Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases

Autor: Andres Di Paolo, Joaquin Garat, Guillermo Eastman, Joaquina Farias, Federico Dajas-Bailador, Pablo Smircich, José Roberto Sotelo-Silveira

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Functional genomics studies through transcriptomics, translatomics and proteomics have become increasingly important tools to understand the molecular basis of biological systems in the last decade. In most cases, when these approaches are applied to

Externí odkaz: https://doaj.org/article/25620b23d6e24d2aba50419f168d1fd7

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

Autor: Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman

Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)

Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the ide

Externí odkaz: https://doaj.org/article/b3991ff6c7554f1da5eaf0b9425b3a69

Biological Significance of microRNA Biomarkers in ALS—Innocent Bystanders or Disease Culprits?

Autor: Sophie Foggin, Raquel Mesquita-Ribeiro, Federico Dajas-Bailador, Rob Layfield

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

MicroRNAs (miRNAs) represent potential biomarkers for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). However, whether expression changes of individual miRNAs are simply an indication of cellular dysfunction and degeneratio

Externí odkaz: https://doaj.org/article/8a6c256a600c47109e357560bddcefa8

Vinculin is required for neuronal mechanosensing but not for axon outgrowth

Autor: Ashwaq Albaraky, Karin A. Jansen, Cristina Melero, Paul Atherton, Kristian Franze, Federico Dajas-Bailador, Andrea Dimitracopoulos, Christoph Ballestrem, Adam J Reid, De Yao Wang

Publikováno v: Wang, D, Melero, C, Albaraky, A, Atherton, P, Jansen, K A, Dimitracopoulos, A, Dajas-bailador, F, Reid, A, Franze, K & Ballestrem, C 2021, ' Vinculin is required for neuronal mechanosensing but not for axon outgrowth ', Experimental Cell Research . https://doi.org/10.1016/j.yexcr.2021.112805

Integrin receptors are transmembrane proteins that bind to the extracellular matrix (ECM). In most animal cell types integrins cluster together with adaptor proteins at focal adhesions that sense and respond to external mechanical signals. In the cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116bd4f815801e0926646f95e089525e
https://doi.org/10.1016/j.yexcr.2021.112805

Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae)

Autor: David Gonzalez, Marcela Martínez-Busi, Diego Carvalho, Florencia Arredondo, Juan Andrés Abin-Carriquiry, Mauricio A. Vega-Teijido, Federico Dajas, Felicia Rivera, Carolina Echeverry, Alejandra Rodríguez-Haralambides

Publikováno v: Bioorganic & Medicinal Chemistry. 27:2579-2591

Achyrocline satureioides (Lam) D.C (Compositae) is a native medicinal plant of South America traditionally utilized for its anti-inflammatory, sedative and anti-atherosclerotic properties among others. Neuroprotective effects have been reported in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90ab5297861242ef3a7728477216ad7
https://doi.org/10.1016/j.bmc.2019.03.047