cac6ad62
Autor:
Antonio Arnau, Carlos Rombolá, Juan J. Fibla, Akiko Tamura, Rafael Peñalver, José M. Mier, José Ramón Jarabo, J.J. Rivas, Guillermo Carriquiry, Félix Heras, Juan J. Rivas, Emilio Canalís, Santiago García Barajas, F. Rivas, David R. Smith, Montse Blanco, Alberto Rodríguez, Laureano Molins, Sergi Call, R. Embun, Moisés Rosenberg, Richard Wins, Javier de la Cruz, J M Hernández, Raul Embun, J. Hernández, Federico Gómez de las Heras, L. Molins, M. Carmen Marron, Esther Fernández, Jorge Freixinet, Gemma Muñoz, Beatriz de Olaiz, Diego Gonzalez-Rivas, Miguel Carbajo Carbajo, Andrés Arroyo, Javier Ruiz, M. Rubio, Sergio Bolufer, José M. García Prim, Carlos Pagás
Publikováno v:
Annals of Oncology. 27:850-855
BACKGROUND Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve surviva
Autor:
Anna Easton, David Barros, J.L. Lavandera, Howard Kendrick, R. Leo Brady, A. Cameron, Simon L. Croft, Livia Vivas, Federico Gómez de las Heras
Publikováno v:
Experimental Parasitology. 111:105-114
Plasmodium falciparum lactate dehydrogenase (PfLDH) is essential for ATP generation. Based on structural differences within the active site between P. falciparum and human LDH, we have identified a series of heterocyclic azole-based inhibitors that s
Autor:
Antonio Martı́n-Cuesta, Julia Castro, Federico Gómez de las Heras, Jose M. Coteron, Silvestre Garcı́a-Ochoa, M. Teresa Fraile
Publikováno v:
Tetrahedron Letters. 43:1851-1854
Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromat
Antifungal sordarins. Synthesis and structure–activity relationships of 3′-O-Substituted derivatives
Autor:
Enrique M. Arribas, Ian R. Clemens, Juan C Cuevas, Julia Castro, Jesús Chicharro, Silvestre Garcı́a-Ochoa, Federico Gómez de las Heras, Ma Teresa Fraile, José R Ruiz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:117-120
A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, Candida pseudotropicalis, Candida tropicalis and Cryptococcus neof
Autor:
Sonia Lozano, Domingo Gargallo-Viola, Esperanza Herreros, Federico Gómez de las Heras, Maria Jesus Almela
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:3132-3139
GW 471552, GW 471558, GW 479821, GW 515716, GW 570009, and GW 587270 are members of a new family of sordarin derivatives called azasordarins. The in vitro activities of these compounds were evaluated against clinical isolates of yeasts, including Can
Autor:
Iñigo Angulo, Federico Gómez de las Heras, José F. Garcı́a-Bustos, Domingo Gargallo, M. Angeles Muñoz-Fernández, Manuel Fresno
Publikováno v:
Blood. 95:212-220
During recovery from intensive chemotherapy with cyclophosphamide (CTX), mice suffer a severe but transitory impairment in spleen cell proliferation to T-cell mitogens (Con A or anti-CD3 plus IL-2). Although CTX treatment reduced spleen T-cell cellul
Autor:
Manuel Fresno, M. Ángeles Muñoz-Fernández, Domingo Gargallo, Federico Gómez de las Heras, Iñigo Angulo, Jose F. Garcia-Bustos
Publikováno v:
Blood. 95:212-220
During recovery from intensive chemotherapy with cyclophosphamide (CTX), mice suffer a severe but transitory impairment in spleen cell proliferation to T-cell mitogens (Con A or anti-CD3 plus IL-2). Although CTX treatment reduced spleen T-cell cellul
Autor:
Michael S. Marriott, Federico Gómez de las Heras, Juan Manuel Domínguez, Oonagh S. Kinsman, Valerie A. Kelly, Julio Martin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:2274-2278
GR135402, a sordarin derivative, was isolated in an antifungal screening program. GR135402, sordarin, and derivatives of both compounds were evaluated for their ability to inhibit cell-free translational systems from five different pathogenic fungi (
Autor:
Federico Gómez de las Heras, Antonio Martı́n-Cuesta, Julia Castro, Silvestre Garcı́a-Ochoa, M. Teresa Fraile, Jose M. Coteron
Publikováno v:
ChemInform. 33
Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromat